Known interactions

A-Spas S/L, Adapin, Agnus Castus, Alamag, Alamag Suspension, Aldomet, Aldomet Suspension, Alenic Alka, Almora, Alprazolam Intensol, Alprazolam Oral Solution, Alprazolam tablets, AlternaGEL, AlternaGEL Liquid, Alu-Cap, Alu-Tab, Aludrox, Aluminum and Magnesium Hydroxide, Aluminum and Magnesium Hydroxide Oral Suspension, Aluminum Hydroxide, Aluminum Hydroxide and Magnesium Trisilicate, Aluminum Hydroxide Oral Liquid, Aluminum Hydroxide, Magnesium Carbonate Chewables, Aluminum Hydroxide, Magnesium Carbonate Oral Suspension, Aluminum Hydroxide, Magnesium Hydroxide, and Simethicone, Aluminum Hydroxide, Magnesium Hydroxide, and Simethicone oral suspension, Amitriptyline, Amitriptyline Injection, Amoxapine, Amphojel, Amphojel Suspension, Anaspaz, Antispas Injection, Antispasmodic Elixer, Artane, Artane Elixir, Artane Sequels, Asendin, Ativan, Ativan Injection, AtroPen, Atropine Auto-Injection, Atropine Care, Atropine Injection, Atropine Ophthalmic, Atropine Oral, Atropine, Hyoscyamine, Phenobarbital, and Scopolamine Oral, Atropine, Hyoscyamine, Phenobarbital, and Scopolamine Elixir, Atropisol, Aventyl, Aventyl Oral Solution, Awa, Ballota, Ballota nigra, Bellacane SR, Belladonna Alkaloids, Ergotamine, and Phenobarbital Tablets, Bellaspas, Bellergal-S, Bentyl, Bentyl Injection, Bentyl Syrup, Benztropine Mesylate Injection, Benztropine Mesylate Oral, Black Horehound, Black Stinking Horehound, Byclomine, Catapres, Catapres-TTS, Chaste Tree, Chasteberry, Chlordiazepoxide, Chlordiazepoxide and Clidinium Bromide, Chlordiazepoxide Injection, Chlorpromazine, Chlorpromazine Concentrate or Syrup, Chlorpromazine Extended-Release Capsules, Chlorpromazine Injection, Chlorpromazine Intensol Concentrate, Chlorpromazine Suppositories, Cloister Pepper, Clonazepam, Clonazepam Orally Disintegrating Tablets, Clonidine, Clonidine injection, Clonidine Patch, Clorazepate, Co Q 10, Coenzyme Q-10, Cogentin, Cogentin Injection, Cognex, Compazine, Compazine Injection, Compazine Rectal Suppositories, Compazine Spansules, Compazine Syrup, Cystospaz, Cystospaz-M, Dalmane, Desipramine, Di-Gel, Di-Spaz, Di-Spaz Injection, Dialume, Diastat, Diazepam, Diazepam Injection, Diazepam Intensol, Diazepam Oral Solution, Diazepam Rectal Gel, Dibent Injection, Dicyclomine, Dicyclomine Injection, Dicyclomine Syrup, Dilantin, Dilantin Infatab, Dilantin Injection, Dilantin Kapseals, Dilantin-125, Dilomine Injection, Ditropan, Ditropan Syrup, Donnamar, Donnatal, Donnatal Elixir, Doxepin, Doxepin Oral Solution, Doxepin Topical, Duraclon injection, ED-SPAZ, Elavil, Elavil Injection, Endep, Ethotoin, Etrafon, Fe-Tinic, Ferrex 150, Fluphenazine, Fluphenazine Injection, Fluphenazine Oral Concentrate or Elixir, Flurazepam, Folergot-DF, Furazolidone, Furazolindone Oral Suspension, Furoxone, Furoxone Oral Suspension, Gastrosed, Gaviscon, Gaviscon Chewable, Gaviscon Chewable Tablets, Glycopyrrolate, Glycopyrrolate Injection, Halcion, Haldol Decanoate Injection, Haldol Injection, Haldol Oral Concentrate, Haldol Tablets, Haloperidol Decanoate Injection, Haloperidol Lactate Injection, Haloperidol Oral Concentrate, Haloperidol Tablets, Hyoscyamine, Hyoscyamine Injection, Hyoscyamine Liquid, Hyoscyamine Sublingual Tablets, Hyoscyamine sustained-release, Hyosophen Elixer, Imipramine, Imipramine HCl, Imipramine Pamoate, Iosopan, Isopto Atropine, Isopto Hyoscine, Kava, Kava-Kava, Kawa, Kew, Klonopin, Klonopin Wafer, Levsin, Levsin /SL, Levsin Elixir, Levsin Injection, Levsinex Timecaps, Librax, Libritabs, Librium, Librium Injection, Lorazepam, Lorazepam