Known interactions

Amerge, Aquatab C Tablets, Aquatab DM, Bellacane SR, Belladonna Alkaloids, Ergotamine, and Phenobarbital Tablets, Bellaspas, Bellergal-S, Benylin, Benylin Expectorant Liquid, Cafatine PB, Cafatine Suppositories, Cafergot, Cafergot Suppositories, Cafetrate Suppositories, Carbex, Celexa, Celexa Solution, Cheracol D Cough Liquid, Children's Formula Cough Syrup, Citalopram, Citalopram Oral Solution, Citalopram orally-disintegrating tablets, Clear Tussin 30 Liquid, Cold & Cough Tussin Softgels, citalopram orally-disintegrating tablets, D.H.E. 45 Injection, Delsym, Demerol Injection, Demerol Oral, Demerol Syrup, Dextromethorphan, Dextromethorphan, Guaifenesin, and Potassium Guaiacolsulfonate, Diabetic Tussin DM Liquid, Dihydroergotamine Injection, Dihydroergotamine Nasal Spray, Effexor, Eldepryl, Ercaf, Ergo-Caff, Ergomar, Ergotamine and Caffeine Rectal Suppositories, Ergotamine Sublingual Tablets, Ergotamine Tartrate and Caffeine, Escitalopram, Escitalopram Oral Solution, Eskalith, Eskalith CR, Extra Action Cough Syrup, Fenesin DM Tablets, Fluoxetine and Olanzapine, Fluoxetine capsules (Sarafem), Fluoxetine Oral Solution, Fluoxetine tablets or capsules, Fluvoxamine, Folergot-DF, fluoxetine delayed-release capsules, Genatuss DM Syrup, Guaifenesin and Dextromethorphan, Guaifenesin and Dextromethorphan Oral Solution, Guaifenex DM Tablets, Guiatuss CF Syrup, Guiatuss DM Syrup, Guiatussin with Dextromethorphan Liquid, Halotussin DM Sugar Free Syrup, Halotussin DM Syrup, Humibid DM, Humibid DM Sprinkle Capsules, Humibid DM Tablets, Imitrex, Imitrex Injection, Imitrex Nasal Spray, Iobid DM Tablets, Isocarboxazid, Kolephrin GG/DM Liquid, L-tryptophan, Lexapro, Lexapro Oral Solution, Lithane, Lithium, Lithium Oral Syrup, Lithium, Extended-Release, Lithobid, Lithonate, Lithotabs, Luvox, Marplan, Maxalt, Maxalt MLT, Maxifed DM Tablets, Medent-DM Tablets, Meperidine and Promethazine Oral, Meperidine Hydrochloride Injection, Meperidine Oral, Meperidine Syrup, Meprozine, Methysergide, Migergot, Migranal, Muco-Fen-DMT Tablets, Mytussin DM Liquid, Naldecon Senior DX Liquid, Naratriptan, Nardil, Nefazodone, PanMist-DM Tablets, Panmist-DM Syrup, Parnate, Paroxetine, Paroxetine Oral Suspension, Paxil, Paxil CR, Paxil Suspension, Pertussin, Phanatuss DM Syrup, Phenadex Senior Liquid, Phenelzine, Phenerbel-S, Phenergan DM, Profen Forte DM Tablets, Profen II DM Liquid, Profen II DM Tablets, Prometh with Dextromethorphan, Promethazine and Dextromethorphan, Promethazine DM, Protuss DM Tablets, Prozac, Prozac Oral Solution, Prozac Weekly, Pseudoephedrine, Guaifenesin and Dextromethorphan, Pseudoephedrine, Guaifenesin, Dextromethhorphan Liquid, Pseudovent DM, Respa-DM Tablets, Rhinosyn-DMX Syrup, Rizatriptan, Rizatriptan Disintegrating Tablets, Robafen CF Syrup, Robafen DM Syrup, Robitussin CF Syrup, Robitussin Cough, Robitussin DM Syrup, Safe Tussin 30 Liquid, Sansert, Sarafem, Scot-Tussin Senior Clear Liquid, Selegiline, Sertraline, Sertraline Oral Solution, Serzone, Silexin, Siltussin DM Syrup, Spastrin, Sudal-DM, Sumatriptan Injection, Sumatriptan Nasal Spray, Sumatriptan Oral, Symbyax, Tolu-Sed DM Syrup, Touro CC Tablets, Touro DM, Tranylcypromine, Tryptophan, Tuss-DM, Venlafaxine, Vicks 44E Liquid, Vicks Pediatric Forumula 44E Liquid, Wigraine, Wigraine Suppositories, Z-Cof DM Syrup, Zolmitriptan, Zolmitriptan Disintegrating Tablet, Zolmitriptan Nasal Spray, Zoloft, Zoloft Oral Solution, Zomig, Zomig Nasal Spray, Zomig ZMT.

