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Known interactions

American Ginseng, Ammonium Chloride Injection, Ammonium Choride Oral, Anchi, Asian Ginseng, Baking Soda, Bell-Ans, Bicitra, Canadian Ginseng, Celexa, Celexa Solution, Chinese Ginseng, Chlorpromazine, Chlorpromazine Concentrate or Syrup, Chlorpromazine Extended-Release Capsules, Chlorpromazine Injection, Chlorpromazine Intensol Concentrate, Chlorpromazine Suppositories, Citalopram, Citalopram Oral Solution, Citalopram orally-disintegrating tablets, Citric Acid and Potassium Citrate Oral Solution, Citric Acid and Sodium Citrates, Citrocarbonate, Compazine, Compazine Injection, Compazine Rectal Suppositories, Compazine Spansules, Compazine Syrup, Cytra-2, citalopram orally-disintegrating tablets, Effexor, Etrafon, Five Fingers, Fluoxetine and Olanzapine, Fluoxetine capsules (Sarafem), Fluoxetine Oral Solution, Fluoxetine tablets or capsules, Fluphenazine, Fluphenazine Injection, Fluphenazine Oral Concentrate or Elixir, Fluvoxamine, Furazolidone, Furazolindone Oral Suspension, Furoxone, Furoxone Oral Suspension, fluoxetine delayed-release capsules, Ginseng, American, Ginseng, Panax, Guigai, Isocarboxazid, Japanese Ginseng, Korean Ginseng, Luvox, Marplan, Mellaril, Mellaril Suspension, Mellaril-S, Mesoridazine Injection, Mesoridazine Oral, Mesoridazine Oral Concentrate, Nardil, Neut, Ninjin, North American Ginseng, Oracit, Oriental Ginseng, Panax Ginseng, Panax quinquefolius, Panax schinseng, Parnate, Paroxetine, Paroxetine Oral Suspension, Paxil, Paxil CR, Paxil Suspension, Permitil, Permitil Oral Concentrate, Perphenazine and Amitriptyline, Perphenazine Injection, Perphenazine Oral, Perphenazine Oral Concentrate, Phenelzine, Polycitra-K, Potassium Citrate, Prochlorperazine, Prochlorperazine ER, Prochlorperazine Injection, Prochlorperazine Oral Syrup, Prochlorperazine Rectal Suppositories, Prolixin, Prolixin Decanoate, Prolixin Elixir, Prolixin Enanthate, Prolixin Injection, Prolixin Oral Concentrate, Prozac, Prozac Oral Solution, Prozac Weekly, Red Berry, Red Ginseng, Ren Shen, Sarafem, Seng, Serentil, Serentil Injection, Serentil Oral Concetrate, Sertraline, Sertraline Oral Solution, Soda Mint, Sodium Bicarbonate, Sodium Bicarbonate Injection, Sodium Bicarbonate Powder, Sodium Lactate, Sonazine Concentrate, Sonazine Syrup, Stelazine, Stelazine Injection, Symbyax, Thioridazine Suspension, Thioridazine Tablets, Thor-Prom, Thorazine, Thorazine Concentrate, Thorazine Injection, Thorazine Spansule, Thorazine Suppositories, Thorazine Syrup, Tranylcypromine, Triavil, Trifluoperazine Injection, Trifluoperazine Oral Concentrate, Trifluoperazine Oral Tablets, Trilafon, Trilafon Concentrate, Trilafon Injection, Urocit-K, Venlafaxine, Zoloft, Zoloft Oral Solution.

Info about Adderall

Brand Name(s): Adderall

Generic Name Amphetamine and Dextroamphetamine

What are amphetamine; dextroamphetamine tablets?

AMPHETAMINE; DEXTROAMPHETAMINE (Adderall®) is a stimulant. This medicine can improve attention span, concentration, and emotional control, and reduce restless or overactive behavior. This medicine treats attention-deficit hyperactivity disorder (ADHD) and can also help a condition called narcolepsy, an illness that makes it difficult to stay awake during normal daytime hours. This medication is rarely used for weight loss. Federal law prohibits giving this medicine to any person other than the person for whom it was prescribed. Do not share this medicine with anyone else. Generic amphetamine-dextroamphetamine tablets are available.

NOTE: Certain drug products (e.g., Adderall® XR, see separate patient education sheet) of this drug have been discontinued in Canada due to concerns surrounding reports of sudden unexplained death (SUD) in children. In the U.S., patients should not stop taking these products unless told to do so by their health care provider; patients, parents, or caregivers should contact the health care provider with any questions. SUD has been associated with amphetamine abuse and reported in children with underlying heart defects taking amphetamines. In addition, a very small number of cases of SUD have been reported in children without heart defects taking amphetamines. The U.S. FDA continues to allow marketing of these products, and continues to study the data regarding these possible serious events.