Injection, Lorazepam Intensol, Lorazepam Oral Solution, Maalox, Maalox Suspension, Mag-Ox, Magaldrate, Magnalox, Magnalox Suspension, Magnesium Gluconate, Magnesium Hydroxide, Magnesium Hydroxide Chewable Tablets, Magnesium Oxide, Magnesium Sulfate Injection, Magnox Suspension, Magonate, Magtrate, Maox, Meperidine and Promethazine Oral, Meprozine, Mesoridazine Injection, Mesoridazine Oral, Mesoridazine Oral Concentrate, Methscopolamine, Methyldopa, Methyldopa Injection, Methyldopa Oral Suspension, Milk of Magnesia, Milk of Magnesia-Concentrated, Mintox Suspension, Mitoquinone, Monk's Berry, Monk's Pepper, Mylanta, Mylanta Oral Suspension, Mylanta tablets, Nardil, Navane, Navane Concentrate, Navane Injection, Neosol, Nestrex, Niferex, Niferex 150, Niravam, Norflex, Norflex Injection, Norpramin, Nortriptyline, Nortriptyline Oral Solution, Nu-Iron, Nu-Iron-150, Or-Tyl Injection, Orphenadrine, Orphenadrine Injection, Oxazepam, Oxybutynin, Oxybutynin Oral Syrup, Oxybutynin Patch, Oxytrol, Pamelor, Pamine, Papaverine, Papaverine Injection, Parnate, Pavabid, Pavaged TD, Peganone, Permitil, Permitil Oral Concentrate, Perphenazine and Amitriptyline, Perphenazine Injection, Perphenazine Oral, Perphenazine Oral Concentrate, Phenelzine, Phenerbel-S, Phenergan, Phenergan and Codeine, Phenergan DM, Phenergan Injection, Phenergan Rectal Suppositories, Phenergan Syrup, Phenergan VC, Phenergan VC with Codeine, Phenylephrine, Promethazine and Codeine, Phenytek, Phenytoin, Phenytoin Chewable, Phenytoin Injection, Phenytoin Oral Suspension, Pherazine VC, Phillips Milk of Magnesia, Phillips' Chewable, Piper methysticum, Polysaccharide Iron Complex, Polysaccharide Iron Complex Elixir, Pro-Banthine, Prochlorperazine, Prochlorperazine ER, Prochlorperazine Injection, Prochlorperazine Oral Syrup, Prochlorperazine Rectal Suppositories, Prolixin, Prolixin Decanoate, Prolixin Elixir, Prolixin Enanthate, Prolixin Injection, Prolixin Oral Concentrate, Prometh and Codeine, Prometh VC Plain, Prometh with Dextromethorphan, Promethazine and Codeine, Promethazine and Dextromethorphan, Promethazine and Phenylephrine, Promethazine DM, Promethazine Injection, Promethazine Oral, Promethazine Oral Syrup, Promethazine Rectal Suppositories, Promethazine VC with Codeine, Promethegan, Propantheline, Protriptyline, Pyridoxine, Pyridoxine Injection, Q 10, Restoril, Riopan, Robinul, Robinul Forte, Robinul Injection, Rulox, Sal-Tropine, Scopace, Scopolamine Injection, Scopolamine Ophthalmic, Scopolamine Patch, Scopolamine Tablets, Serax, Serentil, Serentil Injection, Serentil Oral Concetrate, Sinequan, Sinequan Oral Solution, Sonazine Concentrate, Sonazine Syrup, Spasmoject Injection, Spastrin, Surmontil, Symax, Symax Duotabs, Symax SR, Symax-SL, Symax-SR, Tacrine, Temazepam, Thiethylperazine Injection, Thiethylperazine Oral, Thiethylperazine Suppositories, Thiothixene Capsules, Thiothixene Injection, Thiothixene Oral Concentrate, Thor-Prom, Thorazine, Thorazine Concentrate, Thorazine Injection, Thorazine Spansule, Thorazine Suppositories, Thorazine Syrup, Tofranil, Tofranil PM, Tonga, Torecan Injection, Torecan Oral, Transderm-Scop, Transdermal scopolamine, Tranxene, Tranxene T, Tranxene-SD, Tranylcypromine, Triavil, Triazolam, Trihexane, Trihexy, Trihexy-2, Trihexy-5, Trihexyphenidyl, Trihexyphenidyl Elixir, Trilafon, Trilafon Concentrate, Trilafon Injection, Trimipramine, Ubidecarenone, Ubiquinone, Uro-Mag, Valium, Valium Injection, Vanatrip, Vanatrip Injection, Vitamin B6, Vitamin Q, Vitex, Vitex agnus-castus, Vivactil, Xanax, Yagona, Zonalon Cream.

