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Application of Ibuprofen; Oxycodone tablets

Brand Name(s): Combunox

Generic Name Ibuprofen; Oxycodone tablets

What are Ibuprofen; Oxycodone tablets?

IBUPROFEN; OXYCODONE (Combunox™) is a combination of two different types of pain medicine and is used to treat moderate to severe pain. Federal law prohibits the transfer of this product to any person other than the patient for whom it was prescribed. Generic ibuprofen; oxycodone tablets are not available.

What should my health care professional know before I receive Ibuprofen; Oxycodone?

They need to know if you have any of these conditions:

  • anemia
  • asthma
  • bleeding problems
  • dental disease
  • diabetes
  • diarrhea
  • drink more than 3-alcohol containing beverages a day
  • head injury
  • heart or circulation problems
  • kidney disease
  • liver disease
  • lung disease or breathing difficulties
  • nasal polyps
  • seizures
  • stomach or duodenal ulcers
  • systemic lupus erythematosus
  • ulcerative colitis
  • an unusual or allergic reaction to oxycodone, ibuprofen, other medicines, foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should this medicine be used?

Take ibuprofen; oxycodone combination tablets by mouth. Follow the directions on the prescription label. Swallow tablets whole with a full glass of water; take tablets in an upright or sitting position. Taking a sip of water first, before taking the tablets, may help you swallow them. If possible take bedtime doses at least 10 minutes before lying down. You can take this medicine with food to prevent stomach upset. Do not take your medicine more often than directed.

Contact your pediatrician or health care professional regarding the use of this medicine in children under 14 years of age. Special care may be needed.

Do not share this medicine with anyone.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What drug(s) may interact with Ibuprofen; Oxycodone?

  • antiinflammatory drugs (other NSAIDs)
  • aspirin and aspirin-like medicines
  • cyclosporine
  • entecavir
  • herbal products that contain feverfew, garlic, ginger, or ginkgo biloba
  • hormones such as prednisone or cortisone
  • lithium
  • medicines for diabetes that are taken by mouth
  • medicines for high blood pressure
  • medicines that affect platelets
  • medicines that treat or prevent blood clots such as warfarin and other 'blood thinners'
  • medicines for seizures
  • methotrexate
  • pemetrexed
  • water pills (diuretics)

Because oxycodone can cause drowsiness, other medicines that also cause drowsiness may increase this effect of ibuprofen; oxycodone combination products. Some other medicines that cause drowsiness are:

  • alcohol-containing medicines
  • barbiturates such as phenobarbital
  • certain antidepressants or tranquilizers
  • muscle relaxants
  • certain antihistamines used in cold medicines

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from receiving Ibuprofen; Oxycodone?

Side effects that you should report to your prescriber or health care professional as soon as possible:

  • signs of bleeding - bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine, unusual tiredness or weakness
  • signs of an allergic reaction - difficulty breathing, wheezing, skin rash, redness, blistering, peeling or itching, swelling of eyelids, throat, lips or feet
  • change in the amount of urine passed
  • chest pain
  • cold, clammy skin
  • confusion
  • fast heartbeat
  • fever, chills, muscle aches and pains
  • lightheadedness or fainting spells
  • nervousness or restlessness
  • pain or difficulty passing urine
  • seizures
  • slow or fast heart beat
  • stomach pain or cramps

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • confusion
  • constipation
  • diarrhea
  • dizziness, drowsiness
  • flushing
  • gas or heartburn
  • headache
  • itching
  • nausea, vomiting

What should I watch for while taking Ibuprofen; Oxycodone?

Tell your prescriber or health care professional if your pain does not go away, if it gets worse, or if you have new or different type of pain. Do not take other pain medicines with ibuprofen; oxycodone combinations without advice. Many non-prescription pain medicines contain ibuprofen as an ingredient. Always read the labels carefully to avoid taking too much ibuprofen. Use exactly as directed by your prescriber or health care professional. Do not take more than the recommended dose.

If you are receiving cancer chemotherapy or other immunosuppression medicine, do not take ibuprofen; oxycodone combination products with out checking with your prescriber or health care professional. These products may hide the signs of an infection such as fever or pain.

To reduce unpleasant effects on your throat and stomach, take ibuprofen; oxycodone combination products with a full glass of water and never just before lying down. You may also take it with food or milk.

Ibuprofen; oxycodone combination products may make you drowsy when you first start taking it or change doses. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not sit or stand up quickly. This reduces the risk of dizzy or fainting spells. These effects may be worse if you are an older patient. The drowsiness should decrease after taking the medicine for a couple of days. If you have not slept because of your pain, you may sleep more the first few days your pain is controlled to catch-up on missed sleep.

Be careful taking other medicines that may also make you tired. This effect may be worse when taking these medicines with ibuprofen; oxycodone combination products. Alcohol can increase drowsiness, dizziness, confusion and affect your breathing. Avoid alcohol while taking ibuprofen; oxycodone combination products.

Do not smoke cigarettes or drink alcohol; these may increase the irritation to your stomach when taking this medicine. If you get black, tarry stools or vomit up what looks like coffee grounds, call your prescriber or health care professional at once.

Ibuprofen; oxycodone combination products can cause constipation. Make sure to take a laxative and/or a stool softener. Try to have a bowel movement at least every 2—3 days. If you do not have a bowel movement for 3 days or more call your prescriber or health care professional. They may recommend using an enema or suppository to help you move your bowels.

It is especially important not to use ibuprofen; oxycodone combination products during the last 3 months of pregnancy unless specifically directed to do so by your health care provider. Ibuprofen and oxycodone might cause problems in the unborn child or complications during delivery.

If you are going to have surgery, tell your prescriber or health care professional that you are taking ibuprofen; oxycodone combination products. Ibuprofen can cause you to bleed more easily. Problems can arise if you need dental work, and in the day to day care of your teeth. Try to avoid damage to your teeth and gums when you brush or floss your teeth.

Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open. Do not share or give this medicine to anyone else. Avoid accidental swallowing of Combunox™ by someone (especially children) other than for whom it was prescribed as this may result in severe side effects and possibly death.

Store at 25 °C (77 °F). Keep container tightly closed. Protect from light. Throw away any unused medicine after the expiration date.


(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

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