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What we now about A-hydroCort

Brand Name(s): A-hydroCort, Hydrocortone Acetate, Hydrocortone Phosphate, Solu-Cortef

Generic Name Hydrocortisone Injection

What is hydrocortisone injection?

HYDROCORTISONE (Hydrocortone Acetate®, Hydrocortone Phosphate®, A-HydroCort®, Solu-Cortef®) is a corticosteroid. It helps to reduce swelling, redness, itching, and allergic reactions. Hydrocortisone is similar to natural steroid hormone produced by the adrenal gland. Hydrocortisone treats severe allergies, skin problems, asthma, arthritis, or many other conditions. Generic hydrocortisone injections are available in a variety of forms.

What should my health care professional know before I receive hydrocortisone?

They need to know if you have any of these conditions:

  • blood clotting disorder
  • Cushing's syndrome
  • diabetes
  • high blood pressure
  • infection, including chicken-pox, herpes, measles, or tuberculosis
  • liver disease
  • myasthenia gravis
  • osteoporosis
  • previous heart attack
  • psychosis
  • seizures (convulsions)
  • stomach or intestinal disease
  • under-active thyroid
  • an unusual or allergic reaction to hydrocortisone, corticosteroids, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Hydrocortisone injections come in a number of different forms. Depending on the formulation they are for injection into a muscle, into a vein, under the skin, or into joints, soft tissue, or lesions. The injections are given by a health-care professional.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

This does not apply. Repeat injections are given as decided by your prescriber or health care professional.

What drug(s) may interact with hydrocortisone?

  • antiinflammatory drugs (NSAIDs, such as ibuprofen)
  • aspirin
  • barbiturate medicines for inducing sleep or treating seizures (convulsions)
  • bosentan
  • carbamazepine
  • female hormones, including contraceptive or birth control pills
  • heart medicine
  • medicines for diabetes
  • medicines that improve muscle strength or tone for conditions like myasthenia gravis
  • phenytoin
  • rifampin
  • toxoids and vaccines
  • water pills

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from receiving hydrocortisone?

Side effects that you should report to your prescriber or health care professional as soon as possible:

  • bloody or black, tarry stools
  • confusion, excitement, restlessness, a false sense of well-being
  • eye pain, decreased or blurred vision, or bulging eyes
  • fever, sore throat, sneezing, cough, or other signs of infection
  • frequent passing of urine
  • hallucinations (seeing and hearing things that are not really there)
  • increased thirst
  • irregular heartbeat
  • menstrual problems
  • mental depression, mood swings, mistaken feelings of self-importance, mistaken feelings of being mistreated
  • muscle cramps or muscle weakness
  • nausea, vomiting
  • pain in hips, back, ribs, arms, shoulders, or legs
  • pain, redness, swelling, or inflammation at the injection site
  • rounding out of face
  • skin problems, acne
  • stomach pain
  • swelling of feet or lower legs
  • unusual bruising or red pinpoint spots on the skin
  • unusual tiredness or weakness
  • weight gain or weight loss
  • wounds that will not heal

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • diarrhea or constipation
  • change in taste
  • headache
  • increased appetite or loss of appetite
  • increased sweating
  • nervousness, restlessness, or difficulty sleeping
  • unusual increased growth of hair on the face or body
  • upset stomach

What should I watch for while taking hydrocortisone?

Visit your prescriber or health care professional for regular checks on your progress. If you are receiving corticosteroids for a long time, carry an identification card with your name, the type and dose of corticosteroid, and your prescriber's name and address. Do not suddenly stop using hydrocortisone. You may need to gradually reduce the dose, so that your body can adjust. Follow the advice of your prescriber or health care professional.

If you receive corticosteroids for a long time, avoid contact with people who have an infection. You may be at an increased risk from infection while using hydrocortisone. Tell your prescriber or health care professional if you are exposed to anyone with measles or chickenpox, or if you develop sores or blisters that do not heal properly.

People who are taking certain dosages of hydrocortisone may need to avoid immunization with certain vaccines or may need to have changes in their vaccination schedules to ensure adequate protection from certain diseases. Make sure to tell your prescriber or health care professional that you are taking hydrocortisone before receiving any vaccine.

If you have an injection of hydrocortisone directly into a joint, try not to put too much stress on that joint, even if it feels better.

If you are diabetic, hydrocortisone can affect your blood sugar. Check with your prescriber or health care professional if you need help adjusting the dose of your diabetic medicine.

If you receive hydrocortisone every day, you may need to watch your diet. Your body can also lose potassium while you take this medicine. Ask your prescriber or health care professional about your diet, especially about your salt intake.

If you are going to have surgery tell your prescriber or health care professional that you are receiving hydrocortisone, or have used it within the last 12 months.

Alcohol can increase the risk of getting serious side effects while you are receiving hydrocortisone. Avoid alcoholic drinks.

Elderly patients have an increased risk of side effects from hydrocortisone.

Hydrocortisone can interfere with certain lab tests and can cause false skin test results.

Where can I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 °C (59 and 86 °F); do not freeze. Throw away any unused medicine after the expiration date.


(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

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