Known interactions

Abciximab Injection, Acanthopanax senticosus, Acarbose, Acetohexamide, Achillea, Achillea millefolium, Ackerkraut, Actoplus Met, Actos, African Pepper, Agathosma betulina, Aggrastat, Agrimonia, Agrimonia eupatoria, Agrimony, Agrylin, Airelle, Alant, Alfalfa, Alhova, Allium, Allium sativum, Aloe barbadensis, Aloe species, Aloe vera, Altamisa, Amachazuru, Amaryl, American Cranberry, American Ginseng, Amorphophallus konjac, Anagrelide, Anchi, Angelica polymorpha, Angelica sinensis, Anthemis nobilis, Apidra, Apricot Vine, Arandano, Ardeparin Sodium Injection--No longer available, Armoracia rusticana, Asian Ginseng, Aspirin and Carisoprodol, Aspirin, Caffeine and Dihydrocodeine, Avandamet, Avandia, Awa, Azucacaa, Baikal Scullcap, Baikal Skullcap Root, Bal, Barley, Barley Grass, Barosma betulina, Basket Willow, Bdellium, Bee Bread, Bilberry, Bird Pepper, Bird's Foot, Black ginger, Black Psyllium, Blond Psyllium, Bloodwort, Blowball, Bol, Borage, Borago officinalis, Bramhi, Bridewort, Bucco, Buchu, Buffered Aspirin and Pravastatin, Bugloss, Buku, Burn Plant, Cabbage Palm, Cacari, Caffeine, Aspirin and Dihydrocodeine, Camocamo, Camu-camu, Canadian Ginseng, Canker Wort, Canton ginger, Cape Aloe, Capim Doce, Capsicum, Capsicum annuum, Capsicum frutescens, Carica papaya, Carisoprodol Compound, Centella asiatica, Chamomile, Chili Pepper, Chinese Angelica, Chinese Ginseng, Chinese Sage, Chlorpropamide, Chondroitin, Chondroitin Sulfate, Chroma-Pak injection, Chromic Chloride injection, Chromium, Chromium 3, Chromium Acetate, Chromium Chloride, Chromium chloride injection, Chromium injection, Chromium Picolinate, Chrysanthemum parthenium, Church Steeples, Ci Wu Jia, Cilostazol, Clopidogrel, Co Q 10, Cochin ginger, Cochlearia armoracia, Cocklebur, Coenzyme Q-10, Commiphora molmol, Commiphora myrrha, Common Borage, Common Bugloss, Common ginger, Corona de Cristo, Coumadin, Coumadin Injection, Cow Clover, Crack Willow, Cranberry, Curcuma, Curcuma species, Daidzein, Dalteparin Injection, Damiana, Danaparoid Injection, Dandelion, Danggui, Danshen, Devil's Bush, Devil's Claw, Devil's Leaf, Devil's Tongue, Diabeta, Diabinese, Dihydrocodeine, Aspirin and Caffeine, Diosma, Dipyridamole, Dipyridamole Injection, Dong Quai, Dropwort, Dyeberry, Dymelor, Elecampane, Elephant-foot Yam, Eleuthero, Eleutherococcus senticosus, Elf Dock, Elfwort, Enebro, Enoxaparin Injection, Eptifibatide, Erva Doce, Eucalyptus, European Blueberry, Evening Primrose, Fan Palm, Featherfew, Fenugreek, Feuille de Luzerna, Fever Plant, Feverfew, Filipendula ulmaria, Five Fingers, Flaxseed, Flaxseed oil, Flea Seed, Flirtwort, Fortamet, Fragmin, Funffing, Gan Cao, Garden ginger, Garlic, Ge Gen, Genevrier, Genuine chamomile, German Chamomile, German Mustard, Ginepro, Gingembre, Ginger, Ginkgo, Ginkgo Biloba, Ginseng, American, Ginseng, Panax, Glimepiride, Glipizide, Glipizide and Metformin, Glipizide Extended-Release, Glucomannan, Glucophage, Glucophage XR, Glucotrol, Glucotrol XL, Glucovance, Glyburide, Glyburide and Metformin, Glycine max, Glycine soja, Glycyrrhiza glabra, Glynase, Glyset, Goat's Pod, Gotu Kola, Graine de lin, Granadilla, Grape Seed, Grape Seed Extract, Grapple Plant, Great Raifort, Greek Clover, Greek Hay, Green Arrow, Guavaberry, Guggal Resin, Guigai, Gum Myrrh, Gurmar, Gymnema sylvestre, Gynostemma, Gynostemma pentaphyllum, Harpagophytum procumbens, Heerabol, Heparin Injection, Herba de la pastora, Herbe de Saint-Guillaume, Hordeum vulgare, Horse Chestnut, Horse Radish, Horse-elder, Horseheal, Horseradish, Hu Lu Ba, Huang Ken, Huang Qin, Huckleberry, Humalog, Humalog Mix 75/25, Humulin, Humulin 50/50, Humulin 70/30, Hungarian chamomile, Hwanggum, Hydrocotyle asiatica, Iletin II, Iletin II Mixed, Imber, Indian Pennywort, Indian Saffron, Innohep, Insulin - 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How to use Glucosamine

