Known interactions

Absinthe, Accubron Syrup, Accurbron, Acebutolol, Achillea, Achillea millefolium, Activated Charcoal, Actonel, Actonel with calcium, African Pepper, Ajenjo, AKTob, Alendronate and cholecalciferol, Alendronate Oral Solution, Alendronate tablets, Alendronate weekly tablets, Amethopterin, Amigesic, Amikacin Sulfate Injection, Amikin, Aminophylline (Theophylline) Injection, Aminophylline Tablets, Amitone, Anafranil, Aquaphyllin, Aquaphyllin Syrup, Aredia, Argesic-SA, Armoise, Artemisia absinthium, Artha-G, Arthropan, Asmalix, Asmalix Elixir, Aspirin and Carisoprodol, Aspirin, Caffeine and Dihydrocodeine, Atazanavir, Atenolol, Atenolol and Chlorthalidone, Atenolol Injection, Axid AR, Axid Capsules, Axid Oral Solution, Baclofen Injection, Baclofen Oral, Benemid, Betapace, Betapace AF, Betaxolol Ophthalmic, Betaxolol Oral, Betimol, Betoptic, Betoptic S, Biaxin, Biaxin Suspension, Biaxin XL, Bird Pepper, Bisoprolol, Bitter Thistle, Blessed thistle, Blocadren, Bloodwort, Blowball, Brevibloc, Bronkodyl, Buffered Aspirin and Pravastatin, Caffeine, Aspirin and Dihydrocodeine, Calcium Carbonate Tablets, Caltrate 600, Canker Wort, Capsicum, Capsicum annuum, Capsicum frutescens, Carafate, Carafate Oral Suspension, Carbenia Benedicta, Cardo Santo, Carisoprodol Compound, Carteolol, Carteolol Ophthalmic, Cartrol, Celexa, Celexa Solution, CharcoAid, Charcoal, Charcoal capsules, Charcoal Plus, Charcoal powder or oral suspension, CharcoCaps, Chili Pepper, Choline Magnesium Trisalicylate, Choline Salicylate and Magnesium Salicylate Solution, Choline Salicylate oral solution, Chroma-Pak injection, Chromic Chloride injection, Chromium, Chromium 3, Chromium Acetate, Chromium Chloride, Chromium chloride injection, Chromium injection, Chromium Picolinate, Cimetidine, Cimetidine Injection, Cimetidine Liquid, Citalopram, Citalopram Oral Solution, Citalopram orally-disintegrating tablets, Clarithromycin, Clarithromycin Suspension, Clomipramine, Cnicus benedictus, Corgard, Corzide, Cosopt, Coumadin, Coumadin Injection, Creatine, Creatine Citrate, Creatine Monohydrate, Creatine Phosphate, Crixivan, Curcuma, Curcuma species, Cyclosporine, Cyclosporine Injection, Cyclosporine Ophthalmic, Cyclosporine Oral Solution, citalopram orally-disintegrating tablets, Dandelion, Defy, Detrol, Detrol LA, Devil's Claw, Dicarbosil, Didronel, Didronel Injection, Digitek, Digoxin, Digoxin Injection, Digoxin Liquid, Dihydrocodeine, Aspirin and Caffeine, Disalcid, Dorzolamide and Timolol Ophthalmic, Elixomin, Elixomin Elixir, Elixophyllin, Elixophyllin Elixir, Equilet, Escitalopram, Escitalopram Oral Solution, Eskalith, Eskalith CR, Esmolol, Etidronate Disodium, Etidronate Disodium Injection, Eyebalm, Famotidine, Famotidine Injection, Famotidine Oral Suspension, FK 506, Fluoxetine and Olanzapine, Fluoxetine capsules (Sarafem), Fluoxetine Oral Solution, Fluoxetine tablets or capsules, Fluvoxamine, Fosamax, Fosamax 35, Fosamax 70, Fosamax Oral Solution, Fosamax Plus D, fluoxetine delayed-release capsules, Garamycin Cream, Garamycin Injection, Garamycin Opthalmic, Gengraf, Gengraf Solution, Genoptic, Gentacidin, Gentafair, Gentak, Gentamicin Ophthalmic Drops or Ointment, Gentamicin Sulfate Injection, Gentamicin Topical, Ginkgo, Ginkgo Biloba, Goat's Pod, Goldenseal, Grapple Plant, Green Arrow, Green Ginger, Ground Raspberry, Harpagophytum procumbens, Holy Ghost Herb, Inderal, Inderal IV, Indian Saffron, Indinavir, Intraconazole Injection, Irish Daisy, Itraconazole, Itraconazole Oral Solution, Jantoven, Japanese Silver Apricot, Jenamicin