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Using of Talwin

Brand Name(s): Talwin

Generic Name Pentazocine Injection

What is pentazocine injection?

PENTAZOCINE (Talwin®) relieves moderate to severe pain. Pentazocine is sometimes used to help control pain during labor. Generic pentazocine injection is not available.

What should my health care professional know before I take pentazocine?

They need to know if you have any of these conditions:

  • If you frequently drink alcohol-containing beverages
  • constipation
  • head injury
  • heart disease
  • intestinal disease, such as inflammatory bowel disease or ulcerative colitis
  • liver disease
  • lung disease, such as asthma or COPD
  • kidney disease
  • seizures
  • an unusual or allergic reaction to pentazocine, naloxone, codeine, morphine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I take this medicine?

Pentazocine injection will be given as an injection into a muscle or through your vein by a trained health care provider.

What if I miss a dose?

This does not apply.

What drug(s) may interact with pentazocine?

  • medicines called MAO inhibitors- examples: phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®)
  • medicines called SSRIs - examples: fluoxetine (Prozac®), paroxetine (Paxil®), sertraline (Zoloft®), and others

Because pentazocine can cause drowsiness, other medicines that also cause drowsiness may increase this effect of pentazocine. Some medicines that cause drowsiness are:

  • alcohol and alcohol-containing medicines
  • barbiturates such as phenobarbital
  • certain antidepressants or tranquilizers
  • muscle relaxants
  • certain antihistamines used in cold medicines

Ask your prescriber or health care professional about other medicines that may increase the effect of pentazocine.

Tell your prescriber or health care professional about all other medicines that you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also, tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from taking pentazocine?

Side effects that you should report to your prescriber or health care professional as soon as possible:

Rare or uncommon:

  • difficulty passing urine
  • slow or fast heartbeat
  • seizures
  • severe rash
  • unusual weakness

More common:

  • confusion
  • feeling disoriented
  • hallucinations (seeing or hearing things that are not really there)
  • lightheadedness or fainting spells
  • nervousness or restlessness

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • clumsiness, unsteadiness
  • constipation
  • decrease or difficulty passing urine
  • dizziness, drowsiness
  • dry mouth
  • flushing
  • headache
  • itching
  • lightheadedness
  • nausea/vomiting
  • sweating

What should I watch for while taking pentazocine?

Tell your prescriber or health care professional if your pain does not go away, if it gets worse, or if you have new or different type of pain.

You may get drowsy or dizzy when you first start taking pentazocine. Do not drive, use machinery, or do anything that needs mental alertness until you know how pentazocine affects you.

Be careful taking other medicines that may also make you tired. This effect may be worse when taking these medicines with pentazocine. Alcohol can increase possible drowsiness, dizziness, confusion, and affect your breathing. Avoid alcohol while taking pentazocine.

If you are going to have surgery, tell your prescriber or health care professional that you are taking pentazocine.

Where can I keep my medicine?

This does not apply.


(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

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