On-line Meridia

Brand Name(s): Meridia

Generic Name Sibutramine

What are sibutramine capsules?

SIBUTRAMINE (Meridia®) is used to control hunger in patients who are overweight. Sibutramine is prescribed along with a reduced-calorie diet and, if appropriate, an exercise program. Do not share this medicine with anyone else. Generic sibutramine capsules are not yet available.

What should my health care professional know before I take sibutramine?

They need to know if you have or have had any of these conditions:

  • anorexia nervosa, bulimia or other eating disorder
  • bleeding disorder
  • depression or other mood disorder
  • gallstones
  • glaucoma
  • heart disease, such as congestive heart failure or a previous heart attack
  • heart rhythm problems or palpitations, chest pain
  • high blood pressure
  • kidney disease
  • liver disease
  • lung disease
  • migraine headaches
  • osteoporosis
  • Parkinson's disease
  • previous use of other weight loss drugs
  • sleeplessness
  • seizures (epilepsy or convulsions)
  • stroke or symptoms of a stroke (i.e., transient ischemic attacks or TIAs)
  • thyroid disease
  • an unusual or allergic reaction to sibutramine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I take this medicine?

Take sibutramine capsules by mouth. Follow the directions on the prescription label. Swallow with a drink of water. You may take this medicine with meals or food. Do not take your medicine more often than directed. Do not stop taking except on your prescriber's advice.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What drug(s) may interact with sibutramine?

Do not take sibutramine with the following medications:

  • medicines called MAO Inhibitors-phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®), selegiline (Eldepryl®)
  • other medicines for weight loss, including herbal and nonprescription weight-loss drugs, like Ma huang or ephedra
  • some medicines for migraines (such as dihydroergotamine, ergotamine, eletriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan)
  • tryptophan

Sibutramine may also interact with:

  • bosentan
  • bupropion
  • dextromethorphan
  • fentanyl
  • grapefruit juice
  • ketoconazole
  • linezolid
  • lithium
  • medicines for high blood pressure
  • medicines for allergy, cold or flu symptoms (decongestants, cough suppressants)
  • medicines for anxiety, depression or other mental problems
  • meperidine
  • procarbazine
  • St. John's wort
  • voriconazole

Tell your prescriber or other health care provider about all other medicines you are taking, including non-prescription medicines and illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from taking sibutramine?

Side effects that you should report to your prescriber or health care professional as soon as possible:

Rare or uncommon:

  • bleeding, easy bruising, nose bleeds, bleeding of gums
  • chest pain
  • difficulty breathing
  • fever
  • heart palpitations
  • seizures
  • severe dizziness

Stop using sibutramine and call your prescriber or health care professional as soon as possible if you experience any of these side effects.

More common:

  • increased heart rate
  • increased blood pressure
  • menstrual problems
  • muscle or joint pain
  • pain, burning or tingling in the hands or feet
  • unusual swelling of the arms or legs
  • unusual tiredness or weakness
  • visual problems

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • agitation or irritability
  • anxiety
  • back pain
  • constipation
  • diarrhea
  • difficulty sleeping
  • dizziness
  • drowsiness
  • dry mouth
  • gas
  • headache
  • nausea or vomiting
  • skin problems
  • stomach problems
  • sweating
  • taste disturbance
  • throat irritation or pain

What should I watch for while taking sibutramine?

Visit your prescriber regularly to have your blood pressure and heart rate checked. Contact your prescriber if you think you are experiencing any unusual side effects.

Keep in mind that sibutramine was intended to be used in addition to a healthy diet and appropriate exercise. The best results are achieved this way. Do not increase or in any way change your dose without consulting your prescriber.

A weight-loss of 4 pounds or more during your first month of treatment is a good indicator of success with sibutramine. Most of the weight you will lose will be lost gradually during 6—12 months. Many people who lose weight and remain on sibutramine therapy maintain their weight loss.

You should not use herbal or over-the-counter weight-loss products while taking sibutramine. Non-drug nutritional supplements, like vitamins, minerals, and proteins or amino acids (with the exception of tryptophan), can be used with sibutramine. You should make sure your prescriber knows what nutritional supplements you are taking and why you are taking them.

Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open.

Store at controlled room temperature 15 and 30 °C (59 and 86 °F). Keep container tightly closed. Protect capsules from heat, light and moisture. Throw away any unused medicine after the expiration date.

(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

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