Scientific Name: Glucosamine

Other Names: 2-Amino-2-Deoxyglucose, Chitosamine, Glucosamine Hydrochloride, Glucosamine Sulfate, N-acetyl Glucosamine

Who is this for?

Glucosamine is available in several different forms that are usually called “salts”. Most of the clinical studies investigating glucosamine’s medical effects have used a salt known as glucosamine sulfate, but other salts such as glucosamine hydrochloride and n-acetyl glucosamine are also sold widely. While all the salts of glucosamine contain the same general components, they may not all produce the same effects in the body. No studies have compared them, so not enough information is available about potential differences in their activity to know whether they are interchangeable.

Alone or combined with another dietary supplement called chondroitin, glucosamine has been studied extensively for treating osteoarthritis (OA), a condition that generally results from wear-and-tear on joints. In OA, deterioration of the cartilage, which cushions the joints, leads to pain, swelling, and loss of movement. Since glucosamine provides a major component of cartilage, it is believed that glucosamine may delay further degeneration. It may also actually help to repair deteriorating cartilage. Chondroitin is believed to provide a different chemical important in the formation of cartilage, but its effects are not as well defined as glucosamine’s. Although glucosamine has been studied most for treating OA of large joints such as knees and hips, it has also showed some effectiveness for relieving arthritis in the jaw, which is also known as the temporomandibular joint (TMJ).

Glucosamine is also important for healthy skin. Adequate amounts of it in the blood are necessary for the production of hyaluronic acid, one of the substances essential to heal skin injuries. Therefore, glucosamine plays a major role in the healing of surgical incisions and skin wounds. In a few studies, participants who began taking supplemental glucosamine before surgery and continued taking it until their incisions were completely healed showed generally faster healing with less scarring than other participants who did not take glucosamine. Wound dressings that contain a modified type of glucosamine known as poly-N-acetyl glucosamine are being studied to stop major bleeding. In other research, a few studies evaluating whether supplemental glucosamine helps to prevent or reverse wrinkling have had mixed results. Because natural production of hyaluronic acid decreases as individuals age, decreases in it may contribute to wrinkling of the skin. It is thought that increasing glucosamine may help the skin stay more resilient.

In a few small studies, n-acetyl glucosamine has shown promise for treating inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis. N-acetyl glucosamine forms part of an enzyme needed to produce mucus. Therefore, it is believed to increase the production of mucus that lines the lower gastrointestinal tract, providing a protective effect. More research for this possible use is needed.

When should I be careful taking it?

Very little information is available on how glucosamine might affect a developing fetus, an infant, or a small child. Therefore, its use is not recommended during pregnancy, while breast-feeding, or during early childhood.

The source of glucosamine is not required to be stated on the label. Since it may be made from crabs, lobsters, shrimp, or other shellfish; individuals who are allergic to these foods may also be allergic to glucosamine. Individuals with a sensitivity to shellfish should not use glucosamine.

Results from recent small studies showed no negative effects from glucosamine supplementation in individuals with diabetes. However, it is possible that glucosamine – particularly in doses higher than recommended amounts – may prompt the pancreas to produce less insulin as well as interfere with the use of insulin by muscle cells. In individuals with diabetes, blood sugar levels may become too high and diabetes may not be well controlled.

What side effects should I watch for?

