русский

Known interactions

2-Amino-2-Deoxyglucose, Acanthopanax senticosus, Acarbose, Accupril, Acebutolol, Aceon, Acetazolamide, Acetazolamide Injection, Acetazolamide Sustained-Release, Acetohexamide, Ackerkraut, Actoplus Met, Actos, Adalat, Adalat CC, Afeditab CR, Agathosma betulina, Agoral Liquid, Agrimonia, Agrimonia eupatoria, Agrimony, Airelle, AK-Zol, Alant, Aldactazide, Aldactone, Alder Buckthorn, Alder Dogwood, Alfalfa, Alhova, All Heal, Allium, Allium sativum, Aloe barbadensis, Aloe species, Aloe vera, Altace, Amaryl, American Ginseng, Amiloride and Hydrochlorothiazide, Amlodipine, Amlodipine and Atorvastatin, Amorphophallus konjac, Anchi, Apidra, Aquatensen, Arrow Wood, Asclepias tuberosa, Asian Ginseng, Atacand, Atenolol, Atenolol and Chlorthalidone, Atenolol Injection, Avandamet, Avandia, Avapro, Azucacaa, Baikal Scullcap, Baikal Skullcap Root, Bal, Barley, Barley Grass, Barosma betulina, Basket Willow, Bdellium, Benazepril and Hydrochlorothiazide, Benicar, Benicar HCT, Bepridil, Betapace, Betapace AF, Betaxolol Ophthalmic, Betaxolol Oral, Betimol, Betoptic, Betoptic S, Bilberry, Bird Lime, Bird's Foot, Bisoprolol, Bitter Bark, Black Dogwood, Black ginger, Black Psyllium, Black-Draught, Blocadren, Blond Psyllium, Blowball, Bol, Bramhi, Brevibloc, Bucco, Buchu, Buku, Bumetanide, Bumetanide Injection, Bumex, Bumex Injection, Burn Plant, Butterfly Weed, Caduet, Calan, Calan SR, California Buckthorn, Canada Root, Canadian Ginseng, Candesartan, Canker Wort, Canton ginger, Cape Aloe, Capim Doce, Capoten, Captopril, Cardene, Cardene IV, Cardizem, Cardizem CD, Cardizem Injection, Cardizem LA, Cardizem SR, Carteolol, Carteolol Ophthalmic, Cartia XT, Cartrol, Carvedilol, Cascara, Cassia acutifolia, Cassia angustifolia, Cassia senna, Centella asiatica, Chinese Ginseng, Chitosamine, Chittem Bark, Chlorothiazide, Chlorothiazide Injection, Chlorothiazide Suspension, Chlorpropamide, Chlorthalidone, Chroma-Pak injection, Chromic Chloride injection, Chromium, Chromium 3, Chromium Acetate, Chromium Chloride, Chromium chloride injection, Chromium injection, Chromium Picolinate, Church Steeples, Ci Wu Jia, Co Q 10, Cochin ginger, Cocklebur, Coenzyme Q-10, Commiphora molmol, Commiphora myrrha, Common Buckthorn, Common ginger, Coreg, Corgard, Corzide, Cosopt, Covera-HS, Cozaar, Crack Willow, Crataegus laevigata, Crataegus monogyna, Crataegus oxyacantha, Curcuma, Curcuma species, Daidzein, Damiana, Dandelion, Demadex Injection, Demadex Oral, Devil's Bush, Devil's Claw, Devil's Fuge, Devil's Leaf, Devil's Tongue, Diabeta, Diabinese, Diamox, Diamox Injection, Diamox Sequels, Dilacor XR, Diltia XT, Diltiazem, Diltiazem ER, Diltiazem Injection, Diosma, Diovan, Diurigen, Diuril, Diuril Injection, Diuril Suspension, Docusate and Senna, Dog Wood, Dorzolamide and Timolol Ophthalmic, Dyazide, Dyeberry, Dymelor, DynaCirc, DynaCirc