русский

Known interactions

2-Amino-2-Deoxyglucose, Absinthe, Acanthopanax senticosus, Acarbose, Acetazolamide, Acetazolamide Injection, Acetazolamide Sustained-Release, Acetohexamide, Achillea, Achillea millefolium, Ackerkraut, Actoplus Met, Actos, Agathosma betulina, Agoral Liquid, Agrimonia, Agrimonia eupatoria, Agrimony, Airelle, Ajenjo, AK-Zol, Alant, Aldactazide, Aldactone, Alder Buckthorn, Alder Dogwood, Alfalfa, Alhova, Allium, Allium sativum, Aloe barbadensis, Aloe species, Aloe vera, Amaryl, American Ginseng, Amiloride and Hydrochlorothiazide, Amorphophallus konjac, Anchi, Apidra, Aquatensen, Armoise, Arrow Wood, Artemisia absinthium, Asian Ginseng, Atenolol and Chlorthalidone, Avandamet, Avandia, Azucacaa, Baikal Scullcap, Baikal Skullcap Root, Bal, Barley, Barley Grass, Barosma betulina, Basket Willow, Bdellium, Benicar HCT, Bilberry, Bird's Foot, Bitter Bark, Black Dogwood, Black ginger, Black Psyllium, Black-Draught, Blond Psyllium, Bloodwort, Blowball, Bol, Bramhi, Bucco, Buchu, Buku, Bumetanide, Bumetanide Injection, Bumex, Bumex Injection, Burn Plant, California Buckthorn, Canadian Ginseng, Canker Wort, Canton ginger, Cape Aloe, Capim Doce, Cascara, Cassia acutifolia, Cassia angustifolia, Cassia senna, Centella asiatica, Chinese Ginseng, Chinese Knotweed, Chitosamine, Chittem Bark, Chlorothiazide, Chlorothiazide Injection, Chlorothiazide Suspension, Chlorpropamide, Chlorthalidone, Chroma-Pak injection, Chromic Chloride injection, Chromium, Chromium 3, Chromium Acetate, Chromium Chloride, Chromium chloride injection, Chromium injection, Chromium Picolinate, Church Steeples, Ci Wu Jia, Climbing Knotweed, Co Q 10, Cochin ginger, Cocklebur, Coenzyme Q-10, Commiphora molmol, Commiphora myrrha, Common Buckthorn, Common ginger, Corzide, Crack Willow, Curcuma, Curcuma species, Daidzein, Damiana, Dandelion, Demadex Injection, Demadex Oral, Devil's Bush, Devil's Claw, Devil's Leaf, Devil's Tongue, Diabeta, Diabinese, Diamox, Diamox Injection, Diamox Sequels, Diosma, Diurigen, Diuril, Diuril Injection, Diuril Suspension, Docusate and Senna, Dog Wood, Dyazide, Dyeberry, Dymelor, Dyrenium, Edecrin, Elecampane, Elephant-foot Yam, Eleuthero, Eleutherococcus senticosus, Elf Dock, Elfwort, Enduron, Erva Doce, Esidrix, Ethacrynic Acid, Eucalyptus, European Blueberry, European Buckthorn, Evening Primrose, Exlax, Exlax Chocolated, Ezide, Fenugreek, Feuille de Luzerna, Fever Plant, Five Fingers, Flea Seed, Flowery Knotweed, Fo-Ti, Fortamet, Frangula Bark, Funffing, Furosemide, Furosemide Injection, Furosemide Oral Solution, Garden ginger, Garlic, Ge Gen, Gingembre, Ginger, Ginkgo, Ginkgo Biloba, Ginseng, American, Ginseng, Panax, GlaucTabs, Glimepiride, Glipizide, Glipizide and Metformin, Glipizide Extended-Release, Glossy Buckthorn, Glucomannan, Glucophage, Glucophage XR, Glucosamine, Glucosamine Hydrochloride, Glucosamine Sulfate, Glucotrol, Glucotrol XL, Glucovance, Glyburide, Glyburide and Metformin, Glynase, Glyset, Gotu Kola, Grapple Plant, Greek Clover, Greek Hay, Green Arrow, Green Ginger, Guggal Resin, Guigai, Gum Myrrh, Gurmar, Gymnema sylvestre, Harpagophytum procumbens, Hartshorn, He Shou Wu, Heerabol, Herba de la pastora, Herbe de Saint-Guillaume, Highwaythorn, Hordeum vulgare, Horse-elder, Horseheal, Hu Lu Ba, Huang Qin, Huckleberry, Humalog, Humalog Mix 75/25, Humulin, Humulin 50/50, Humulin 70/30, Hwanggum, Hydrochlorothiazide, Hydrocotyle asiatica, HydroDIURIL, Hygroton, Iletin II, Iletin II Mixed, Imber, Indapamide, Indian Pennywort, Indian Saffron, Insulin - Mixed, Insulin glulisine, Insulin injection, Insulin Lispro, Inula helenium, Irish Daisy, Isphagula, Jamaican ginger, Japanese Arrowroot, Japanese Ginseng, Japanese Silver Apricot, Kaa Jhee, Kew Tree, Konjac, Konjac Mannan, Konnyaku, Korean Ginseng, Kudzu, Lasix, Lasix Injection, Lasix Oral Solution, Leotodon taraxacum, Lion's Tooth, Lisinopril and Hydrochlorothiazide, Liverwort, Lopressor HCT, Lozol, Lucerne, Madderwort, Mai Ya, Maidenhair Tree, Marsh Penny, Maxiumum Relief Exlax, Maxzide, MEL, Medicago, Medicago sativa, Melatonin, Merasingi, Metaglip, Metformin, Metformin Extended-Release, Metformin Oral Solution, Methazolamide, Methi, Methyclothiazide, Metolazone, Metolazone extended-release tablets, Metoprolol and Hydrochlorothiazide, Mexican damiana, Micronase, Microzide, Miglitol, Milfoil, Mitoquinone, Mizibcoc, MLT, Mo Yao, Moduretic, Mykrox, Myrrh, N-acetyl Glucosamine, N-acetyl-5-methoxytryptamine, Nadolol and Bendroflumethiazide, Neptazane, Nettle, Nettle Tops, Ninjin, Nopal, North American Ginseng, Nosebleed Plant, NovoLog Mix, Novolin, Novolin 70/30, OEP, Oenothera species, Ogon, Old woman's broom, Oleae europaea, Oleae folium, Oleum olivae, Olive Leaf, Olive Oil, Olivier, Olmesartan and Hydrochlorothiazide, Opopanax, Opuntia species, Oretic, Oriental Ginseng, Orinase, Panax Ginseng, Panax quinquefolius, Panax schinseng, Pearl Barley, Peri-Colace, Pioglitazone, Pioglitazone and Metformin, Plantago species, Plantain Seed, Polygonum multiflorum, Prandin, Precose, Prickly Pear Cactus, Prinzide, Psyllium Seed, Pueraria, Pueraria lobata, Pueraria montana, Pueraria thunbergiana, Puffball, Purging Buckthorn, Purple Medick, Purshiana Bark, Pushkarmoola, Q 10, Ramsthorn, Red Berry, Red Ginseng, Ren Shen, Repaglinide, Rhamnus cathartica, Rhamnus frangula, Rhamnus purshiana, Riomet, Roman Nettle, Rosiglitazone, Rosiglitazone and Metformin, Russian Root, Rustic Treacle, Sacred Bark, Sagrada Bark, Salix, Salix alba, Salix fragilis, Salix purpurea, Scabwort, Scotch Barley, Scute, Scutellaria baicalensis, Senexon, Seng, Senna, Senna Laxatives, Senna Oral Syrup, Senna Suppositories, Senna-Gen, Senokot, Senokot Suppositories, Senokot Syrup, Senokot XTRA, Senokot-S, Shigoka, Siberian Ginseng, Snake Plant, Spironolactone, Spironolactone and Hydrochlorothiazide, Staunch Weed, Stevia, Stevia eupatorium, Stevia rebaudiana, Stickwort, Stinging Nettle, Stinking Rose, Sun Drop, Sweet Herb, Sweet Oil, Sweetleaf, Taiga, Taraxacum officinale, Tenoretic, Thalitone, Thorny Pepperbush, Thousand-Leaf, Tolazamide, Tolbutamide, Tolinase, Torsemide Injection, Torsemide Oral, Touch-Me-Not, Triamterene, Triamterene and Hydrochlorothiazide, Trigonella, Trigonella foenum-graecum, Trivalent Chromium, Turmeric, Turnera diffusa, Ubidecarenone, Ubiquinone, Urtica species, Vaccinium myrtillus, Velosulin, Velvet Dock, Vitamin Q, Waythorn, Wermut, White Willow, Whortleberry, Wild Endive, Wild Pepper, Wild Sunflower, Wineberry, Wogon, Wood Spider, Wormwood, Wound Wort, Yarrow, Yarroway, Yege, Yellow Starwort, Yerba Dulce, Yinhsing, Zaroxolyn, Zestoretic, Zingiber officinale.

