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Description of Cardizem Injection

Brand Name(s): Cardizem Injection

Generic Name Diltiazem Injection

What is diltiazem injection?

DILTIAZEM (Cardizem®) is a calcium-channel blocker. It affects the amount of calcium found in your heart and muscle cells. This results in relaxation of blood vessels, which can reduce the amount of work the heart has to do. Diltiazem injection steadies and slows a fast, uneven heart rate. Generic diltiazem injections are available.

What should my health care professional know before I receive diltiazem?

They need to know if you have any of these conditions:

  • heart problems, low blood pressure, irregular heartbeat
  • liver disease
  • previous heart attack
  • an unusual or allergic reaction to diltiazem, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Diltiazem is for injection or infusion into a vein. It is given in a hopital or clinic setting by a health-care professional.

What if I miss a dose?

This does not apply.

What drug(s) may interact with diltiazem?

Do not take Diltiazem injection with any of the following:

  • astemizole
  • cisapride
  • pimozide
  • terfenadine

Diltiazem may also interact with the following medications:

  • alfuzosin
  • alosetron
  • antiinflammatory drugs (NSAIDs, such as ibuprofen)
  • aspirin
  • barbiturates such as phenobarbital
  • bosentan
  • certain antibiotics (clarithromycin, erythromycin, telithromycin, troleandomycin)
  • certain medicines used to treat cancer
  • certain medicines to treat migraine (ergotamine, dihydroergotamine, methysergide)
  • cilostazol
  • cimetidine
  • clonidine
  • cyclosporine
  • doxercalciferol
  • fentanyl
  • galantamine
  • herbal or dietary supplements such as ginger, ginkgo biloba, ginseng, hawthorn, ma huang (ephedra), melatonin, St. John's wort, went yeast
  • lithium
  • local anesthetics or general anesthetics
  • medicines for anxiety or difficulty sleeping (examples: alprazolam, buspirone, midazolam, triazolam)
  • medicines for depression or mental problems (imipramine, fluoxetine, fluvoxamine, nefazodone, ziprasidone)
  • medicines for fungal infections (fluconazole, itraconazole, ketoconazole, voriconazole)
  • medicines for heart-rhythm problems (amiodarone, digoxin, disopyramide, dofetilide, encainide, flecainide, moricizine, procainamide, quinidine)
  • medicines for high cholesterol (atorvastatin, cerivastatin, colesevelam, lovastatin, simvastatin)
  • medicines for high blood pressure or heart problems
  • medicines for HIV infection or AIDS
  • medicines for prostate problems
  • medicines for seizures (carbamazepine, clonazepam, ethosuximide, phenobarbital, phenytoin, primidone, zonisamide)
  • methadone
  • paricalcitol
  • rifampin, rifabutin, or rifapentine
  • sildenafil
  • sirolimus
  • tacrolimus
  • theophylline or aminophylline
  • water pills (diuretics)
  • yohimbine
  • zafirlukast
  • zileuton

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from receiving diltiazem?

These effects were recorded for diltiazem injection. Other side effects may occur.

Side effects that you should report to your prescriber or health care professional as soon as possible:

  • burning, prickling or tingling
  • difficulty breathing
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • skin rash, itching
  • slow heartbeat, irregular heartbeat, chest pain
  • swelling of the feet and ankles
  • unusual weakness or tiredness

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • constipation
  • dry mouth
  • drowsiness or dizziness
  • facial flushing
  • headache
  • nausea, vomiting
  • sexual dysfunction

What should I watch for while taking diltiazem?

Check your blood pressure and pulse rate regularly; this is important while you are taking diltiazem. Ask your prescriber or health care professional what your blood pressure and pulse rate should be and when you should contact him or her.

You may feel dizzy or lightheaded. Do not drive, use machinery, or do anything that needs mental alertness until you know how diltiazem affects you. To reduce the risk of dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Avoid alcoholic drinks; they can make you more dizzy or increase flushing and rapid heartbeats.

If you are going to have surgery, tell your prescriber or health care professional that you are taking diltiazem.

Do not suddenly stop taking diltiazem. Ask your prescriber or health care professional how to gradually reduce the dose.

Where can I keep my medicine?

Keep out of the reach of children.

Store in a refrigerator between 2 and 8 °C (36 and 46 °F); do not freeze. This injection may be kept at room temperature, below 25 °C (77 °F), for up to one month. Throw away after one month at room temperature.


(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

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