Known interactions

No interactions found.

Information about Tarka

Brand Name(s): Tarka

Generic Name Verapamil and Trandolapril

What are trandolapril; verapamil sustained-release tablets?

TRANDOLAPRIL-VERAPAMIL (Tarka®) is a combination of two drugs used to lower blood pressure. They lower, but do not cure high blood pressure. Generic trandolapril; verapamil tablets are not yet available.

What should my health care professional know before I take trandolapril; verapamil?

They need to know if you have any of these conditions:

  • autoimmune disease (such as lupus), or suppressed immune function
  • bone marrow disease
  • collagen-vascular disease (such as scleroderma)
  • constipation problems (bowel impaction)
  • difficulty swallowing (or narrowing of the esophagus)
  • heart or blood vessel disease
  • heart rhythm disturbances such as sick sinus syndrome, ventricular arrhythmias, Wolff-Parkinson-White syndrome, or Lown-Ganong-Levine syndrome
  • if you are on a special diet, such as a low-salt diet
  • liver or kidney disease
  • neuromuscular disease such as muscular dystrophy
  • previous swelling of the tongue, face, or lips with difficulty breathing, difficulty swallowing, hoarseness, or tightening of the throat (angioedema)
  • slow or irregular heartbeat
  • stomach problems (obstruction)
  • an unusual or allergic reaction to trandolapril, verapamil, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I take this medicine?

Take trandolapril; verapamil tablets by mouth after a meal. Follow the directions on the prescription label. Swallow the tablets whole with a drink of water, do not break, crush or chew. Do not drink grapefruit juice or alcohol with this medicine. Take trandolapril; verapamil regularly. Do not take your medicine more often than directed. Do not stop taking except on your prescriber's advice.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

Elderly patients over 65 years old may have a stronger reaction to this medicine and need smaller doses.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What drug(s) may interact with Trandolapril; Verapamil?

Do not take Trandolapril; Verapamil with any of the following:

  • alfuzosin
  • astemizole
  • cisapride
  • disopyramide
  • dofetilide
  • grapefruit juice
  • pimozide
  • salt subsitutes which contain potassium
  • terfenadine

Trandolapril; Verapamil may also interact with the following medications:

  • alcohol
  • alosetron
  • aspirin
  • azathioprine
  • antiinflammatory drugs (NSAIDs, such as ibuprofen)
  • barbiturates such as phenobarbital
  • bosentan
  • caffeine
  • certain antibiotics (clarithromycin, erythromycin, telithromycin, trimethoprim, troleandomycin)
  • certain medicines used to treat cancer
  • certain medicines to treat migraine (ergotamine, dihydroergotamine, methysergide)
  • cevimeline
  • cilostazol
  • cimetidine
  • clonidine
  • cyclosporine
  • drospirenone; ethinyl estradiol
  • fentanyl
  • galantamine
  • hymenoptera venom
  • heparin
  • herbal or dietary supplements such as ginger, gingko biloba, ginseng, hawthorn, ma huang (ephedra), melatonin, St. John's wort, went yeast
  • lithium
  • local anesthetics or general anesthetics
  • medicines for anxiety or difficulty sleeping (examples: alprazolam, buspirone, midazolam, triazolam)
  • medicines for anxiety, depression or mental problems (imipramine, fluoxetine, fluvoxamine, nefazodone, ziprasidone)
  • medicines for diabetes
  • medicines for fungal infections (examples: fluconazole, itraconazole, ketoconazole, voriconazole)
  • medicines for heart-rhythm problems (amiodarone, digoxin, flecainide, procainamide, quinidine)
  • medicines for high cholesterol (atorvastatin, cerivastatin, colesevelam, lovastatin, simvastatin)
  • medicines for high blood pressure or heart problems
  • medicines for HIV infection or AIDS
  • medicines for prostate problems
  • medicines for seizures (carbamazepine, clonazepam, ethosuximide, oxcarbazepine, phenobarbital, phenytoin, primidone, zonisamide)
  • methadone
  • methylprednisolone
  • potassium salts (examples: potassium chloride, potassium gluconate)
  • rifabutin
  • rifampin
  • rifapentine
  • sildenafil
  • sirolimus
  • sulfinpyrazone
  • tacrolimus
  • theophylline or aminophylline
  • water pills (diuretics, especially amiloride, triamterene or spironolactone)
  • yohimbine
  • zafirlukast
  • zileuton

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from taking trandolapril; verapamill?

Side effects that you should report to your prescriber or health care professional as soon as possible:

  • decreased amount of urine passed
  • difficulty breathing, or swallowing
  • dizziness, lightheadedness, confusion, or fainting spells
  • persistent dry cough
  • persistent muscle pain
  • sore throat with fever
  • skin rash, itching
  • swelling of your legs or ankles
  • swelling of your face, lips, or tongue
  • tingling, burning or numbness in the fingers and toes
  • uneven or fast heartbeat, chest pain, palpitations

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • change in taste sensation
  • diarrhea or constipation
  • drowsiness
  • flushed or reddened skin
  • headache
  • increased sensitivity to sunlight
  • nausea
  • overgrowth of the gums
  • sexual dysfunction
  • weakness or tiredness

What should I watch for while taking trandolapril; verapamil?

Check your blood pressure and pulse rate regularly; this is important while you are taking trandolapril-verapamil. Ask your prescriber or health care professional what your blood pressure and pulse rate should be and when you should contact him or her.

You may feel dizzy or lightheaded. Do not drive, use machinery, or do anything that needs mental alertness until you know how trandolapril-verapamil affects you. To reduce the risk of dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Avoid alcoholic drinks; they can make you more dizzy, increase flushing and rapid heartbeats.

Do not suddenly stop taking trandolapril-verapamil. Ask your prescriber or health care professional how you can gradually reduce the dose.

If you are going to have surgery, tell your prescriber or health care professional that you are taking trandolapril-verapamil.

Check with your prescriber or health care professional if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of body fluid can make it dangerous to take trandolapril-verapamil.

Avoid salt substitutes or other foods or substances high in potassium salts.

Do not treat yourself for coughs, colds, or pain while you are taking trandolapril-verapamil without asking your prescriber for advice.

This medicine infrequently can cause dental problems for some patients. Clean and floss your teeth carefully and regularly. Check with your dentist if your gums get swollen or inflamed and have the dentist clean your teeth regularly.

Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open.

Store at room temperature between 15 and 25 °C (59 and 77 °F). Protect from moisture and light. Keep container tightly closed. Throw away any unused medicine after the expiration date.

(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

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