Injection, Kerlone Oral, Ketoconazole Oral, Ketoconazole Shampoo, Ketoconazole Topical, Kew Tree, Lanophyllin, Lanophyllin Elixir, Lanoxicaps, Lanoxin, Lanoxin Injection, Lanoxin Liquid, Lansoprazole, Clarithromycin and Amoxicillin, Latanoprost; Timolol eye solution, Leotodon taraxacum, Levatol, Lexapro, Lexapro Oral Solution, Lion's Tooth, Lioresal, Lioresal Injection, Lithane, Lithium, Lithium Oral Syrup, Lithium, Extended-Release, Lithobid, Lithonate, Lithotabs, Lopressor, Lopressor HCT, Lopressor Injection, Luvox, Madderwort, Magan, Magnesium Salicylate, Maidenhair Tree, Mallamint, Marthritic, Mentha piperita, Methotrexate, Methotrexate Injection, Metoprolol and Hydrochlorothiazide, Metoprolol ER, Metoprolol Injection, Metoprolol Oral, Mexican Chillies, Milfoil, Mobidin, Momentum, Monogesic, MTX Injection, Nadolol, Nadolol and Bendroflumethiazide, Nebcin, Neoral, Neoral Injection, Neoral Solution, Nizatadine Capsules, Nizatadine Oral Solution, Nizoral Cream, Nizoral Shampoo, Nizoral Tablets, Nosebleed Plant, Ocu-Mycin, Ocupress, Orangeroot, Pamidronate Injection, Paprika, Paroxetine, Paroxetine Oral Suspension, Paxil, Paxil CR, Paxil Suspension, Penbutolol, Pepcid AC, Pepcid Injection, Pepcid Oral, Pepcid Oral Suspension, Peppermint, Pindolol, Pravigard PAC, Prevpac, Probalan, Probenecid, Prograf, Prograf Injection, Propranolol, Propranolol Injection, Propranolol Oral Solution, Protopic, Prozac, Prozac Oral Solution, Prozac Weekly, Puffball, Quibron-T Dividose, Quibron-T/SR Dividose, Ranitidine, Ranitidine Effervescent Tablets or Granules, Ranitidine Hydrochloride Injection, Ranitidine Oral Syrup, Red Pepper, Respbid, Restasis, Reyataz, Rheumatrex, Risedronate, Risedronate with calcium carbonate, Salflex, Salgesic, Salsalate, Salsitab, Sandimmune, Sandimmune Injection, Sandimmune Solution, Sarafem, Sectral, Sertraline, Sertraline Oral Solution, Skelid, Slo-bid Gyrocaps, Slo-Phyllin, Slo-Phyllin Gyrocaps, Slo-Phyllin Syrup, Sodium Thiosulfate and Salicylic Acid Lotion, Sodol Compound, Soma Compound, Sotalol, Sporanox, Sporanox Injection, Sporanox Oral Solution, Spotted Thistle, St. Benedict's Thistle, Staunch Weed, Streptomycin, Sucralfate, Sucralfate Oral Suspension, Sustaire, Symbyax, Synalgos-DC, T-Phyl, Tabasco Pepper, Tacrolimus, Tacrolimus Injection, Tacrolimus ointment, Tagamet, Tagamet HB, Tagamet Injection, Tagamet Liquid, Taraxacum officinale, Tenoretic, Tenormin, Tenormin Injection, Theo-24, Theo-Dur, Theo-Sav, Theo-X, Theobid Duracaps, Theochron, Theoclear L.A., Theoclear-80, Theoclear-80 Syrup, Theolair, Theolair Injection, Theolair Solution, Theolair SR, Theophylline ER, Theophylline Injection, Theophylline Oral Solution, Syrup, or Suspension, Theophylline Tablets or Capsules, Theospan-SR, Theostat 80, Theostat-80 Syrup, Theovent, Thousand-Leaf, Tiludronate, Timolol Ophthalmic, Timolol Oral, Timoptic, Timoptic-XE, Titralac, TOBI, TobraDex, Tobramycin and Dexamethasone Ophthalmic, Tobramycin Inhalation Solution, Tobramycin Ophthalmic Drops, Tobramycin Ophthalmic Ointment, Tobramycin Sulfate Injection, Tobrex Eye Drops, Tobrex Eye Ointment, Tolterodine, Toprol XL, Trexall, Trilisate Solution, Trivalent Chromium, Trovafloxacin, Trovan Oral, Tums, Turmeric, Uni-Dur, Uniphyl, Vantage, Versiclear, Visken, Warfarin, Warfarin injection, Wermut, Wild Endive, Wood Spider, Wormwood, Wound Wort, Xalcom, Yarrow, Yarroway, Yellowroot, Yinhsing, Zantac, Zantac 75, Zantac EFFERdose, Zantac Injection, Zantac Syrup, Zanzibar Pepper, Zebeta, Zoloft, Zoloft Oral Solution, Food and alcohol.

