Known interactions

Bellacane SR, Belladonna Alkaloids, Ergotamine, and Phenobarbital Tablets, Bellaspas, Bellergal-S, Cafatine PB, Cafatine Suppositories, Cafergot, Cafergot Suppositories, Cafetrate Suppositories, Celexa, Celexa Solution, Citalopram, Citalopram Oral Solution, Citalopram orally-disintegrating tablets, citalopram orally-disintegrating tablets, D.H.E. 45 Injection, Dihydroergotamine Injection, Dihydroergotamine Nasal Spray, Effexor, Ercaf, Ergo-Caff, Ergomar, Ergotamine and Caffeine Rectal Suppositories, Ergotamine Sublingual Tablets, Ergotamine Tartrate and Caffeine, Fluoxetine and Olanzapine, Fluoxetine capsules (Sarafem), Fluoxetine Oral Solution, Fluoxetine tablets or capsules, Fluvoxamine, Folergot-DF, fluoxetine delayed-release capsules, Isocarboxazid, Luvox, Marplan, Meridia, Methysergide, Migergot, Migranal, Nardil, Nefazodone, Parnate, Paroxetine, Paroxetine Oral Suspension, Paxil, Paxil CR, Paxil Suspension, Phenelzine, Phenerbel-S, Prozac, Prozac Oral Solution, Prozac Weekly, Sansert, Sarafem, Sertraline, Sertraline Oral Solution, Serzone, Sibutramine, Spastrin, Symbyax, Tranylcypromine, Venlafaxine, Wigraine, Wigraine Suppositories, Zoloft, Zoloft Oral Solution.

How to use Imitrex Nasal Spray

Brand Name(s): Imitrex Nasal Spray

Generic Name Sumatriptan Nasal Spray

What is sumatriptan nasal spray?

SUMATRIPTAN (Imitrex®) helps to relieve a migraine attack that starts with or without aura (a peculiar feeling or visual disturbance that warns you of an attack). Sumatriptan is not used to prevent migraine attacks. Generic sumatriptan nasal spray is not yet available.

What should my health care professional know before I take sumatriptan?

They need to know if you have any of these conditions:

  • bowel disease or colitis
  • diabetes
  • headaches that are different from your usual migraine
  • heart or blood vessel disease, angina (chest pain), or previous heart attack
  • family history of heart disease
  • high blood pressure
  • high cholesterol
  • history of stroke, transient ischemic attacks (TIAs or "mini-strokes"), or intracranial bleeding
  • fast or irregular heartbeat
  • postmenopausal or surgical removal of uterus and ovaries
  • liver disease
  • overweight
  • poor circulation
  • Raynaud's disease
  • seizure disorder
  • shortness of breath
  • tobacco smoker
  • an unusual or allergic reaction to sumatriptan, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I take this medicine?

Follow the directions on the prescription label. Sumatriptan is given at the first symptoms of a migraine attack; it is not for everyday use. If your migraine headache returns after one dose, you can take another dose at least 2 hours after the first dose. Do not use more than 40 mg total of this spray in any 24 hour period. Since sumatriptan nasal spray comes in different strengths, check with your pharmacist to see how many sprays you can use in a day of your prescription that equal 40 mg. If there is no improvement at all after the first dose, do not take a second dose without talking to your prescriber or health care professional. Do not take your medicine more often than directed.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

This does not apply, sumatriptan is not for regular use.

What drug(s) may interact with sumatriptan?

Do not take sumatriptan with any of the following medicines:

  • amphetamine or cocaine
  • dihydroergotamine, ergotamine, eroloid mesylates, methysergide, or ergot-type medication - do not take within 24 hours of taking sumatriptan.
  • almotriptan, eletriptan, naratriptan, rizatriptan, zolmitriptan - do not take within 24 hours of taking sumatriptan.
  • medicines for weight loss such as dexfenfluramine, dextroamphetamine, fenfluramine, or sibutramine
  • monoamine oxidase inhibitors (MAOIs) such as phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®), and selegiline (Carbex®, Eldepryl®) - do not take sumatriptan within 2 weeks of stopping MAOI therapy.

Check with your doctor or pharmacist if you take any of these medications:

  • cough syrup or other products containing dextromethorphan
  • feverfew
  • lithium
  • medicines for mental depression, anxiety or mood problems such as buspirone, citalopram, fluoxetine, fluvoxamine, mirtazapine, nefazodone, paroxetine, sertraline, trazodone, tricyclic antidepressants, or venlafaxine
  • meperidine
  • propranolol
  • St. John's wort
  • tryptophan

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from taking sumatriptan?

Side effects that you should report to your prescriber or health care professional as soon as possible:

Rare or uncommon:

  • chest or throat pain, tightness
  • dizziness or faintness
  • fast, slow, or irregular heart beat
  • feeling of chest heaviness or pressure
  • increased or decreased blood pressure
  • loss of vision or vision changes
  • palpitations
  • seizures (convulsions)
  • severe stomach pain and cramping, bloody diarrhea
  • shortness of breath, wheezing, or difficulty breathing
  • tingling, pain, or numbness in the face, hands or feet
  • unusual reaction or swelling of the skin, eyelids, face, or lips

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • change in taste
  • diarrhea
  • drowsiness
  • feeling warm, flushing, or redness of the face
  • muscle pain or cramps
  • nausea, vomiting, or stomach upset
  • tiredness or weakness

What should I watch for while taking sumatriptan?

Only use sumatriptan nasal spray for a migraine headache. Use it if you get warning symptoms or at the start of a migraine attack. Sumatriptan is not for regular use to prevent migraine attacks.

Do not take migraine products that contain ergotamine while you are taking sumatriptan; this combination can affect your heart.

You may get drowsy, dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how sumatriptan affects you. To reduce dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Alcohol can increase drowsiness, dizziness and flushing. Avoid alcoholic drinks.

Smoking cigarettes may increase the risk of heart-related side effects from using sumatriptan.

Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open.

Store at room temperature between 15 and 30 °C (59 and 86 °F). Throw away any unused medicine after the expiration date.

(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

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