CR, Dyrenium, Edecrin, Elecampane, Elephant-foot Yam, Eleuthero, Eleutherococcus senticosus, Elf Dock, Elfwort, Enalapril, Enduron, Enebro, Eprosartan, Erva Doce, Esidrix, Esmolol, Ethacrynic Acid, Eucalyptus, European Blueberry, European Buckthorn, European Mistletoe, Exlax, Exlax Chocolated, Ezide, Felodipine, Fenugreek, Feuille de Luzerna, Five Fingers, Flea Seed, Flux Root, Fortamet, Fosinopril, Frangula Bark, Funffing, Furosemide, Furosemide Injection, Furosemide Oral Solution, Garden ginger, Garlic, Ge Gen, Genevrier, Ginepro, Gingembre, Ginger, Ginkgo, Ginkgo Biloba, Ginseng, American, Ginseng, Panax, GlaucTabs, Glimepiride, Glipizide, Glipizide and Metformin, Glipizide Extended-Release, Glossy Buckthorn, Glucomannan, Glucophage, Glucophage XR, Glucosamine, Glucosamine Hydrochloride, Glucosamine Sulfate, Glucotrol, Glucotrol XL, Glucovance, Glyburide, Glyburide and Metformin, Glynase, Glyset, Golden Bough, Gotu Kola, Grapple Plant, Greek Clover, Greek Hay, Guggal Resin, Guigai, Gum Myrrh, Gurmar, Gymnema sylvestre, Hagedorn, Harpagophytum procumbens, Hartshorn, Haw, Hawthorn, Hedgethorn, Heerabol, Herb de la Croix, Herba de la pastora, Herbe de Saint-Guillaume, Highwaythorn, Hordeum vulgare, Horse-elder, Horseheal, Hu Lu Ba, Huang Qin, Huckleberry, Humalog, Humalog Mix 75/25, Humulin, Humulin 50/50, Humulin 70/30, Hwanggum, Hydrochlorothiazide, Hydrocotyle asiatica, HydroDIURIL, Hygroton, Iletin II, Iletin II Mixed, Imber, Indapamide, Inderal, Inderal IV, Indian Pennywort, Indian Saffron, Insulin - Mixed, Insulin glulisine, Insulin injection, Insulin Lispro, Inula helenium, Irbesartan, Irish Daisy, Isoptin, Isoptin Injection, Isoptin SR, Isphagula, Isradipine, Isradipine Extended-Release Tablets, Jamaican ginger, Japanese Arrowroot, Japanese Ginseng, Japanese Silver Apricot, Juniper, Juniperus communis, Kaa Jhee, Kerlone Oral, Kew Tree, Konjac, Konjac Mannan, Konnyaku, Korean Ginseng, Kudzu, Kuli, Labetalol, Labetalol Injection, Lasix, Lasix Injection, Lasix Oral Solution, Latanoprost; Timolol eye solution, Leonurus cardiaca, Leotodon taraxacum, Levatol, Lignum Crucis, Lion's Ear, Lion's Tail, Lion's Tooth, Lisinopril, Lisinopril and Hydrochlorothiazide, Liverwort, Lopressor, Lopressor HCT, Lopressor Injection, Losartan, Lotensin HCT, Lozol, Lucerne, Mai Ya, Maidenhair Tree, Marsh Penny, Mavik, Maxiumum Relief Exlax, Maxzide, Mayblossom, Maybush, Mayflower, MEL, Medicago, Medicago sativa, Melatonin, Merasingi, Metaglip, Metformin, Metformin Extended-Release, Metformin Oral Solution, Methazolamide, Methi, Methyclothiazide, Metolazone, Metolazone extended-release tablets, Metoprolol and Hydrochlorothiazide, Metoprolol ER, Metoprolol Injection, Metoprolol Oral, Mexican damiana, Micardis, Micronase, Microzide, Miglitol, Mistal, Mistletoe, Mitoquinone, Mizibcoc, MLT, Mo Yao, Moduretic, Moexipril, Monopril, Motherwort, Mykrox, Myrrh, N-acetyl