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Quick guide to Vfend Injection
Brand Name(s): Vfend Injection
Generic Name Voriconazole Injection
What is voriconazole injection?
VORICONAZOLE (VFEND®) is an antifungal type of antibiotic. It treats serious fungal infections found throughout the body. These infections include aspergillosis, which is often found in the lung, and other types of mold or yeast infections. Generic voriconazole injections are not yet available.
What should my health care professional know before I receive voriconazole?
They need to know if you have any of these conditions:
- eye disease
- kidney disease
- liver disease
- other chronic illness
- an unusual or allergic reaction to voriconazole, or other azole medicines, other foods, dyes or preservatives
- pregnant or trying to get pregnant
- breast-feeding
How should I use this medicine?
Voriconazole is for infusion into a vein. You will most likely receive this drug in a hospital or clinic setting. However, your health care professional may order that this medication be given to you at home. Finish the full course prescribed by your prescriber or health care professional even if you feel better. Do not stop using except on your prescriber's advice.
Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.
What if I miss a dose?
Usually this will not apply as you will receive this drug in the hospital or clinic. If you are receiving this medicine at home and it is almost time for your next dose, use only that dose. Do not take double or extra doses.
What drug(s) may interact with voriconazole?
Voriconazole has the potential to interact with many other drugs. Some of the possible interactions are listed:
- alosetron
- amiodarone
- amphotericin B
- astemizole
- barbiturates, like phenobarbital
- bromocriptine
- calcium channel blockers like amlodipine, diltiazem or verapamil
- cevimeline
- cilostazol
- cisapride
- cocaine
- cyclosporine
- dapsone
- dextromethorphan
- disopyramide
- dofetilide
- donepezil
- ergotamine or dihydroergotamine
- ethanol
- galantamine
- grapefruit juice
- halofantrine
- isoniazid, INH
- levomethadyl
- medicines for depression, anxiety, psychosis or other mood problems
- medicines for diabetes
- medicines for HIV infection
- medicines for insomnia (sleep problems)
- medicines for seizures like carbamazepine, clonazepam, ethosuximide, phenobarbial, phenytoin, valproic acid and others
- medicines for treating high cholesterol, like atorvastatin, fluvastatin, lovastatin or simvastatin
- methadone
- mifepristone, RU-486
- modafinil
- nystatin
- omeprazole
- prescription pain medications or muscle relaxants
- quinidine
- quinine
- rifampin
- sibutramine
- sildenafil
- sirolimus
- some medicines for treating cancers
- St. John's wort
- tacrolimus
- tamoxifen
- terfenadine
- warfarin
Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
What side effects may I notice from taking voriconazole?
Side effects that you should report to your prescriber or health care professional as soon as possible:
- dark yellow or brown urine
- difficulty breathing
- severe problems with your eyesight or eye pain
- redness, blistering, peeling or loosening of the skin, including inside the mouth
- skin rash, itching
- stomach pain
- unusual bruising or bleeding
- yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
- blurred vision
- flashing lights or bright spots in your field of vision
- headache
- hotness or flushing of the skin
- loss of appetite
- nausea, vomiting
What do I need to watch for when I receive voriconazole?
Tell your prescriber or health care professional if your symptoms do not improve in a few weeks. Some fungal infections need many weeks or months of treatment to cure. Keep using your medicine regularly for as long as your prescriber or health care professional tells you to.
You may need to visit your prescriber or health care professional for regular blood, kidney and liver function tests.
Alcohol can increase possible damage to your liver. Do not drink alcoholic beverages while you take this medicine.
Do not drink grapefruit juice while receiving voriconazole therapy. Grapefruit juice may lead to higher levels of voriconazole in your blood.
Voriconazole should not be taken during pregnancy. If you are pregnant or think you may be pregnant, tell you prescriber or health care professional immediately. Women who may become pregnant should use effective birth control while receiving voriconazole treatment.
Where can I keep my medicine?
Keep out of the reach of children in a container that small children cannot open.
Store voriconazole according to your health care provider's instructions; do not freeze. Do not use if the solution is discolored or there is particulate matter present. Throw away any unused medicine after the expiration date.
(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)
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