Known interactions

Absinthe, Activated Charcoal, Actonel with calcium, Acyclovir, Acyclovir Cream or Ointment, Acyclovir Oral Suspension, Acyclovir Sodium Injection, Adapin, Ajenjo, Alamag, Alamag Suspension, Alenic Alka, Almora, Alprazolam Intensol, Alprazolam Oral Solution, Alprazolam tablets, AlternaGEL, AlternaGEL Liquid, Alu-Cap, Alu-Tab, Aludrox, Aluminum and Magnesium Hydroxide, Aluminum and Magnesium Hydroxide Oral Suspension, Aluminum Hydroxide, Aluminum Hydroxide and Magnesium Trisilicate, Aluminum Hydroxide Oral Liquid, Aluminum Hydroxide, Magnesium Carbonate Chewables, Aluminum Hydroxide, Magnesium Carbonate Oral Suspension, Aluminum Hydroxide, Magnesium Hydroxide, and Simethicone, Aluminum Hydroxide, Magnesium Hydroxide, and Simethicone oral suspension, Amigesic, Amitone, Amitriptyline, Amitriptyline Injection, Amoxapine, Amphojel, Amphojel Suspension, Anafranil, Antispasmodic Elixer, Argesic-SA, Armoise, Artemisia absinthium, Artha-G, Arthropan, Asendin, Aspirin and Carisoprodol, Aspirin, Caffeine and Dihydrocodeine, Ativan, Ativan Injection, Atretol, Atropine, Hyoscyamine, Phenobarbital, and Scopolamine Elixir, Atropine, Hyoscyamine, Phenobarbital, and Scopolamine Oral, Aventyl, Aventyl Oral Solution, AZT Capsule, AZT Injection, AZT Oral Syrup, AZT tablets, Azidothymidine Capsule, Azidothymidine Injection, Bellacane SR, Belladonna Alkaloids, Ergotamine, and Phenobarbital Tablets, Bellaspas, Bellergal-S, Bismatrol, Bismatrol Extra Strength, Bismatrol Oral Liquid, Bismuth Subsalicylate, Bismuth Subsalicylate Oral Liquid, Bismuth Subsalicylate, Metronidazole, and Tetracycline Combination, Buffered Aspirin and Pravastatin, Caffeine, Aspirin and Dihydrocodeine, Calcium Carbonate Tablets, Caltrate 600, Carbamazepine, Carbamazepine ER, Carbamazepine Suspension, Carbatrol, Carisoprodol Compound, Celontin, CharcoAid, Charcoal, Charcoal capsules, Charcoal Plus, Charcoal powder or oral suspension, CharcoCaps, Children's Kaopectate, Chlordiazepoxide, Chlordiazepoxide and Clidinium Bromide, Chlordiazepoxide Injection, Chlorpromazine, Chlorpromazine Concentrate or Syrup, Chlorpromazine Extended-Release Capsules, Chlorpromazine Injection, Chlorpromazine Intensol Concentrate, Chlorpromazine Suppositories, Cholestyramine Powder for Suspension, Choline Magnesium Trisalicylate, Choline Salicylate and Magnesium Salicylate Solution, Choline Salicylate oral solution, Cimetidine, Cimetidine Injection, Cimetidine Liquid, Clomipramine, Clonazepam, Clonazepam Orally Disintegrating Tablets, Clorazepate, Clozapine, Clozapine Orally-Disentegrating Tablets, Clozaril, Compound S, Compound S Capsule, Compound S Oral Syrup, Coumadin, Coumadin Injection, Dalmane, Desipramine, Di-Gel, Dialume, Diastat, Diazepam, Diazepam Injection, Diazepam Intensol, Diazepam Oral Solution, Diazepam Rectal Gel, Dicarbosil, Dihydrocodeine, Aspirin and Caffeine, Dilantin, Dilantin Infatab, Dilantin Injection, Dilantin Kapseals, Dilantin-125, Diotame Oral Liquid, Disalcid, Donnatal, Donnatal Elixir, Doral, Doxepin, Doxepin Oral Solution, Doxepin Topical, E.E.S, Elavil, Elavil Injection, Endep, Ephedra, Ephedra sinica, Epitol, Epitonin, Equetro, Equilet, ERYC, Ertapenem, EryTab, Erythrocin, Erythromycin ER, Erythromycin Tablets, Capsules, and Extended-Release, Ethosuximide Capsules, Ethosuximide Oral Solution, Ethotoin, Etrafon, Evening Primrose, Extra Strength Kaopectate, Fazoclo, Felbamate, Felbamate