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How to use Reglan Injection

Brand Name(s): Reglan Injection

Generic Name Metoclopramide Hydrochloride Injection

What is metoclopramide injection?

METOCLOPRAMIDE (Reglan®) has a number of uses. Metoclopramide helps to control and relieve symptoms of gastroesophageal reflux disease such as heartburn. It is also used to help people with poor motility of the stomach and intestinal tract. Metoclopramide helps to relieve nausea and vomiting associated with the treatment of cancer, surgery, or certain intestinal procedures. Generic metoclopramide injections are available.

What should my health care professional know before I receive metoclopramide?

They need to know if you have any of these conditions:

  • asthma
  • breast cancer
  • depression
  • G6PD deficiency
  • high blood pressure
  • kidney disease
  • methemoglobin reductase deficiency
  • Parkinson's disease or a movement disorder
  • pheochromocytoma
  • seizures (convulsions)
  • stomach obstruction, bleeding, or perforation
  • an unusual or allergic reaction to metoclopramide, procainamide, sulfites, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Metoclopramide is for injection into a muscle or for infusion into a vein. It is usually given by a health-care professional in a hospital or clinic setting.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

This does not apply. If you are being given metoclopramide for the prevention of nausea and vomiting, you will receive it before chemotherapy or before the end of surgery. If you are having metoclopramide injections for diabetic gastroparesis, you will be put on a tablet or syrup once your condition is stable.

What drug(s) may interact with metoclopramide?

  • alcohol
  • bromocriptine
  • cyclosporine
  • digoxin
  • medicines for diabetes, including insulin
  • medicines that treat diarrhea
  • medicines for mental depression
  • medicines for other mental problems or psychotic disturbances
  • medicines for Parkinson's disease, like levodopa
  • medicines for sleep or for pain

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from receiving metoclopramide?

Serious or limiting side effects are uncommon, but may include:

  • breast enlargement in men or women, or production of breast-milk in women who are not breast-feeding
  • change in the way you walk (shuffling feet)
  • difficulty moving, speaking or swallowing
  • drooling, lip smacking, or rapid movements of the tongue
  • involuntary or uncontrollable movements of the eyes, head, arms and legs
  • irregular heartbeat or palpitations
  • muscle twitches and spasms
  • skin rash
  • unusual tiredness or weakness

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • depression
  • diarrhea
  • difficulty sleeping
  • dizziness
  • drowsiness
  • headache
  • menstrual changes
  • restlessness or nervousness

What should I watch for while taking metoclopramide?

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how metoclopramide affects you. Alcohol can increase drowsiness or dizziness; avoid alcoholic drinks.

If you are going to have surgery, tell your prescriber or health care professional that you are having metoclopramide.

Where can I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 °C (59 and 86 °F). Store dilutions under normal light for up to 24 hours. Throw away unused portions.


(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

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