The main side effects reported during clinical trials with all salts of glucosamine were mild and temporary gastrointestinal complaints such as constipation or diarrhea, cramping, gas, heartburn, and nausea. Drowsiness and headache were also associated with taking glucosamine sulfate.

What interactions should I watch for?

Recently, one case was reported of a tendency toward excessive bleeding in an individual taking both warfarin and a glucosamine/chondroitin supplement. Warfarin is an anticoagulant drug taken to prevent blood clots by “thinning the blood”. Although this possible interaction has not been confirmed, individuals who take anticoagulants or a related group of drugs known as antiplatelet agents should not take glucosamine.

  • Anticoagulants include heparin and warfarin
  • Antiplatelets include Plavix and Ticlid

Glucosamine may interfere with insulin and oral drugs for diabetes, such as:

  • Actos
  • Amaryl
  • Avandia
  • glipizide (Glucotrol XL)
  • glyburide (Glynase)
  • Glyset
  • metformin (Glucophage)
  • Prandin
  • Precose

Because glucose may increase blood sugar levels, taking it with herbal products that lower blood sugar may result in blood sugar that is too high or too low. Herbals that may reduce blood sugar include:

  • Eleuthero
  • Fenugreek
  • Ginger (in high amounts)
  • Kudzu
  • Panax Ginseng

Although no cases of interactions with other herbal anticoagulants have been reported with glucosamine, it is possible that the risk of excessive or uncontrolled bleeding may be slightly higher if glucosamine is used with other herbs that may decrease blood clotting. Some of the most common herbal products that might inhibit blood clotting are:

  • Danshen
  • Devil’s Claw
  • Eleuthero
  • Garlic
  • Ginger (in high amounts)
  • Ginkgo
  • Horse Chestnut
  • Panax Ginseng
  • Papain
  • Red Clover
  • Saw Palmetto

Some interactions between herbal products and medications can be more severe than others. The best way for you to avoid harmful interactions is to tell your doctor and/or pharmacist what medications you are currently taking, including any over-the-counter products, vitamins, and herbals.

Should I take it?

Glucosamine is a molecule that contains both sugar and protein. It is produced in the body, but its natural production slows down as individuals age. It is one of the essential components that the body uses in building and repairing tissues such as cartilage, heart valves, mucous membranes, and synovial fluid—the jelly-like substance that fills the joints. For supplemental use, glucosamine may be made in a laboratory. More often, however, it is obtained from natural sources such as the shells (also called exoskeletons) of crabs, lobsters, and other sea creatures.

Dosage and Administration

In the United States, glucosamine may be taken orally – typically as capsules and usually combined with chondroitin, manganese, vitamin C, or other dietary supplements. Occasionally, different salts of glucosamine may be combined into one product. Although study evidence does not prove that taking glucosamine and chondroitin together is more effective than glucosamine alone, the two products frequently are sold in combination. Less frequently, glucosamine is applied topically – again often in combination with chondroitin. In other countries, glucosamine is available in forms that may be injected into muscles or directly into joints.

By mouth, a typical daily dose of glucosamine ranges from 500 mg to 3,000 mg (one-half gram to 3 grams) per day. Many studies used glucosamine sulfate 500 mg three times a day to treat either OA or TMJ. Full effectiveness in controlling arthritis pain may take up to 4 weeks to develop after glucosamine has been started.

Note: Glucosamine and chondroitin are frequently sold in combination with the trace element manganese, because manganese is thought to be involved in cartilage production. A trace element is a substance that is required by the body in very small amounts for proper growth and functioning. However, care should be taken to limit manganese intake. The upper tolerable limit, which is the maximum amount that probably will not cause any side effects for most individuals taking manganese, has been set by the U.S. National Academy of Sciences at 11 mg per day for adults. Higher amounts of manganese may result in symptoms such as confusion, drooling, hallucinations, memory loss, stiff muscles, trembling, and other symptoms similar to Parkinson’s disease.


The major medical use of glucosamine – alone or with chondroitin – is to relieve joint pain and stiffness associated with osteoarthritis. It may help wounds to heal and some forms of glucosamine may also alleviate inflammatory bowel diseases.


Taking glucosamine derived from sea creatures may cause allergic responses in individuals who are allergic to shellfish. Individuals with diabetes may experience elevated blood sugar levels if they take glucosamine. Small children and pregnant or breast-feeding women may want to avoid taking glucosamine because little is known about its effects for these individuals.

