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Known interactions

Adapin, Aldomet, Aldomet Suspension, American Ginseng, Amitriptyline, Amitriptyline Injection, Amoxapine, Anchi, Asendin, Asian Ginseng, Aventyl, Aventyl Oral Solution, Canadian Ginseng, Chinese Ginseng, Desipramine, Doxepin, Doxepin Oral Solution, Doxepin Topical, Elavil, Elavil Injection, Endep, Ephedra, Ephedra sinica, Epitonin, Ergometrine, Ergonovine, Ergonovine Injection, Ergotrate, Ergotrate Injection, Eskalith, Eskalith CR, Etrafon, Five Fingers, Furazolidone, Furazolindone Oral Suspension, Furoxone, Furoxone Oral Suspension, Ginseng, American, Ginseng, Panax, Guigai, Herbal Ecstasy, Imipramine, Imipramine HCl, Imipramine Pamoate, Japanese Ginseng, Korean Ginseng, Lithane, Lithium, Lithium Oral Syrup, Lithium, Extended-Release, Lithobid, Lithonate, Lithotabs, Ma Huang, Mahuang, Methergine, Methergine Injection, Methyldopa, Methyldopa Injection, Methyldopa Oral Suspension, Methylergometrine, Methylergonovine, Methylergonovine Injection, Muzei, Nardil, Ninjin, Norpramin, North American Ginseng, Nortriptyline, Nortriptyline Oral Solution, Oriental Ginseng, Oxytocin, Oxytocin Injection, Pamelor, Panax Ginseng, Panax quinquefolius, Panax schinseng, Parnate, Perphenazine and Amitriptyline, Phenelzine, Pitocin, Popptillo, Protriptyline, Red Berry, Red Ginseng, Ren Shen, Reserpine, Seng, Sinequan, Sinequan Oral Solution, Surmontil, Syntocinon, Tofranil, Tofranil PM, Tranylcypromine, Triavil, Trimipramine, Vanatrip, Vanatrip Injection, Vivactil, Zonalon Cream.

On-line 4-Way Fast Acting

Brand Name(s): 4-Way Fast Acting, Afrin Children's Pump Mist, Ah-chew D, Little Colds, Little Noses Gentle Formula, Infants & Children, Neo-Synephrine 4-Hour, Rhinall, Vicks Sinex Ultra Fine Mist

Generic Name Phenylephrine Nasal

What are phenylephrine nose drops, spray, or jelly?

PHENYLEPHRINE (Neo-Synephrine®) acts as a decongestant to relieve nasal congestion (stuffiness) in patients with colds and sinus problems. Generic phenylephrine nose drops are available.

What should my health care professional know before I use phenylephrine?

They need to know if you have any of the following conditions:

  • head injury or disease
  • heart disease
  • glaucoma
  • high blood pressure
  • over active thyroid
  • an unusual or allergic reaction to phenylephrine, sulfites, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Phenylephrine nose drops, spray or jelly are only for use in the nose. Do not take by mouth. Follow the directions on the prescription label. Blow your nose gently. If you are using nasal drops, lie down on a bed and hang your head over the side or tilt your head back while sitting or standing. Place the prescribed number of drops into each nostril. Keep your head tilted back for several minutes. Rinse the dropper with hot water and dry. If you are using a nasal spray, keep your head in the upright position and spray into each nostril. Do not use the container for more than one person. If you are using the nasal jelly, place a little jelly in each nostril, and sniff well back into the nose. Blow your nose well about 3 to 5 minutes after using phenylephrine. Do not use more often than directed.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What drug(s) may interact with phenylephrine?

  • atropine
  • bromocriptine
  • linezolid
  • maprotiline
  • medicines for mental depression
  • medicines for migraine
  • medicine for high blood pressure
  • oxytocin
  • vasopressin
  • water pills

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check before starting or stopping any of your medicines.

What side effects may I notice from using phenylephrine?

Side effects that you should report to your prescriber or health care professional as soon as possible:

  • dizziness, or fainting spells
  • difficulty breathing
  • irregular heartbeat, palpitations, or chest pain
  • swelling of the inside of the nose

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • burning, stinging, dryness, or local irritation inside your nose
  • headache
  • nervousness
  • sneezing or runny nose

What should I watch for while taking phenylephrine?

Check with your prescriber or health care professional if your condition has not improved within 1 week, or if it has got worse. Using phenylephrine for more than 3 to 5 days can make your runny or stuffy nose worse and increase your risk of developing side effects.

If you get a slight stinging sensation in the nose after using phenylephrine it is of no cause for concern. The effect should go away after a few applications.

If you get any of the possible serious side effects, check with your prescriber or health care professional. You may be using too much phenylephrine.

Where can I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 °C (59 and 86 °F); do not freeze. Protect from light. Do not use if solution is brown or contains a precipitate. Do not use the jelly if it is brown. Throw away any unused medicine after the expiration date.


(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

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