Glucosamine, N-acetyl-5-methoxytryptamine, Nadolol, Nadolol and Bendroflumethiazide, Neptazane, Nettle, Nettle Tops, Nicardipine, Nicardipine Injection, Nifediac CC, Nifedipine, Nifedipine ER, Ninjin, Nisoldipine, Nopal, Normodyne, Normodyne Injection, North American Ginseng, Norvasc, NovoLog Mix, Novolin, Novolin 70/30, Ocupress, Ogon, Old woman's broom, Oleum olivae, Olive Oil, Olmesartan, Olmesartan and Hydrochlorothiazide, Opopanax, Opuntia species, Orange Milkweed, Orange Swallow-wort, Oretic, Oriental Ginseng, Orinase, Panax Ginseng, Panax quinquefolius, Panax schinseng, Pearl Barley, Penbutolol, Peri-Colace, Perindopril, Pindolol, Pioglitazone, Pioglitazone and Metformin, Plantago species, Plantain Seed, Plendil, Pleurisy root, Prandin, Precose, Prickly Pear Cactus, Prinivil, Prinzide, Procardia, Procardia XL, Propranolol, Propranolol Injection, Propranolol Oral Solution, Psyllium Seed, Pueraria, Pueraria lobata, Pueraria montana, Pueraria thunbergiana, Puffball, Purging Buckthorn, Purple Medick, Purshiana Bark, Pushkarmoola, Q 10, Quinapril, Ramipril, Ramsthorn, Red Berry, Red Ginseng, Ren Shen, Repaglinide, Rhamnus cathartica, Rhamnus frangula, Rhamnus purshiana, Riomet, Roman Nettle, Rosiglitazone, Rosiglitazone and Metformin, Russian Root, Rustic Treacle, Sacred Bark, Sagrada Bark, Salix, Salix alba, Salix fragilis, Salix purpurea, Scabwort, Scotch Barley, Scute, Scutellaria baicalensis, Sectral, Senexon, Seng, Senna, Senna Laxatives, Senna Oral Syrup, Senna Suppositories, Senna-Gen, Senokot, Senokot Suppositories, Senokot Syrup, Senokot XTRA, Senokot-S, Shigoka, Siberian Ginseng, Silkweed, Snake Plant, Sotalol, Spironolactone, Spironolactone and Hydrochlorothiazide, Stevia, Stevia eupatorium, Stevia rebaudiana, Stickwort, Stinging Nettle, Stinking Rose, Sular, Swallow-wort, Sweet Herb, Sweet Oil, Sweetleaf, Taiga, Taraxacum officinale, Taztia XT, Telmisartan, Tenoretic, Tenormin, Tenormin Injection, Teveten, Thalitone, Thorny Pepperbush, Throw-wort, Tiamate, Tiazac, Timolol Ophthalmic, Timolol Oral, Timoptic, Timoptic-XE, Tolazamide, Tolbutamide, Tolinase, Toprol XL, Torsemide Injection, Torsemide Oral, Touch-Me-Not, Trandate, Trandate Injection, Trandolapril, Triamterene, Triamterene and Hydrochlorothiazide, Trigonella, Trigonella foenum-graecum, Trivalent Chromium, Tuber Root, Turmeric, Turnera diffusa, Ubidecarenone, Ubiquinone, Univasc, Urtica species, Vaccinium myrtillus, Valsartan, Vascor, Vasotec, Velosulin, Velvet Dock, Verapamil, Verapamil Extended-release, Verapamil Injection, Verelan, Verelan PM, Viscum, Viscum album, Visken, Vitamin Q, Vogelmistel, Wacholder, Waythorn, White Root, White Willow, Whitethorn, Whortleberry, Wild Endive, Wild Pepper, Wild Root, Wild Sunflower, Wineberry, Wogon, Wood Spider, Xalcom, Yege, Yellow Starwort, Yerba Dulce, Yinhsing, Zaroxolyn, Zebeta, Zestoretic, Zestril, Zingiber officinale.