Side Effects

Gastrointestinal complaints such as constipation, diarrhea, and nausea were attributed to taking glucosamine during studies. Some study participants who took glucosamine sulfate also reported drowsiness or headache.


Glucosamine may increase the risk of excessive bleeding when it is taken with warfarin, other anticoagulant or antiplatelet drugs, aspirin, or herbal products that reduce the blood’s ability to clot. It may also increase blood sugar levels, thereby interfering with drugs or herbals that lower blood sugar.


Anon: Glucosamine. In: DerMarderosian A, Beutler JA, eds. Facts and Comparisons: The Review of Natural Products. St. Louis, MO, Facts and Comparisons. September 2002.

Bailey CJ, Turner SL. Glucosamine-induced insulin resistance in L6 muscle cells. Diabetes, Obesity and Metabolism. 2004;6(4):293-298.

Balkan B, Dunning BE. Glucosamine inhibits glucokinase in vitro and produces a glucose-specific impairment of in vivo insulin secretion in rats. Diabetes. 1994;43(10):1173-1179.

Barclay TS, Tsourounis C, McCart GM. Glucosamine. Annals of Pharmacotherapy. 1998;32(5):574-579.

Barrett S. Glucosamine for arthritis. January 23, 2002. QuackWatch. Available at: Accessed September 27, 2004.

Blaurock-Busch E. The clinical effects of manganese (Mn). Townsend Letter for Doctors and Patients. No date given. Available at: Accessed September 23, 2003.

Braham R, Dawson B, Goodman C. The effect of glucosamine supplementation on people experiencing regular knee pain. British Journal of Sports Medicine. 2003;37(1):45-49.

Bruyere O, Pavelka K, Rovati LC, et al. Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies. Menopause. 2004;11(2):138-143.

Chen WY, Abatangelo G. Functions of hyaluronan in wound repair. Wound Repair and Regeneration. 1999;7(2):79-89.

Christgau S, Henrotin Y, Tanko LB, et al. Osteoarthritic patients with high cartilage turnover show increased responsiveness to the cartilage protecting effects of glucosamine sulphate. Clinical and Experimental Rheumatology. 2004;22(1):36-42.

Cole DJ, Connolly RJ, Chan MW, et al. A pilot study evaluating the efficacy of a fully acetylated poly-N-acetyl glucosamine membrane formulation as a topical hemostatic agent. Surgery. 1999;126(3):510-517.

Fraenkel L, Bogardus ST Jr, Concato J, Wittink DR. Treatment options in knee osteoarthritis: the patient's perspective. Archives of Internal Medicine. 2004;164(12):1299-1304.

Giaccari A, Morviducci L, Zorretta D, et al. In vivo effects of glucosamine on insulin secretion and insulin sensitivity in the rat: possible relevance to the maladaptive responses to chronic hyperglycaemia. Diabetologia. 1995;38(5):518-524.

Goa KL, Benfield P. Hyaluronic acid. A review of its pharmacology and use as a surgical aid in ophthalmology, and its therapeutic potential in joint disease and wound healing. Drugs. 1994;47(3):536-566.

Han DH, Chen MM, Holloszy JO. Glucosamine and glucose induce insulin resistance by different mechanisms in rat skeletal muscle. American Journal of Physiology, Endocrinology and Metabolism. 2003;285(6):E1267-E1272.

HealthNotes, Inc. Glucosamine. 2002. Available at: Accessed September 23, 2003.

HealthNotes, Inc. Glucosamine/Chondroitin. 2002. Available at: Accessed September 23, 2003.

Henderson CJ. Dietary Outcomes in Osteoarthritis Disease Management. Bulletin on the Rheumatic Diseases. 2003-2004;52(12): Available at: Accessed September 27, 2004.

Holmang A, Nilsson C, Niklasson M, et al. Induction of insulin resistance by glucosamine reduces blood flow but not interstitial levels of either glucose or insulin. Diabetes. 1999;48(1):106-111.

Houpt JB, McMillan R, Wein C, Paget-Dellio SD. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. Journal of Rheumatology. 1999;26(11):2423-2430.