Oral Suspension, Felbatol, Felbatol Oral Suspension, Fever Plant, Fluoxetine and Olanzapine, Fluoxetine capsules (Sarafem), Fluoxetine Oral Solution, Fluoxetine tablets or capsules, Flurazepam, Folergot-DF, fluoxetine delayed-release capsules, Gaviscon, Gaviscon Chewable, Gaviscon Chewable Tablets, Ginkgo, Ginkgo Biloba, Green Ginger, Halcion, Helidac, Herbal Ecstasy, Hyosophen Elixer, Imipenem and Cilastatin Sodium Injection, Imipramine, Imipramine HCl, Imipramine Pamoate, INH, INH Oral Syrup, Invanz, Iosopan, Isoniazid, Isoniazid Injection, Isoniazid Oral Syrup, Jantoven, Japanese Silver Apricot, Kaopectate, Kew Tree, Klonopin, Klonopin Wafer, Lamictal, Lamotrigine, Librax, Libritabs, Librium, Librium Injection, Lorazepam, Lorazepam Injection, Lorazepam Intensol, Lorazepam Oral Solution, Luminal Sodium, Ma Huang, Maalox, Maalox Suspension, Madderwort, Mag-Ox, Magaldrate, Magan, Magnalox, Magnalox Suspension, Magnesium Gluconate, Magnesium Hydroxide, Magnesium Hydroxide Chewable Tablets, Magnesium Oxide, Magnesium Salicylate, Magnesium Sulfate Injection, Magnox Suspension, Magonate, Magtrate, Mahuang, Maidenhair Tree, Mallamint, Maox, Marthritic, Meropenem Injection, Merrem IV, Methsuximide Oral, Midazolam Injection, Midazolam Syrup, Milk of Magnesia, Milk of Magnesia-Concentrated, Mintox Suspension, Mobidin, Momentum, Monogesic, Muzei, Mylanta, Mylanta Oral Suspension, Mylanta tablets, Mysoline, Mysoline Suspension, Niravam, Norpramin, Nortriptyline, Nortriptyline Oral Solution, Nydrazid, Nydrazid Injection, OEP, Oenothera species, Pamelor, PCE, Peganone, Pepto Bismal Oral Liquid, Pepto-Bismol, Pepto-Bismol Maximum Strength, Perphenazine and Amitriptyline, Phenerbel-S, Phenobarbital, Phenobarbital Elixir, Phenobarbital Injection, Phenytek, Phenytoin, Phenytoin Chewable, Phenytoin Injection, Phenytoin Oral Suspension, Phillips Milk of Magnesia, Phillips' Chewable, Pink Bismuth, Popptillo, Pravigard PAC, Prevalite, Primaxin, Primidone, Primidone Oral Suspension, Protriptyline, Prozac, Prozac Oral Solution, Prozac Weekly, Quazapam, Questran, Questran Light, Retrovir Capsule, Retrovir Injection, Retrovir Oral Syrup, Retrovir tablets, Riopan, Risedronate with calcium carbonate, Risperdal, Risperdal Consta, Risperdal Oral Solution, Risperidone, Risperidone Injection, Risperidone Oral Solution, Rulox, Salflex, Salgesic, Salsalate, Salsitab, Sarafem, Sinequan, Sinequan Oral Solution, Sodium Thiosulfate and Salicylic Acid Lotion, Sodol Compound, Solfoton, Soma Compound, Sonazine Concentrate, Sonazine Syrup, Spastrin, Sun Drop, Surmontil, Symbyax, Synalgos-DC, Tagamet, Tagamet HB, Tagamet Injection, Tagamet Liquid, Tegretol, Tegretol Suspension, Tegretol XR, Thor-Prom, Thorazine, Thorazine Concentrate, Thorazine Injection, Thorazine Spansule, Thorazine Suppositories, Thorazine Syrup, Titralac, Tofranil, Tofranil PM, Topamax, Topiramate, Tranxene, Tranxene T, Tranxene-SD, Triavil, Triazolam, Trilisate Solution, Trimipramine, Tums, Uro-Mag, Valium, Valium Injection, Vanatrip, Vanatrip Injection, Versed, Versed Syrup, Versiclear, Vivactil, Warfarin, Warfarin injection, Wermut, Wormwood, Xanax, Yinhsing, Zarontin, Zarontin Oral Solution, ZDV Capsule, ZDV Oral Syrup, ZDV tablets, Zidovudine Capsule, Zidovudine Injection, Zidovudine Oral Syrup, Zidovudine tablets, Zonalon Cream, Zovirax, Zovirax Cream or Ointment, Zovirax Injection, Zovirax Oral Suspension.