Using of Oleae folium

Scientific Name: Olive Leaf

Other Names: Oleae europaea, Oleae folium, Olivier

Who is this for?

One of the most active chemicals found in the leaves of olive trees is known as oleuropein. In animal studies, oleuropein not only prevented the development of high blood pressure but also reduced existing high blood pressure. Although the possible reasons for these effects are not known, it is thought that oleuropein may relax blood vessels, and it may also prevent deposits of plaque that lead to arteriosclerosis or "hardening of the arteries". A few small human studies of olive leaf for controlling high blood pressure have been inconclusive and more studies are needed to confirm or deny these effects.

In other studies, olive leaf extract appeared to lower blood sugar levels in laboratory animals with diabetes. It is believed that olive leaf has a dual effect — it may cause more glucose to be utilized by the body and it may also stimulate the release of insulin. Few results are available from human studies, however. More research into the possible blood sugar-lowering effects of olive leaf is needed before it can be recommended for this use.

In recently reported laboratory studies, extracts of olive leaf have shown anti-infective properties. Extracts are concentrated liquid preparations usually made by soaking chopped or mashed plant parts in a liquid such as alcohol, and then straining out the solid parts. In separate studies, contact with olive leaf extract killed specific types of bacteria and slowed the growth of some skin fungi. Another laboratory study found that an extract of olive leaf interfered with some of the infective properties of HIV, the virus that causes AIDS. Much more study in animals and humans is needed to confirm or disprove the potential anti-infective effects of olive leaf extract.

When should I be careful taking it?

Very little information is available on how olive leaf might affect a developing fetus or an infant. Therefore, its use is not recommended during pregnancy or breast-feeding.

Individuals with diabetes should avoid using large amounts of olive leaf because it can lower blood sugar levels, potentially resulting in hypoglycemia (blood sugar that is too low). Symptoms of low blood sugar include shakiness, sweating, confusion, distorted speech, and loss of muscle control. If not corrected, low blood sugar can lead to unconsciousness and even death.

What side effects should I watch for?

Olive leaf may lower blood pressure by several methods, which may include the widening of blood vessels. Hypotension or blood pressure that is too low may result. Hypotension may not have any definite symptoms, but it may produce blurred vision, confusion, dizziness, or fainting.

What interactions should I watch for?

Due to its possible ability to lower blood pressure, olive leaf is believed to increase the effects of drugs that also lower blood pressure. Some blood pressure-lowering drugs are:

  • ACE inhibitors such as captopril, enalapril, lisinopril, and Monopril
  • Beta blockers such as atenolol, metoprolol, and propranolol
  • Calcium channel blockers such as nifedipine, Norvasc, and verapamil
  • Diuretics such as Dyazide, furosemide, and hydrochlorothiazide

Due to a possible decrease in blood sugar levels, taking olive leaf may increase the effects of insulin and oral drugs for diabetes, such as:

  • Actos
  • Amaryl
  • Avandia
  • glipizide (Glucotrol XL)
  • glyburide (Glynase)
  • Glyset
  • metformin (Glucophage)
  • Prandin
  • Precose

Because olive leaf may decrease blood sugar levels, taking it with other blood sugar-lowering herbal products may result in hypoglycemia — blood sugar that is too low. Herbals that may reduce blood sugar include:

  • Eleuthero
  • Fenugreek
  • Ginger (in high amounts)
  • Kudzu
  • Panax ginseng

Some interactions between herbal products and medications can be more severe than others. The best way for you to avoid harmful interactions is to tell your doctor and/or pharmacist what medications you are currently taking, including any over-the-counter products, vitamins, and herbals.

Should I take it?

Trees that produce olives are thought to have originated in the areas around the Mediterranean Sea. Now growing wild and cultivated in orchards throughout Mediterranean countries, they are also found in warm parts of Africa, Asia, Australia, and the Americas. Generally, cultivated olive trees are kept relatively small so that the ripe fruits can be harvested easily. They have clusters of white or yellow flowers and small narrow leaves that stay green all year. Traditionally the symbol of peace, olive branches were woven into garlands and worn by ancient Greek and Roman leaders. They were also awarded to athletes at the original Olympic games. Today, they are represented on Olympic medals and on many flags including the flag of the United Nations.