Information about Lansoprazole and Naproxen

Brand Name(s): Prevacid NapraPAC

Generic Name Lansoprazole and Naproxen

What are Lansoprazole; Naproxen tablets and capsules?

NAPROXEN; LANSOPRAZOLE (Prevacid® NapraPAC™) is a combination of medications used to treat pain associated with osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis. The Prevacid® NapraPAC™ 'kit' contains Naprosyn® (naproxen tablets), and Prevacid® (lansoprazole capsules) packaged together. Generic Prevacid® NapraPAC™ therapy kits are not available.

What should my health care professional know before I receive Lansoprazole; Naproxen?

They need to know if you have any of these conditions:

  • anemia
  • asthma, especially aspirin sensitive asthma
  • bleeding problems or taking medicines that make you bleed easily such as anticoagulants ('blood thinners')
  • cigarette smoker
  • diabetes
  • drink more than 3 alcohol-containing beverages a day
  • heart failure
  • high blood pressure
  • kidney disease
  • liver disease
  • stomach or duodenal ulcers
  • systemic lupus erythematosus
  • ulcerative colitis
  • an unusual or allergic reaction to naprosyn, aspirin or other NSAIDs, lansoprazole or other proton pump inhibitors, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should this medicine be used?

Each daily 'dose' of Prevacid® NapraPAC™ contains three pills: one pink and green capsule (Prevacid®) and two pink tablets (Naprosyn® 375) or two yellow tablets (Naprosyn® 500). One tablet should be taken in the moning before breakfast along with the capsule. The other tablet should be taken in the early evening. Follow the directions on the prescription label. Swallow capsules and tablets whole with a drink of water; do not crush or chew. Take your doses at regular intervals. Do not take your medicine more often than directed.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What drug(s) may interact with Lansoprazole; Naproxen?

  • alcohol
  • alendronate
  • ampicillin
  • aspirin and aspirin-like medicines
  • cidofovir
  • cyclosporine
  • delavirdine
  • digoxin
  • entecavir
  • fluvoxamine
  • gefitinib
  • herbal products that contain feverfew, garlic, ginger, or ginkgo biloba
  • iron salts
  • itraconazole
  • ketoconazole
  • lithium
  • medicines for high blood pressure
  • medicines that affect platelets
  • medicines that treat or prevent blood clots such as warfarin and other 'blood thinners'
  • methotrexate
  • other anti-inflammatory drugs (such as ibuprofen, naproxen or prednisone)
  • pemetrexed
  • sucralfate
  • theophylline
  • voriconazole
  • water pills (diuretics)

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from receiving Lansoprazole; Naproxen?

Side effects that you should report to your prescriber or health care professional as soon as possible:

  • signs of bleeding - bruising, pinpoint red spots on the skin, black tarry stools, blood in the urine, unusual tiredness or weakness, vomiting blood or vomit that looks like coffee grounds
  • signs of an allergic reaction - difficulty breathing or wheezing, skin rash, redness, blistering or peeling skin, hives, or itching, swelling of eyelids, throat, lips
  • blurred vision
  • change in the amount of urine passed
  • difficulty swallowing, severe heartburn or burning, pain in throat
  • fever
  • pain or difficulty passing urine
  • stomach pain, cramps, or vomiting
  • ringing sound in your ears or hearing loss
  • swelling of feet or ankles
  • yellowing of eyes or skin

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • diarrhea or constipation
  • dizziness
  • drowsiness
  • headache
  • nausea

What should I watch for while taking Lansoprazole; Naproxen?

Do not smoke cigarettes or drink alcohol; these increase irritation of your stomach and can make your stomach more susceptible to damage from naproxen.

Let your prescriber or health care professional know if you develop stomach or throat pain. Do not take lansoprazole; naproxen with other pain-killers without advice. Naproxen is available over-the-counter without a prescription. Do not take any prescription or over-the-counter product without talking to your health care professional.

To reduce unpleasant effects on your throat and stomach, do not take lansoprazole; naproxen just before lying down. If you notice black, tarry stools or experience severe stomach pain and vomit blood or what looks like coffee grounds, notify your health care prescriber immediately.

If you are taking medicines that affect the clotting of your blood, such as aspirin or blood thinners such as Coumadin®, talk to your health care provider or prescriber before taking this medicine.

You may get dizzy or sleepy. Do not drive, use machinery, or do anything that needs mental alertness until you know how lansoprazole; naproxen affects you. Stand or sit up slowly, this reduces the risk of dizzy or fainting spells. These effects may be worse if you are an older patient.

It is especially important not to use lansoprazole; naproxen during the last 3 months of pregnancy unless specifically directed to do so by your health care provider. Problems in the unborn child or complications during delivery could occur.

If you are going to have surgery or dental work, tell your prescriber or health care professional that you are taking lansoprazole; naproxen. Brush and floss your teeth and gums gently.

Where can I keep my medicine?

Keep out of the reach of children in the original container.

Store at room temperature between 15 and 30 °C (59 and 86 °F). Protect from light and moisture. Throw away any unused medicine after the expiration date.

(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

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