Description of Larodopa

Brand Name(s): Dopar, Larodopa

Generic Name Levodopa

What are levodopa tablets?

LEVODOPA (Larodopa®) is used to treat Parkinson's disease. Levodopa can help correct an imbalance of chemicals in the brain caused by Parkinson's disease. Levodopa will not cure Parkinson's disease, but will help to control the symptoms. Generic levodopa tablets are not available.

What should my health care professional know before I take levodopa?

They need to know if you have any of these conditions:

  • asthma or lung disease
  • depression or other mental illness
  • diabetes
  • glaucoma
  • heart disease, including history of a heart attack
  • irregular heart beat
  • kidney disease
  • liver disease
  • melanoma or suspicious skin lesions
  • seizure disorder
  • stomach or intestinal ulcers
  • an unusual or allergic reaction to levodopa, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I take this medicine?

Take levodopa tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a glass of water. It is best to take levodopa on an empty stomach, either 30 minutes before you eat or 1 hour after you eat. If the medicine upsets your stomach, you can take it with a cracker or fruit. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine without talking with your health care provider.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is less than 2 hours to your next dose, take only that dose. Do not take double or extra doses. Try not to miss a dose; it is important to keep your regular dosing schedule.

What drug(s) may interact with levodopa?

  • cocaine
  • droperidol
  • furazolidone
  • isoniazid, INH
  • iron supplements
  • kava kava
  • linezolid
  • medicines for high blood pressure
  • medicines for depression, avoid those called MAO inhibitors-phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®)
  • medicines for mental problems and psychotic disturbances
  • metoclopramide
  • papaverine
  • phenytoin
  • procarbazine
  • s-adenosyl-l-methionine, SAM-e
  • vitamin B6(pyridoxine) supplements
  • water pills

Tell your prescriber or health care professional about all other medicines that you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from taking levodopa?

Side effects that you should report to your prescriber or health care professional as soon as possible:

  • difficulty passing urine
  • dizziness, lightheadedness, or fainting spells
  • fast or irregular heartbeat (palpitations)
  • mental depression
  • mood changes such as aggressive behavior or hallucinations
  • stomach pain
  • uncontrolled movements of the mouth, head, hands, feet, shoulders, eyelids or other unusual muscle movements

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • anxiety, confusion, or nervousness
  • dark color (brown, red, or black) of saliva, urine or sweat
  • headache
  • loss of appetite
  • muscle twitches
  • nausea/vomiting
  • nightmares, trouble sleeping
  • unusual tiredness or weakness

What should I watch for while taking levodopa?

Visit your prescriber or health care professional for regular checks on your progress. It may be several weeks or months before you feel the full benefits of levodopa. Continue to take your medicine on a regular schedule and do not stop taking except on your prescriber's advice. Do not take any additional medicines for Parkinson's disease without first consulting with your health care provider.

You may experience a "wearing off" effect prior to the time for your next dose of levodopa. You may also experience an "on-off" effect where the medicine apparently stops working for anything from a minute to several hours, then suddenly starts working again. Tell your prescriber or health care professional if any of these symptoms happen to you, he/she may need to adjust your dosage.

A high-protein diet can slow or prevent absorption of levodopa. Avoid high protein foods near the time of taking levodopa to help to prevent these problems. Take levodopa at least 30 minutes before eating or one hour after meals. You may want to eat higher protein foods later in the day or in small amounts. Discuss your diet with your prescriber or health care professional or nutritionist.

Do not take iron supplements within 2 hours of taking levodopa. The iron may decrease the amount of levodopa in your system and decrease the effectiveness of the drug.

Do not sit or stand up quickly. This reduces the risk of dizzy or fainting spells. The dizziness should decrease after taking levodopa for a couple of days. Alcohol can increase possible dizziness; avoid alcoholic drinks.

If you are going to have surgery, tell your prescriber or health care professional that you are taking levodopa.

If you are diabetic, levodopa may interfere with the accuracy of some tests for sugar or ketones in the urine (does not interfere with blood tests). Check with your prescriber or health care professional before changing the dose of your diabetic medicine.

Levodopa may discolor the urine or sweat, making it look darker or red in color; this is of no cause for concern. However, this may stain clothing or fabrics.

Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open.

Store at room temperature between 15 and 30 °C (59 and 86 °F). Protect from light. Keep container tightly closed. Throw away any unused medicine after the expiration date.

(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

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