For medicinal use, olive leaves may be gathered at any time of the year. Typically, they are dried and used to make a tea or processed into extracts. At various times since the residents of a Mediterranean island named Crete are known to have been using olive leaf as medicine about 5,000 years ago, it has been used to treat a number of chronic and infective illnesses.

Dosage and Administration

Olive leaf is most often sold as capsules or liquid extracts. Extracts are concentrated liquid preparations usually made by soaking chopped or mashed plant parts in a liquid such as alcohol, and then straining out the solid parts. A typical dose is 400 mg four times a day, but dosing recommendations vary considerably. If you use an olive leaf product, follow the directions on the package that you buy.

Olive leaf tea may be made by soaking about 2 teaspoons of dried olive leaf in 5 or 6 ounces of boiling water for 30 minutes. After the solid parts are strained out, olive leaf tea may be taken up to four times a day.

Summary

The major current uses of olive leaf are to lower high blood pressure and high blood sugar, although neither of these effects has been proven through well-controlled studies.

Risks

Pregnant and breast-feeding women are advised to avoid taking olive leaf because not enough is known about its possible effects.

Side Effects

Taking olive leaf may result in hypoglycemia or hypotension.

Interactions

Olive leaf may enhance the effects of drugs that lower blood pressure. It may also increase blood-sugar lowering effects of drugs or herbals.

Last Revised: March 1, 2004

References

Anon: Olive leaf. In: DerMarderosian A, Beutler JA, eds. Facts and Comparisons: The Review of Natural Products. St. Louis, MO, Facts and Comparisons. July 1999.

Briante R, Patumi M, Terenziani S, Bismuto E, Febbraio F, Nucci R. Olea europaea L. leaf extract and derivatives: antioxidant properties. Journal of Agriculture and Food Chemistry. 2002;50(17):4934-4940.

Gonzalez M, Zarzuelo A, Gamez MJ, Utrilla MP, Jimenez J, Osuna I. Hypoglycemic activity of olive leaf. Planta Medica. 1992;58(6):513-515.

Jellin JM, Gregory P, Batz F, Hitchens K, et al, eds. Pharmacist's Letter/Prescriber's Letter. Natural Medicines Comprehensive Database, 3rd Edition. Stockton CA: Therapeutic Research Facility, 2000.

Khayyal MT, el-Ghazaly MA, Abdallah DM, Nassar NN, Okpanyi SN, Kreuter MH. Blood pressure lowering effect of an olive leaf extract (Olea europaea) in L-NAME induced hypertension in rats. Arzneimittelforschung. 2002;52(11):797-802.

Lee-Huang S, Zhang L, Huang PL, Chang YT, Huang PL. Anti-HIV activity of olive leaf extract (OLE) and modulation of host cell gene expression by HIV-1 infection and OLE treatment. Biochemistry and Biophysics Research Communications. 2003;307(4):1029-1037.

Markin D, Duek L, Berdicevsky I. In vitro antimicrobial activity of olive leaves. Mycoses. 2003;46(3-4):132-136.

Onderoglu S, Sozer S, Erbil KM, Ortac R, Lermioglu F. The evaluation of long-term effects of cinnamon bark and olive leaf on toxicity induced by streptozotocin administration to rats. Journal of Pharmacy and Pharmacology. 1999;51(11):1305-1312.

Peirce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: Stonesong Press; 1999.

Somova LI, Shode FO, Ramnanan P, Nadar A. Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies africana leaves. Journal of Ethnopharmacology. 2003;84(2-3):299-305.

Zarzuelo A, Duarte J, Jimenez J, Gonzalez M, Utrilla MP. Vasodilator effect of olive leaf. Planta Medica. 1991;57(5):417-419.


(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

© 2006-2019 LetsDrug.com Contact