Known interactions

Acetaminophen and Butalbital, Alamag, Alamag Suspension, Alder Buckthorn, Alder Dogwood, Alenic Alka, Almora, Aloe barbadensis, Aloe species, Aloe vera, AlternaGEL, AlternaGEL Liquid, Alu-Cap, Alu-Tab, Aludrox, Aluminum and Magnesium Hydroxide Oral Suspension, Aluminum and Magnesium Hydroxide, Aluminum Hydroxide, Aluminum Hydroxide and Magnesium Trisilicate, Aluminum Hydroxide Oral Liquid, Aluminum Hydroxide, Magnesium Carbonate Chewables, Aluminum Hydroxide, Magnesium Carbonate Oral Suspension, Aluminum Hydroxide, Magnesium Hydroxide, and Simethicone, Aluminum Hydroxide, Magnesium Hydroxide, and Simethicone oral suspension, Amigesic, Amobarbital, Amphojel, Amphojel Suspension, Amytal, Antispasmodic Elixer, Argesic-SA, Arrow Wood, Artha-G, Arthropan, Aspirin and Carisoprodol, Aspirin, Caffeine and Dihydrocodeine, Atropine, Hyoscyamine, Phenobarbital, and Scopolamine Elixir, Atropine, Hyoscyamine, Phenobarbital, and Scopolamine Oral, Axocet, Bellacane SR, Belladonna Alkaloids, Ergotamine, and Phenobarbital Tablets, Bellaspas, Bellergal-S, Biaxin, Biaxin Suspension, Biaxin XL, Bismatrol, Bismatrol Extra Strength, Bismatrol Oral Liquid, Bismuth Subsalicylate, Bismuth Subsalicylate Oral Liquid, Bismuth Subsalicylate, Metronidazole, and Tetracycline Combination, Bitter Bark, Black Dogwood, Bottle-brush, Breezee Mist Antifungal, Bucet, Buffered Aspirin and Pravastatin, Bupap, Burn Plant, Butabarbital, Butabarbital Oral Elixir, Butex Forte, Butisol, Butisol Elixir, Caffeine, Aspirin and Dihydrocodeine, California Buckthorn, Cape Aloe, Cardizem, Cardizem CD, Cardizem Injection, Cardizem LA, Cardizem SR, Carisoprodol Compound, Cartia XT, Cascara, Cephadyn, Cerebyx, Children's Kaopectate, Chittem Bark, Choline Magnesium Trisalicylate, Choline Salicylate and Magnesium Salicylate Solution, Choline Salicylate oral solution, Chroma-Pak injection, Chromic Chloride injection, Chromium, Chromium 3, Chromium Acetate, Chromium Chloride, Chromium chloride injection, Chromium 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Quick guide to M-Prednisol

Brand Name(s): Depo-Medrol, Depoject, Depopred, Duralone, M-Prednisol, Medralone, Solu-Medrol, depMedalone

Generic Name Methylprednisolone Injection

What is methylprednisolone injection?

METHYLPREDNISOLONE (Depo-Medrol®, Solu-Medrol®) is a corticosteroid. There are two forms of injection. The ready-prepared suspension is for relief of swelling, inflammation, redness, itching, and allergic skin conditions. The injection prepared from a sterile powder is for replacement therapy in adrenocortical insufficiency and also for the treatment of multiple sclerosis. Generic methylprednisolone injections and injectable suspensions are available.

What should my health care professional know before I receive methylprednisolone?