Introduction into Depakene

Brand Name(s): Depakene

Generic Name Valproic Acid Capsules

What are valproic acid capsules?

VALPROIC ACID capsules (Depakene®) can help with seizure (convulsion) control in certain types of epilepsy. This drug also is used for other conditions, such as treatment of bipolar disorder, mania, migraines, and behavioral problems associated with Alzheimer's disease or dementia. Generic valproic acid capsules are available.

What should my health care professional know before I take valproic acid?

They need to know if you have any of these conditions:

  • blood disease
  • brain damage or disease
  • kidney disease
  • liver disease
  • low blood proteins
  • urea cycle disorder (UCD)
  • an unusual or allergic reaction to valproic acid, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I take this medicine?

Take valproic acid capsules by mouth. Follow the directions on the prescription label. Swallow the capsules whole with a drink of water. If valproic acid upsets your stomach, take it with food or milk; do not take with carbonated drinks. Take your doses at regular intervals. Do not take your medicine more often than directed.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you take only one dose each day, take the missed dose as soon as you remember. If you do not remember until the next day, skip the missed dose and go on with your regular schedule. Do not take double or extra doses. If you take more than one dose a day and miss a dose, take it if you remember within 6 hours. Space the other doses for that day at regular intervals, do not take two doses at once.

What drug(s) may interact with valproic acid?

  • agents that dissolve blood clots
  • alcohol
  • antacids
  • antiinflammatory drugs (NSAIDs, such as ibuprofen)
  • aspirin
  • barbiturate medicines for inducing sleep or treating seizures (convulsions)
  • blood thinners
  • isoniazid
  • medicines for mental depression
  • medicines for mental problems and psychotic disturbances
  • other seizure (convulsion) or epilepsy medicines

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your healthcare professional before stopping or starting any medicines while taking valproic acid.

What side effects may I notice from taking valproic acid?

Side effects that you should report to your prescriber or health care professional as soon as possible:

  • agitation, restlessness, irritability, or other changes in mood
  • blurred or double vision or uncontrollable eye movements
  • changes in the frequency or severity of seizures
  • double vision, or involuntary eye movements
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • skin rash or itching
  • stomach pain or cramps
  • trembling of hands or arms
  • unusual bleeding or bruising or pinpoint red spots on the skin
  • unusual swelling of the arms or legs
  • unusual tiredness or weakness
  • yellowing of skin or eyes

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • breast enlargement, unusual production of breast milk
  • changes in menstrual periods
  • clumsiness or unsteadiness
  • diarrhea or constipation
  • difficulty speaking
  • dizziness or drowsiness
  • headache
  • increased sensitivity to sun or ultraviolet light
  • irregular menstrual cycle
  • loss of bladder control
  • loss of hair or unusual growth of hair
  • loss or increase in appetite
  • nausea or vomiting
  • skin rash, itching
  • weight gain or loss

What should I watch for while taking valproic acid?

Visit your prescriber or health care professional for a regular check on your progress.

If you are taking valproic acid to treat epilepsy (seizures), do not stop taking valproic acid suddenly. This increases the risk of seizures. Wear a Medic Alert bracelet or necklace. Carry an identification card with information about your condition, medications, and prescriber or health care professional.

Do not change brands or dosage forms of valproic acid without discussing the change with your prescriber or healthcare professional.

You may get drowsy, dizzy, or have blurred vision. Do not drive, use machinery, or do anything that needs mental alertness until you know how valproic acid affects you. To reduce dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Alcohol can increase drowsiness and dizziness. Avoid alcoholic drinks.

Valproic acid can cause blood problems. This can mean slow healing and a risk of infection. Problems can arise if you need dental work, and in the day to day care of your teeth. Try to avoid damage to your teeth and gums when you brush or floss your teeth.

If you are going to have surgery, tell your prescriber or health care professional that you are taking valproic acid.

Where can I keep my medicine?

Keep out of reach of children in a container that small children cannot open.

Store at room temperature between 15 and 25 °C (59 and 77 °F). Keep container tightly closed. Throw away any unused medicine after the expiration date.

(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

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