Known interactions

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Info about Ibuprofen and Pseuodoephedrine

Brand Name(s): Advil Cold & Sinus, Advil Flu & Body Ache, Dristan Sinus, Motrin Sinus Headache

Generic Name Ibuprofen and Pseuodoephedrine

What are ibuprofen; pseudoephedrine tablets or caplets?

IBUPROFEN; PSEUDOEPHEDRINE (Advil Cold & Sinus®, Dimetapp® Sinus, Dristan® Sinus, Motrin® IB Sinus, Sine-Aid® IB,Vicks Dayquil® Sinus Pressure & Pain Relief with Ibuprofen) is a decongestant, fever-reducer and pain-reliever. It can help relieve nasal or sinus congestion (stuffiness), fever, body aches or mild pain, sore throat, and headache associated with the common cold, flu, or sinusitis. Generic ibuprofen; pseudoephedrine tablets are not yet available.

What should my health care professional know before I take ibuprofen; pseudoephedrine?

They need to know if you have any of the following conditions:

  • anemia
  • asthma
  • cigarette smoker
  • dental disease
  • diabetes
  • difficulty urinating (urinary retention)
  • drink more than 3 alcohol-containing beverages a day
  • glaucoma
  • heart disease or circulation problems (e.g., heart failure, heart rhythm problems)
  • high blood pressure
  • immunosupression (suppressed immune function)
  • kidney disease
  • liver disease
  • nasal polyps
  • over active thyroid
  • prostate trouble
  • stomach bleeding or ulcers
  • taking blood thinners
  • taking hormones such as prednisone (steroids)
  • ulcerative colitis
  • an unusual or allergic reaction to ibuprofen, pseudoephedrine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I take this medicine?

Take ibuprofen; pseudoephedrine tablets or caplets by mouth.Swallow tablets whole with a full glass of water; take tablets in an upright or sitting position. Taking a sip of water first, before taking the tablets, may help you swallow them. If possible take bedtime doses at least 10 minutes before lying down. Ibuprofen products may be taken with food if it upsets your stomach. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

Elderly patients over 60 years old may have a stronger reaction to this medicine and need smaller doses.

What if I miss a dose?

If you miss a dose, and you are taking it on a regular schedule, take it as soon as you can. If it is almost time for your next dose (less than 2 hours), take only that dose. Do not take double or extra doses.

What drug(s) may interact with ibuprofen; pseudoephedrine?

  • alcohol
  • ammonium chloride
  • amphetamine or other stimulant drugs
  • antiinflammatory drugs such as naproxen (Aleve® or prednisone)
  • bicarbonate, citrate, or acetate products (such as sodium bicarbonate, sodium acetate, sodium citrate, sodium lactate, and potassium citrate)
  • bromocriptine
  • caffeine
  • cidofovir
  • cocaine
  • cyclosporine
  • entecavir
  • furazolidone
  • linezolid
  • lithium
  • medicines for colds and breathing difficulties
  • medicines for diabetes
  • medicines known as MAO inhibitors, such as phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®), and selegiline (Carbex®, Eldepryl®)
  • medicines for mental depression
  • medicines for migraine
  • medicines that affect platelets
  • medicines that treat or prevent blood clots such as warfarin and other 'blood thinners'
  • methotrexate
  • pemetrexed
  • procarbazine
  • some medicines for chest pain, heart disease, high blood pressure or heart rhythm problems
  • some medicines for weight loss (including some herbal products, ephedrine, dextroamphetamine)
  • St. John's wort
  • theophylline
  • thyroid hormones
  • water pills (diuretics)

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check before starting or stopping any of your medicines.

What side effects may I notice from taking ibuprofen; pseudoephedrine?

Side effects that you should report to your prescriber or health care professional as soon as possible:

Rare or uncommon:

  • blurred vision or visual changes
  • chest pain
  • confusion
  • dizziness or fainting spells
  • neck stiffness
  • numbness or tingling in the hands or feet
  • rapid or troubled breathing
  • ringing in the ears
  • seizures
  • severe, persistent, or worsening headache
  • signs of decreased platelets or bleeding - bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine or stools, unusual tiredness or weakness
  • signs of an allergic reaction - difficulty breathing, wheezing, skin rash, redness, blistering, peeling or itching, swelling of eyelids, throat, lips or feet
  • yellowing of the skin or eyes

More Common:

  • anxiety or nervousness
  • cold, clammy skin
  • difficulty swallowing
  • fever, chills, muscle aches and pains
  • high blood pressure
  • increased sweating
  • irregular heartbeat (fast or slow heartbeat), palpitations
  • pain or difficulty passing urine
  • stomach pain, tenderness, bleeding, or cramps
  • sleeplessness (insomnia)
  • swelling of eyelids, throat, lips, legs, ankles, or feet
  • tremor or muscle contractions
  • unexplained weight gain or fluid retention
  • vomiting

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • constipation or diarrhea
  • difficulty sleeping
  • drowsiness
  • gas or heartburn
  • increased sensitivity to sunlight
  • loss of appetite
  • minor upset stomach, nausea
  • restlessness

What should I watch for while taking ibuprofen; pseudoephedrine?

Check with your prescriber or health care professional if your symptoms have not improved within 7 days, or if you have a high fever. Do not treat yourself for a fever with ibuprofen for more than 3 days, or for pain for more than 10 days without asking your prescriber or health care professional for advice. You may be covering up a more serious illness.

If ibuprofen; pseudoephedrine makes it difficult for you to sleep at night; take your last dose at least a few hours before bedtime. If nervousness, dizziness, or sleeplessness occur, stop using this product and consult a health care professional.

If you are going to have surgery, tell your prescriber or health care professional that you are taking ibuprofen. Problems can arise if you need dental work, and in the day to day care of your teeth. Try to avoid damage to your teeth and gums when you brush or floss your teeth.

To reduce unpleasant effects on your throat and stomach, take ibuprofen products with a full glass of water and never just before lying down.

Do not smoke cigarettes or drink alcohol; these may increase the irritation to your stomach when taking this medicine.

You may get dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how ibuprofen; pseudoephedrine affects you. Do not sit or stand up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

It is especially important not to use ibuprofen products during the last 3 months of pregnancy unless specifically directed to do so by your health care provider. Ibuprofen may cause problems in the unborn child or complications during delivery.

Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open.

Store at room temperature, between 20 and 25 °C (68 and 77 °F), unless otherwise specified on the product label. Protect from heat and moisture. Throw away any unused medicine after the expiration date.

(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

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