Known interactions

Absinthe, Actonel with calcium, Adapin, Ajenjo, Alamag, Alamag Suspension, Alenic Alka, Almora, AlternaGEL, AlternaGEL Liquid, Alu-Cap, Alu-Tab, Aludrox, Aluminum and Magnesium Hydroxide, Aluminum and Magnesium Hydroxide Oral Suspension, Aluminum Hydroxide, Aluminum Hydroxide and Magnesium Trisilicate, Aluminum Hydroxide Oral Liquid, Aluminum Hydroxide, Magnesium Carbonate Chewables, Aluminum Hydroxide, Magnesium Carbonate Oral Suspension, Aluminum Hydroxide, Magnesium Hydroxide, and Simethicone, Aluminum Hydroxide, Magnesium Hydroxide, and Simethicone oral suspension, Amitone, Amitriptyline, Amitriptyline Injection, Amoxapine, Amphojel, Amphojel Suspension, Anafranil, Antispasmodic Elixer, Armoise, Artemisia absinthium, Asendin, Atretol, Atropine, Hyoscyamine, Phenobarbital, and Scopolamine Elixir, Atropine, Hyoscyamine, Phenobarbital, and Scopolamine Oral, Aventyl, Aventyl Oral Solution, Bellacane SR, Belladonna Alkaloids, Ergotamine, and Phenobarbital Tablets, Bellaspas, Bellergal-S, Calcium Carbonate Tablets, Caltrate 600, Carbamazepine, Carbamazepine ER, Carbamazepine Suspension, Carbatrol, Cimetidine, Cimetidine Injection, Cimetidine Liquid, Clomipramine, Clozapine, Clozapine Orally-Disentegrating Tablets, Clozaril, Coumadin, Coumadin Injection, Desipramine, Di-Gel, Dialume, Dicarbosil, Donnatal, Donnatal Elixir, Doxepin, Doxepin Oral Solution, Doxepin Topical, E.E.S, Elavil, Elavil Injection, Endep, Ephedra, Ephedra sinica, Epitol, Epitonin, Equetro, Equilet, ERYC, Ertapenem, EryTab, Erythrocin, Erythromycin ER, Erythromycin Tablets, Capsules, and Extended-Release, Etrafon, Evening Primrose, Fazoclo, Felbamate, Felbamate Oral Suspension, Felbatol, Felbatol Oral Suspension, Fever Plant, Fluoxetine and Olanzapine, Fluoxetine capsules (Sarafem), Fluoxetine Oral Solution, Fluoxetine tablets or capsules, Folergot-DF, fluoxetine delayed-release capsules, Gaviscon, Gaviscon Chewable, Gaviscon Chewable Tablets, Ginkgo, Ginkgo Biloba, Green Ginger, Herbal Ecstasy, Hyosophen Elixer, Imipenem and Cilastatin Sodium Injection, Imipramine, Imipramine HCl, Imipramine Pamoate, Invanz, Iosopan, Jantoven, Japanese Silver Apricot, Kew Tree, Lamictal, Lamotrigine, Luminal Sodium, Ma Huang, Maalox, Maalox Suspension, Madderwort, Mag-Ox, Magaldrate, Magnalox, Magnalox Suspension, Magnesium Gluconate, Magnesium Hydroxide, Magnesium Hydroxide Chewable Tablets, Magnesium Oxide, Magnesium Sulfate Injection, Magnox Suspension, Magonate, Magtrate, Mahuang, Maidenhair Tree, Mallamint, Maox, Meropenem Injection, Merrem IV, Milk of Magnesia, Milk of Magnesia-Concentrated, Mintox Suspension, Muzei, Mylanta, Mylanta Oral Suspension, Mylanta tablets, Mysoline, Mysoline Suspension, Norpramin, Nortriptyline, Nortriptyline Oral Solution, OEP, Oenothera species, Pamelor, PCE, Perphenazine and Amitriptyline, Phenerbel-S, Phenobarbital, Phenobarbital Elixir, Phenobarbital Injection, Phillips Milk of Magnesia, Phillips' Chewable, Popptillo, Primaxin, Primidone, Primidone Oral Suspension, Protriptyline, Prozac, Prozac Oral Solution, Prozac Weekly, Riopan, Risedronate with calcium carbonate, Risperdal, Risperdal Consta, Risperdal Oral Solution, Risperidone, Risperidone Injection, Risperidone Oral Solution, Rulox, Sarafem, Sinequan, Sinequan Oral Solution, Solfoton, Spastrin, Sun Drop, Surmontil, Symbyax, Tagamet, Tagamet HB, Tagamet Injection, Tagamet Liquid, Tegretol, Tegretol Suspension, Tegretol XR, Titralac, Tofranil, Tofranil PM, Topamax, Topiramate, Triavil, Trimipramine, Tums, Uro-Mag, Vanatrip, Vanatrip Injection, Vivactil, Warfarin, Warfarin injection, Wermut, Wormwood, Yinhsing, Zonalon Cream.