What should my health care professional know before I take amphetamine-dextroamphetamine?

They need to know if you have any of these conditions:

  • regularly drink alcohol-containing beverages
  • diabetes or high blood sugar
  • glaucoma
  • hardening or blockages of the arteries or heart blood vessels
  • heart disease or a heart defect
  • high blood pressure
  • history of drug abuse
  • over-active thyroid gland
  • psychotic illness, depressed mood, or suicidal thoughts
  • recent weight loss
  • seizure disorder
  • Tourette's syndrome
  • an unusual or allergic reaction to dextroamphetamine, other amphetamines, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I take this medicine?

Take amphetamine-dextroamphetamine tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water. Do not take your medicine more often than directed. Do not stop taking except on your prescriber's advice.

Remember: The prescription for amphetamine-dextroamphetamine is only for the person for whom it was prescribed. Never share or give your prescription to anyone else.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Amphetamine-dextroamphetamine has been prescribed for children 3 years of age and older for the treatment of attention-deficit disorder. This medicine should not be used in children under the age of 12 years for weight loss.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What drug(s) may interact with amphetamine; dextroamphetamine?

Do not take Amphetamine; Dextroamphetamine with any of the following medications:

  • medicines called MAO inhibitors used to treat depression - examples: phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®). Never take Amphetamine; Dextroamphetamine if you are taking a MAO inhibitor, or if you have stopped taking a MAO inhibitor in the last 14 days.

Amphetamine; Dextroamphetamine may also interact with the following medications:

  • acetazolamide
  • alcohol containing beverages
  • bupropion
  • caffeine
  • furazolidone
  • guarana
  • insulin and other medicines for diabetes
  • levodopa
  • linezolid
  • lithium
  • medicines for colds, sinus, and breathing difficulties
  • medicines for high blood pressure and heart medicines
  • other medicines for mental depression or anxiety
  • medicines for mental problems and psychotic disturbances
  • some medicines for migraines (propranolol)
  • medicines to decrease appetite or cause weight loss
  • meperidine
  • melatonin
  • other stimulant medications (examples: dexmethylphenidate, methylphenidate, modafinil)
  • pimozide
  • propoxyphene
  • seizure (convulsion) or epilepsy medicine
  • selegiline
  • sodium bicarbonate
  • thyroid hormones

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from taking amphetamine-dextroamphetamine?

Side effects that you should report to your prescriber or health care professional as soon as possible:

  • anxiety, or severe nervousness
  • changes in mood or behavior, including seeing or hearing things that are not really there or over-focused, staring-type behavior
  • chest pain, fast or irregular heartbeat (palpitations)
  • fever, or hot, dry skin
  • increased blood pressure
  • muscle twitching
  • skin rash and itching (hives)
  • uncontrollable head, mouth, neck, arm, or leg movements

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

Less Common or Rare:

  • a sense of well being
  • blurred vision
  • changes in sexual ability or desire (adults and teenagers)
  • constipation or diarrhea
  • dizziness or lightheadedness
  • increased sweating
  • nausea, vomiting
  • stomach cramps

More Common, especially in the first few weeks of treatment:

  • decreased appetite or loss of appetite
  • headache
  • mild stomach upset
  • nervousness, restlessness, or difficulty sleeping
  • weight loss

What should I watch for while taking amphetamine-dextroamphetamine?

Visit your prescriber or health care professional for regular checks on your progress. This prescription requires that you follow special procedures with your prescriber and pharmacy; you will need to have a new written prescription from your prescriber every time you need a refill.

This medicine may affect your concentration, or hide signs of tiredness. Until you know how this medicine affects you, do not drive, ride a bicycle, use machinery, or do anything that needs mental alertness.

Tell your prescriber or health care professional if this medicine loses its effects, or if you feel you need to take more than the prescribed amount. Do not change the dosage without advice from your prescriber or health care professional. Do not suddenly stop your medication. You must gradually reduce the dose or you may feel withdrawal effects. Ask your prescriber or health care professional for advice.

Decreased appetite is a common side effect when starting this medicine. Eating small, frequent meals or snacks can help. Talk to your prescriber if you continue to have poor eating habits. Height and weight growth of a child taking this medication will be monitored closely.

If you are going to have surgery or will need an x-ray procedure that uses contrast agents, tell your prescriber or health care professional that you are taking this medicine.

Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open.

Store at room temperature between 15 and 30 °C (59 and 86 °F). Keep container tightly closed. Throw away any unused medicine after the expiration date.


(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

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