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Known interactions

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Info about Laronidase

Brand Name(s): Aldurazyme

Generic Name Laronidase

What is laronidase injection?

LARONIDASE (Aldurazyme®) is a drug that replaces an enzyme you may be missing in your body if you have mucopolysaccharidosis I (MPS I). Laronidase is similar to a natural substance in the body called alpha-L-iduronidase. Laronidase helps your body to break down certain products that may lead to damage in your tissues or organs. This drug is not a cure, but may help you breathe easier and have more endurance. Generic laronidase injections are not yet available.

What should my health care professional know before I receive laronidase?

They need to know if you have any of these conditions:

  • an unusual reaction to laronidase, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should this medicine be used?

Laronidase injection will be given to you by a health care professional in a clinic or hospital, or it might be given by home health care. It is a solution that is injected into your veins (infused) over 3 or 4 hours, and your health care provider will give you any special instructions. You may be asked to take some medications, such as an antihistamine (for example, Benadryl®) and a medicine to help prevent fever (such as Tylenol® or Motrin®) one hour before your infusion begins. It is important that you take these medications as directed.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed. Laronidase is usually used in children 5 years of age or older.

What if I miss a dose?

A health care professional will administer your dose, usually once a week. Try not to miss your appointment. Let your health care provider know if you will miss your weekly dose, and follow any instructions they give regarding the missed dose.

What drug(s) may interact with laronidase?

There are no known drug interactions with laronidase.

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from receiving laronidase?

Side effects that you should report to your prescriber or health care professional as soon as possible:

  • chest pain
  • difficulty breathing, shortness of breath, swelling or tightening of your throat
  • dizziness or fainting
  • fever
  • fluid retention or swelling of your hands, feet or face
  • redness, pain or swelling at your injection site
  • skin rash, hives or itching
  • yellowing of skin or whites of your eyes

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • headache
  • flushing

What should I watch for while taking laronidase?

Before you receive the laronidase, be sure to tell your health care provider if you have previously had any type of allergic reaction to laronidase, such as hives, swelling in your throat, difficult breathing, shortness of breath, a skin reaction or severe itching. Also let your health care provider know if you have also experienced fainting, dizziness or weakness.

Tell your provider if you notice any red streaks, swelling or warmth to the touch in the area around your injection site (where the needle went into your vein). Call your provider if you develop a fever.

Where can I keep my medicine?

You will probably receive your infusions at a clinic or hospital and will not need to store laronidase at home. If you will receive laronidase at home, your health care provider will give you specific instructions on storage. It must be refrigerated; do not freeze or leave at room temperature.


(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

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