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Information about Ifex

Brand Name(s): Ifex

Generic Name Ifosfamide

What is ifosfamide injection?

IFOSFAMIDE (Ifex®) is a type of chemotherapy for treating cancer. Ifosfamide is changed by the liver into a substance that interferes with the growth of rapidly dividing cells, like cancer cells, and eventually causes these cells to die. Ifosfamide is used in combination with other chemotherapy agents to treat cancer of the testes and other cancers. Ifosfamide may also be given as part of regimen prior to stem cell transplantation. Another medicine called mesna is used with ifosfamide to prevent bleeding in the bladder. Generic ifosfamide injection is available.

What should my health care professional know before I receive ifosfamide?

They need to know if you have any of these conditions:

  • bleeding problems
  • blood disorders
  • cystitis
  • dehydration
  • dental disease
  • infection (especially virus infection such as chickenpox or herpes)
  • kidney disease
  • liver disease
  • previous treatment with cisplatin or carboplatin
  • recent radiation therapy
  • an unusual or allergic reaction to ifosfamide, other chemotherapy, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Ifosfamide is for slow infusion into a vein. It is usually administered in a hospital or clinic setting by a health care professional. It can be given by a trained nurse as part of home health-care services.

What if I miss a dose?

It is important not to miss a dose. Notify your prescriber or health care professional if you are unable to keep an appointment.

What drug(s) may interact with ifosfamide?

  • live virus vaccines
  • other chemotherapy agents may increase the side effects seen with ifosfamide

Talk to your prescriber or health care professional before taking any of these medicines:

  • aspirin
  • acetaminophen
  • ibuprofen
  • naproxen
  • ketoprofen

Tell your prescriber or health care professional about all other medicines you are taking, including nonprescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from receiving ifosfamide?

The side effects you may experience with ifosfamide therapy depend upon the dose, other types of chemotherapy or radiation therapy given, and the disease being treated. Not all of these effects occur in all patients. Discuss any concerns or questions with your prescriber or health care professional.

Side effects that you should report to your prescriber or health care professional as soon as possible:

  • low blood counts - ifosfamide may decrease the number of white blood cells, red blood cells and platelets. You may be at increased risk for infections and bleeding.
  • signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine
  • signs of decreased platelets or bleeding - bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine
  • signs of decreased red blood cells - unusual weakness or tiredness, fainting spells, lightheadedness
  • confusion, hallucinations
  • dizziness, drowsiness
  • increase in the amount of urine passed
  • pain, swelling, redness or irritation at the injection site
  • rapid or irregular heart beat
  • seizures (convulsions)

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • hair loss
  • loss of appetite
  • nausea
  • vomiting

What should I watch for while taking ifosfamide?

Visit your prescriber or health care professional for checks on your progress. You will need to have regular blood checks. The side effects of ifosfamide can continue after you finish your treatment; report side effects promptly.

Ifosfamide may make you feel generally unwell. This is not uncommon because ifosfamide affects good cells as well as cancer cells. Report any side effects as above, but continue your course of medicine even though you feel ill, unless your prescriber or health care professional tells you to stop.

Ifosfamide may decrease your body's ability to fight infections. Call your prescriber or health care professional if you have a fever, chills, sore throat or other symptoms of a cold or flu. Do not treat these symptoms yourself. Try to avoid being around people who are sick. Ifosfamide may increase your risk to bruise or bleed. Call your prescriber or health care professional if you notice any unusual bleeding. Be careful not to cut, bruise or injure yourself because you may get an infection and bleed more than usual.

Be careful brushing and flossing your teeth or using a toothpick while receiving ifosfamide because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving ifosfamide.

Avoid taking aspirin, acetaminophen (Tylenol®), ibuprofen (Advil®), naproxen (Aleve®), or ketoprofen (Orudis® KT) products as these may hide a fever, unless instructed to by your prescriber or health care professional.

Drink several glasses of water a day. This will help to reduce possible kidney and bladder problems. Empty your bladder regularly, especially at night.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how ifosfamide affects you.

If you are going to have surgery, tell your prescriber or health care professional that you are using ifosfamide.

Where can I keep my medicine?

This does not apply. You will usually receive this medicine in a clinic or hospital.


(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

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