They need to know if you have any of these conditions:

  • cataracts or glaucoma
  • Cushing's syndrome
  • heart problems, or previous heart attack
  • high blood pressure or blood clotting disorder
  • infection, such as herpes, measles, tuberculosis or chickenpox
  • myasthenia gravis
  • psychosis
  • osteoporosis
  • recent surgery
  • seizures (convulsions)
  • stomach or intestinal disease, including colitis
  • under-active thyroid
  • an unusual or allergic reaction to methylprednisolone, other corticosteroids, medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Methylprednisolone (Solu-Medrol®) is for injection into a muscle or into a vein. Methylprednisolone (Depo-Medrol®) suspension is for injection into a joint, lesion, or soft tissue. Injections are given by a health-care professional in a hospital, clinic, or prescriber's office.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

This may not apply. If you are having a series of injections over a prolonged period, try not to miss an appointment. Call your prescriber or health care professional to reschedule if you are unable to keep an appointment.

What drug(s) may interact with methylprednisolone?

  • acetazolamide
  • antiinflammatory drugs (NSAIDs, such as ibuprofen)
  • barbiturate medicines for inducing sleep or treating seizures
  • bosentan
  • certain heart medicines
  • erythromycin
  • female hormones, including contraceptives or birth control pills
  • itraconazole
  • live virus vaccines, and other toxoids and vaccines
  • medicines for diabetes
  • phenytoin
  • rifabutin
  • rifampin
  • troleandomycin
  • voriconazole
  • water pills
  • warfarin

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from receiving methylprednisolone?

Side effects that you should report to your prescriber or health care professional as soon as possible:

  • bloody or black, tarry stools
  • confusion, excitement, restlessness, a false sense of well-being
  • eye pain, decreased or blurred vision, or bulging eyes
  • fever, sore throat, sneezing, cough, or other signs of infection, wounds that will not heal
  • frequent passing of urine
  • increased thirst
  • irregular heartbeat
  • menstrual problems
  • mental depression, mood swings, mistaken feelings of self-importance or of being mistreated
  • muscle cramps or weakness
  • nausea, vomiting
  • pain in hips, back, ribs, arms, shoulders, or legs
  • pain, redness, swelling, or infection at the injection site
  • rounding out of face
  • skin problems, acne, thin and shiny skin
  • stomach pain
  • swelling of feet or lower legs
  • unusual bruising, pinpoint red spots on the skin
  • unusual tiredness or weakness
  • weight gain or weight loss

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • diarrhea or constipation
  • headache
  • increased or decreased appetite
  • increased sweating
  • nervousness, restlessness, or difficulty sleeping
  • upset stomach
  • unusual increased growth of hair on the face or body

What should I watch for while taking methylprednisolone?

Visit your prescriber or health care professional for regular checks on your progress. If you are receiving methylprednisolone over a prolonged period, carry an identification card with your name and address, the type and dose of your medicine, and your prescriber's name and address.

If you are receiving methylprednisolone regularly, avoid contact with people who have an infection. You will have an increased risk from infection while receiving methylprednisolone. Tell your prescriber or health care professional if you are exposed to anyone with measles or chickenpox, or if you develop sores or blisters that do not heal properly.

People who are taking certain dosages of methylprednisolone may need to avoid immunization with certain vaccines or may need to have changes in their vaccination schedules to ensure adequate protection from certain diseases. Make sure to tell your prescriber or health care professional that you are taking methylprednisolone before receiving any vaccine.

If you are going to have surgery, tell your prescriber or health care professional that you have received methylprednisolone within the last twelve months.

If you receive methylprednisolone every day, you may need to watch your diet. Your body can lose potassium while you are taking this medicine. Ask your prescriber or health care professional about your diet.

Methylprednisolone can affect your blood sugar. If you are diabetic check with your prescriber or health care professional if you need help adjusting the dose of your diabetic medicine.

Alcohol can increase the risk of getting serious side effects while you are taking methylprednisolone. Avoid alcoholic drinks.

Methylprednisolone can interfere with certain lab tests and can cause false skin test results.

If methylprednisolone has been injected into one of your joints, do not put too much stress on the joint. Talk to your prescriber or health care professional about how much you can use the joint while it is healing.

Where can I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 °C (59 and 86 °F); do not freeze. Throw away any unused medicine after the expiration date. Throw away injection solutions prepared from sterile powder within 48 hours.

(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

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