Hughes R, Carr A. A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee. Rheumatology (Oxford). 2002;41(3):279-284.

Hungerford DS, Jones LC. Glucosamine and chondroitin sulfate are effective in the management of osteoarthritis. Journal of Arthroplasty. 2003;18(3 Suppl 1):5-9.

Institute of Medicine. U.S. National Academy of Sciences. Dietary reference intakes for vitamin A, vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Accessed September 23, 2003.

Jellin JM, Gregory P, Batz F, Hitchens K, et al, eds. Pharmacist's Letter/Prescriber's Letter. Natural Medicines Comprehensive Database, 3rd Edition. Stockton CA: Therapeutic Research Facility, 2000.

Lippiello L, Woodward J, Karpman R, Hammad TA. In vivo chondroprotection and metabolic synergy of glucosamine and chondroitin sulfate. Clinical Orthopedics. 2000;(381):229-240.

MacKay D, Miller AL. Nutritional support for wound healing. Alternative Medicine Review. 2003;8(4):359-377.

McAlindon T. Glucosamine and chondroitin for rheumatoid arthritis? Bulletin on the Rheumatic Diseases. 2001;50(7):1-4.

McAlindon T. Why are clinical trials of glucosamine no longer uniformly positive? Rheumatic Disease Clinics of North America. 2003;29(4):789-801.

McAlindon TE, LaValley MP, Gulin JP, Felson DT. Glucosamine and Chondroitin for Treatment of Osteoarthritis. A Systematic Quality Assessment and Meta-analysis. Journal of the American Medical Association. 2000;283(11):1469-1475.

McCarty MF. Glucosamine for wound healing. Medical Hypotheses. 1996;47(4):273-275.

McMillan DE. A brief history of the neurobehavioral toxicity of manganese: some unanswered questions. Neurotoxicology. 1999;20(2-3):499-507.

Miller DC, Richardson J. Does glucosamine relieve arthritis joint pain? Journal of Family Practice. 2003;52(8):645-647.

Monauni T, Zenti MG, Cretti A, et al. Effects of glucosamine infusion on insulin secretion and insulin action in humans. Diabetes. 2000;49:926-935.

Muller-Fassbender H, Bach GL, Haase W, Rovati LC, Setnikar I. Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee. Osteoarthritis and Cartilage. 1994;2(1):61-69.

Murad H, Tabibian MP. The effect of an oral supplement containing glucosamine, amino acids, minerals, and antioxidants on cutaneous aging: a preliminary study. Journal of Dermatology Treatment. 2001;12(1):47-51.

Nguyen P, Mohamed SE, Gardiner D, Salinas T. A randomized double-blind clinical trial of the effect of chondroitin sulfate and glucosamine hydrochloride on temporomandibular joint disorders: a pilot study. Cranio. 2001 Apr;19(2):130-139.

Nowlan C, Wetmore S. Short report: ibuprofen versus glucosamine sulfate. Treating osteoarthritis pain. Canadian Family Physician. 2003;49:1632-1634.

Nowak A, Szczesniak L, Rychlewski T, Dylewicz P, Przywarska I. Glucosamine levels in people with ischaemic heart disease with and without type II diabetes. Pol Arch Med Wewn. 1998;100(5):419-425.

Olszewski AJ, Szostak WB, McCully KS. Plasma glucosamine and galactosamine in ischemic heart disease. Atherosclerosis. 1990;82(1-20:75-83.

Pavelka K, Gatterova J, Olejarova M, Machacek S, Giacovelli G, Rovati LC. Glucosamine Sulfate Use and Delay of Progression of Knee Osteoarthritis: A 3-Year, Randomized, Placebo-Controlled, Double-blind Study. Archives of Internal Medicine. 2002;162(18):2113-2123.

Poustie MW, Carran J, McElerney K, Dixon SJ, Anastassiades TP, Bernier SM. N-butyryl glucosamine increases matrix gene expression by chondrocytes. Journal of Pharmacology and Experimental Therapeutics. July 7, 2004.

Priebe D, McDiarmid T, Mackler L, Tudiver F. Do glucosamine or chondroitin cause regeneration of cartilage in osteoarthritis? Journal of Family Practice. 2003;52(3):237-239.

Qiu GX, Gao SN, Giacovelli G, Rovati L, Setnikar I. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Arzneimittelforschung. 1998;48(5):469-474.

