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Known interactions

Acular, Acular LS, Advil, Advil Cold & Sinus, Advil Flu & Body Ache, Advil Liqui-Gels, Advil Migraine, AK-Tracin, Aleve, Ampicillin, Ampicillin Oral Suspension, Ampicillin Sodium Injection, Anaprox, Anaprox DS, Ancef, Anectine, Ansaid, Arduan, Arthrotec, Atracurium, Baciguent, Bacitracin Eye Ointment, Bacitracin Topical, Bactocill, Bactocill Injection, Bicillin, Bumetanide, Bumetanide Injection, Bumex, Bumex Injection, Cataflam, Cefazolin Sodium Injection, Cefizox, Cefobid, Cefoperazone Sodium Injection, Cefotan, Cefotaxime Sodium Injection, Cefotetan Disodium Injection, Cefoxitin Sodium Injection, Ceftazidime Injection, Ceftin, Ceftin Suspension, Ceftizoxime Sodium Injection, Ceftriaxone Sodium Injection, Cefuroxime, Cefuroxime Sodium Injection, Cefuroxime Suspension, Cephalothin Sodium Injection, Cephradine, Cephradine Suspension, Ceptaz, Children's Advil, Children's Advil chewable, Children's Motrin, Children's Motrin chewable, Claforan, Clinoril, Combunox, Creatine, Creatine Citrate, Creatine Monohydrate, Creatine Phosphate, D-Amp, Daypro, Demadex Injection, Demadex Oral, Diclofenac, Diclofenac and Misoprostol, Diclofenac Ophthalmic, Diclofenac Potassium, Diclofenac Topical, Diclofenac XR, Doxacurium, Dristan Sinus, EC-Naprosyn, Edecrin, Enflurane, Ethacrynic Acid, Ethrane, Etodolac, Etodolac ER, Feldene, Fenoprofen, Flurbiprofen Ophthalmic Drops, Flurbiprofen Oral, Fortaz, Furosemide, Furosemide Injection, Furosemide Oral Solution, Genpril, Haltran, Hydrocodone and Ibuprofen, Ibuprofen, Ibuprofen and Pseudoephedrine Suspension, Ibuprofen and Pseuodoephedrine, Ibuprofen Chewable Tablets, Ibuprofen Oral Drops, Ibuprofen Suspension, Ibuprofen; Oxycodone tablets, Indocin, Indocin IV, Indocin SR, Indocin Suppositories, Indocin Suspension, Indomethacin, Indomethacin Injection, Indomethacin SR, Indomethacin Suppositories, Indomethacin Suspension, Infants' Advil, Infants' Motrin, Junior Strength Advil, Junior Strength Motrin, Keflin, Kefurox, Kefzol, Ketoprofen, Ketorolac Injection, Ketorolac Ophthalmic Drops, Ketorolac Oral, Lansoprazole and Naproxen, Lasix, Lasix Injection, Lasix Oral Solution, Lodine, Lodine XL, Meclofenamate, Meclomen, Mefenamic Acid, Mefoxin, Menadol, Methoxyflurane, Mezlin, Mezlocillin Sodium Injection, Midol Maximum Strength Cramp Formula, Mivacron, Mivacuronium, Motrin, Motrin Children's Cold Suspension, Motrin IB, Motrin Jr Strength, Motrin Migrain Pain, Motrin Sinus Headache, Nabumetone, Nafcillin, Nafcillin Sodium Injection, Nalfon, Nallpen, Naprelan, Naprosyn, Naprosyn Suspension, Naproxen, Naproxen Oral Suspension, Neomycin and Polymyxin Irrigant, Neosporin G.U. Irrigant, Norcuron, Nuprin, Nuromax, Ocu-Tracin, Ocufen, Omnipen, Omnipen-N, Orudis, Oruvail, Oxacillin, Oxacillin Oral Solution, Oxacillin Sodium Injection, Oxaprozin, Pancuronium, Pavulon, PediaCare Fever, PediaCare Fever Suspension, Pediatric Advil Drops, Penicillin G Potassium, Penthrane, Pfizerpen, Pipecuronium, Piperacillin Sodium and Tazobactam Sodium Injection, Piperacillin Sodium Injection, Pipracil, Piroxicam, Polycillin, Polymyxin B Eye Solution, Polymyxin B Injection, Polytrim Ophthalmic, Ponstel, Prevacid NapraPAC, Principen, Principen Oral Suspension, Quelicin, Relafen, Reprexain, Rocephin, Rocuronium, Rufen, Solaraze, Succinylcholine, Sulindac, Tazicef, Tazidime, Ticarcillin Disodium and Clavulanate Potassium Injection, Timentin, Tolectin, Tolectin DS, Tolmetin, Toradol, Toradol Injection, Torsemide Injection, Torsemide Oral, Totacillin, Totacillin-N, Tracrium, Trimethoprim and Polymyxin Ophthalmic, Tubocurarine injection, Unipen, Unipen Injection, Vancocin, Vancocin Capsules, Vancoled, Vancomycin Capsules, Vancomycin Hydrochloride Injection, Vancomycin Oral Solution, Vanocin Oral Solution, Vecuronium injection, Velosef, Velosef Suspension, Vicoprofen, Voltaren, Voltaren Ophthalmic, Voltaren XR, Wycillin, Zemuron, Zinacef, Zolicef, Zosyn.