Application of Valproic Acid Injection

Brand Name(s): Depacon, Valproate Sodium

Generic Name Valproic Acid Injection

What is valproate sodium injection?

VALPROATE SODIUM (Depacon®) can help with seizure (convulsion) control in certain types of epilepsy. Valproate sodium helps to control absence seizures, generalized tonic-clonic seizures, and complex partial seizures. Generic valproate sodium injection is available.

What should my health care professional know before I take valproate sodium?

They need to know if you have any of these conditions:

  • blood disease
  • brain damage or disease
  • kidney disease
  • liver disease
  • low blood proteins
  • urea cycle disorder (UCD)
  • an unusual or allergic reaction to divalproex sodium, valproate sodium, valproic acid, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I take this medicine?

Valproate Sodium is slowly infused into a vein. It is given by a health-care professional in a hospital or clinic setting.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

This does not apply.

What drug(s) may interact with valproate sodium?

  • agents that dissolve blood clots
  • alcohol
  • antiinflammatory drugs (NSAIDs, such as ibuprofen)
  • aspirin
  • barbiturate medicines for inducing sleep or treating seizures (convulsions)
  • blood thinners
  • diazepam
  • isoniazid
  • medicines for mental depression
  • medicines for mental problems and psychotic disturbances
  • other seizure (convulsion) or epilepsy medicines
  • zidovudine, AZT

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from taking valproate sodium?

Side effects that you should report to your prescriber or health care professional as soon as possible:

  • agitation, restlessness, irritability, or other changes in mood
  • blurred or double vision or uncontrollable eye movements
  • changes in the frequency or severity of seizures
  • double vision, or involuntary eye movements
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • skin rash or itching
  • stomach pain or cramps
  • trembling of hands or arms
  • unusual bleeding or bruising or pinpoint red spots on the skin
  • unusual swelling of the arms or legs
  • unusual tiredness or weakness
  • yellowing of skin or eyes

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • breast enlargement, unusual production of breast milk
  • changes in menstrual periods
  • clumsiness or unsteadiness
  • diarrhea or constipation
  • difficulty speaking
  • dizziness or drowsiness
  • headache
  • increased sensitivity to sun or ultraviolet light
  • irregular menstrual cycle
  • irritation at the site of injection
  • loss of bladder control
  • loss of hair or unusual growth of hair
  • loss or increase in appetite
  • nausea or vomiting
  • skin rash, itching
  • weight gain or loss

What should I watch for while taking valproate sodium?

If you are taking valproate sodium to treat epilepsy (seizures), do not stop taking valproic acid suddenly. This increases the risk of seizures. Wear a Medic Alert bracelet or necklace. Carry an identification card with information about your condition, medications, and prescriber or health care professional.

You may get drowsy, dizzy, or have blurred vision. Do not do anything that needs mental alertness until you know how valproate sodium affects you. To reduce dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Alcohol can increase drowsiness and dizziness. Avoid alcoholic drinks.

Valproate sodium can cause blood problems. This can mean slow healing and a risk of infection. Problems can arise if you need dental work, and in the day to day care of your teeth. Try to avoid damage to your teeth and gums when you brush or floss your teeth.

If you are going to have surgery, tell your prescriber or health care professional that you are taking valproate sodium.

Where can I keep my medicine?

Store at room temperature between 15 and 30 °C (59 and 86 °F). Opened vials should be discarded after use. Throw away any unused medicine after the expiration date.

(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

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