Reginster JY, Bruyere O, Lecart MP, Henrotin Y. Naturocetic (glucosamine and chondroitin sulfate) compounds as structure-modifying drugs in the treatment of osteoarthritis. Current Opinion in Rheumatology. 2003;15(5):651-655.

Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet. 2001;357(9252):251-256.

Richy F, Bruyere O, Ethgen O, Cucherat M, Henrotin Y, Reginster JY. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Archives of Internal Medicine. 2003;163(13):1514-1522.

Rozenfeld V, Crain JL, Callahan AK. Possible augmentation of warfarin effect by glucosamine-chondroitin. American Journal of Health-System Pharmacists. 2004;61(3):306-307.

Russell AL. Glucosamine in osteoarthritis and gastrointestinal disorders: an exemplar of the need for a paradigm shift. Medical Hypotheses. 1998;51(4):347-349.

Schwaitzberg SD, Chan MW, Cole DJ, Read M, Nichols T, Bellinger D, Connolly RJ. Comparison of poly-N-acetyl glucosamine with commercially available topical hemostats for achieving hemostasis in coagulopathic models of splenic hemorrhage. Journal of Trauma. 2004;57(1 Suppl):S29-S32.

Scott GN. Glucosamine-chondroitin interaction with warfarin. Pharmacist’s Letter/Prescriber’s Letter Detail Document #200305. March 2004.

Scroggie DA, Albright A, Harris MD. The effect of glucosamine-chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial. Archives of Internal Medicine. 2003;163(13):1587-1590.

Setnikar I, Palumbo R, Canali S, Zanolo G. Pharmacokinetics of glucosamine in man. Arzneimittelforschung 1993;43(10):1109-1113.

Shankar RR, Zhu JS, Baron AD. Glucosamine infusion in rats mimics the beta-cell dysfunction of non-insulin-dependent diabetes mellitus. Metabolism. 1998;47(5):573-577.

Shankland WE 2nd. The effects of glucosamine and chondroitin sulfate on osteoarthritis of the TMJ: a preliminary report of 50 patients. Cranio. 1998;16(4):230-135.

Shaunak S, Thomas S, Gianasi E, et al. Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation. Nature Biotechnology. 2004;22(8):977–984.

Soeken KL. Selected CAM therapies for arthritis-related pain: the evidence from systematic reviews. Clinical Journal of Pain. 2004;20(1):13-18.

Tallia AF, Cardone DA. Asthma exacerbation associated with glucosamine-chondroitin supplement. Journal of the American Board of Family Practice. 2002;15(6):481-484.

Tannis AJ, Barban J, Conquer JA. Effect of glucosamine supplementation on fasting and non-fasting plasma glucose and serum insulin concentrations in healthy individuals. Osteoarthritis and Cartilage. 2004;12(6):506-511.

Thie NM, Prasad NG, Major PW. Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint osteoarthritis: a randomized double blind controlled 3 month clinical trial. Journal of Rheumatology. 2001;28(6):1347-1355.

Towheed TE, Anastassiades TP, Shea B, Houpt J, Welch V, Hochberg MC. Glucosamine therapy for treating osteoarthritis. Cochrane Database System Review. 2001;(1):CD002946.

Vournakis JN, Demcheva M, Whitson AB, Finkielsztein S, Connolly RJ. The RDH bandage: hemostasis and survival in a lethal aortotomy hemorrhage model. Journal of Surgical Research. 2003;113(1):1-5.

Wells L, Vosseller K, Hart GW. A role for N-acetylglucosamine as a nutrient sensor and mediator of insulin resistance. Cellular and Molecular Life Sciences. 2003;60(2):222-228.

Winslet MC, Poxon V, Allan A, Keighley MR. Mucosal glucosamine synthetase activity in inflammatory bowel disease. Digestive Disease Science. 1994;39(3):540-544.

Yun J, Tomida A, Nagata K, Tsuruo T. Glucose-regulated stresses confer resistance to VP-16 in human cancer cells through a decreased expression of DNA topoisomerase II. Oncology Research. 1995;7(12):583-590.

Zerkak D, Dougados M. The use of glucosamine therapy in osteoarthritis. Current Rheumatology Reports. 2004;6(1):41-45.

(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

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