Application of TOBI

Brand Name(s): TOBI

Generic Name Tobramycin Inhalation Solution

What is tobramycin solution for inhalation?

TOBRAMYCIN (TOBI®) is an antibiotic. The tobramycin solution is inhaled into the lungs using a special breathing device called a nebulizer. The inhaled solution is used to treat lung infections in patients with cystic fibrosis. Generic tobramycin solution is not available.

What should my health care professional know before I use tobramycin?

They need to know if you have any of these conditions:

  • hearing problems
  • kidney disease
  • an unusual or allergic reaction to tobramycin or other antibiotics, sulfites, foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Tobramycin solution is inhaled into the lungs. It is used with a special breathing device called a nebulizer. Do not swallow the solution by mouth. Follow the directions on the prescription label. Treatment with tobramycin is usually repeated in cycles. Do not use your medicine more often than directed. Finish the full course of medicine prescribed by your prescriber or health care professional even if you think your condition is better.

Make sure you understand how to use your breathing device (nebulizer) before starting treatment. Wash your hands with soap and water before each treatment. When you are ready for a tobramycin treatment, remove one ampule of tobramycin from the foil pouch. Open the nebulizer top. Then, open the tobramycin ampule by holding the bottom tab with one hand and twisting off the top of the ampule with the other. Squeeze all of the contents of the ampule into the nebulizer cap. When you are done, replace the nebulizer top.

During a treatment, sit or stand in a position that will allow you to breathe normally. Place the mouthpiece of the breathing device between your teeth and breathe normally only through your mouth. Continue breathing through the mouthpiece until all the medicine is gone. The entire treatment should take between 10 and 15 minutes. Make sure you clean and disinfect your nebulizer on a regular basis.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is within 6 hours of your next dose, use only that next dose. Do not use double or extra doses.

What drug(s) may interact with tobramycin?

  • mannitol
  • urea
  • water pills such as furosemide (Lasix®)

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from using tobramycin?

Side effects that you should report to your prescriber or health care professional as soon as possible:

  • ringing in the ears, dizziness, or changes in hearing
  • difficulty breathing
  • muscle weakness
  • rash

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • changes in your voice

What should I watch for while taking tobramycin?

Tell your prescriber or health care professional if your symptoms do not improve in a few days.

Tell your prescriber or health care professional if you have ringing in your ears or dizziness after using this medicine.

Where can I keep my medicine?

Keep out of the reach of children.

Store tobramycin pouches (with the ampules) in the refrigerator at 2 and 8 °C (36 and 46 °F). Once you remove them from the refrigerator, tobramycin foil pouches (opened or unopened) can be stored at room temperature for up to 28 days. When stored in the refrigerator, do not use tobramycin after the expiration date on the ampule. When taken out of the refrigerator and stored at room temperature, do not use after 28 days. Do not keep tobramycin ampules near bright light.


(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

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