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What we now about Talwin NX

Brand Name(s): Talwin NX

Generic Name Pentazocine Tablets

What are pentazocine tablets?

PENTAZOCINE (Talwin® Nx) relieves moderate to severe pain. Pentazocine tablets also contain naloxone, which is included to deter the misuse of this medicine. Naloxone does not affect how pentazocine tablets work. Do not share this medicine with anyone else. Federal law prohibits the transfer of pentazocine to any person other than the patient for whom it was prescribed. Generic pentazocine tablets are available.

What should my health care professional know before I take pentazocine?

They need to know if you have any of these conditions:

  • If you frequently drink alcohol-containing beverages
  • constipation
  • head injury
  • heart disease
  • intestinal disease, such as inflammatory bowel disease or ulcerative colitis
  • liver disease
  • lung disease, such as asthma or COPD
  • kidney disease
  • seizures
  • an unusual or allergic reaction to pentazocine, naloxone, codeine, morphine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I take this medicine?

Take pentazocine tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water. If pentazocine upsets your stomach, you can take it with food or milk.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

Do not share this medicine with any one.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What drug(s) may interact with pentazocine?

  • medicines called MAO inhibitors- examples: phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®)
  • medicines called SSRIs - examples: fluoxetine (Prozac®), paroxetine (Paxil®), sertraline (Zoloft®), and others

Because pentazocine can cause drowsiness, other medicines that also cause drowsiness may increase this effect of pentazocine. Some medicines that cause drowsiness are:

  • alcohol and alcohol-containing medicines
  • barbiturates such as phenobarbital
  • certain antidepressants or tranquilizers
  • muscle relaxants
  • certain antihistamines used in cold medicines

Ask your prescriber or health care professional about other medicines that may increase the effect of pentazocine.

Tell your prescriber or health care professional about all other medicines that you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also, tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from taking pentazocine?

Side effects that you should report to your prescriber or health care professional as soon as possible:

Rare or uncommon:

  • difficulty passing urine
  • slow or fast heartbeat
  • seizures
  • severe rash
  • unusual weakness

More common:

  • confusion
  • feeling disoriented
  • hallucinations (seeing or hearing things that are not really there)
  • lightheadedness or fainting spells
  • nervousness or restlessness

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • clumsiness, unsteadiness
  • constipation
  • decrease or difficulty passing urine
  • dizziness, drowsiness
  • dry mouth
  • flushing
  • headache
  • itching
  • lightheadedness
  • nausea/vomiting
  • sweating

What should I watch for while taking pentazocine?

Tell your prescriber or health care professional if your pain does not go away, if it gets worse, or if you have new or different type of pain.

Use exactly as directed by your prescriber or health care professional. If you are taking pentazocine on a regular basis, do not suddenly stop taking it. Your body becomes used to the pentazocine, and when you suddenly stop taking it, you may develop a severe reaction. This DOES NOT mean you are "addicted" to pentazocine. Addiction is a behavior related to getting and using a drug for a non-medical reason. If you have pain, you have a medical reason to take pain medicine such as pentazocine to control your pain.

You may get drowsy or dizzy when you first start taking pentazocine. Do not drive, use machinery, or do anything that needs mental alertness until you know how pentazocine affects you.

Be careful taking other medicines that may also make you tired. This effect may be worse when taking these medicines with pentazocine. Alcohol can increase possible drowsiness, dizziness, confusion, and affect your breathing. Avoid alcohol while taking pentazocine.

If you are going to have surgery, tell your prescriber or health care professional that you are taking pentazocine.

Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open. Do not share or give this medicine to anyone else. Avoid accidental swallowing of pentazocine by someone (especially children) other than the person for whom it was prescribed as this may result in severe effects and possibly death.

Store at room temperature between 15 and 30 °C (59 and 86 °F). Protect from light. Throw away any unused medicine after the expiration date.


(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

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