Using of Wacholder

Scientific Name: Juniper

Other Names: Enebro, Genevrier, Ginepro, Juniperus communis, Kuli, Wacholder

Who is this for?

Traditionally, juniper has been taken by mouth to treat conditions of the gastrointestinal tract, such as gas, indigestion, and poor appetite. It is believed that juniper may relieve gastrointestinal complaints that are related to low stomach acid levels by promoting the secretion of stomach acid. Additionally, juniper has some antiseptic action that may help to eliminate gastrointestinal bacteria and parasites. Recent laboratory studies show that juniper preparations may stop or slow down the spread of some organisms that contaminate foods and it may have some effects against certain kinds of cancer, as well. Juniper is also thought to increase slightly the loss of water from the body. This mild diuretic action may be useful for relieving excess water accumulation. In animal studies, oral juniper preparations lowered blood sugar levels, possibly by increasing insulin production and/or by increasing sugar utilization. None of these effects have been well studied in humans.

Juniper contains volatile oils, also called essential oils, which possess a characteristic turpentine-like smell and give the plant a bitter taste. Juniper oil should not be taken by mouth, but it may be applied to the skin to relieve minor injuries such as burns, cold sores, insect bites, razor burn, scrapes, and sunburn. Juniper oil may also be rubbed on aching muscles or joints. Some evidence from case reports suggests that juniper oil may have anti-inflammatory effects, but no clinical studies support its use for inflammatory conditions.

Juniper tar, or cade oil, is a thick topical preparation made from the wood of some juniper species. It has been used for psoriasis and other inflammatory skin conditions, but it has also been associated with potentially cancer-causing changes in the DNA of human skin. Because of this very serious potential risk, juniper tar should be used only under the supervision of a healthcare professional.

Allowing juniper oil to evaporate, boiling the berries, or adding the oil to boiling water creates a vapor that may be inhaled to lessen bronchial congestion. Its possible anti-inflammatory effect may also help relieve inflammation in the lungs. Due the same anti-inflammatory potential, juniper may be included in bath oils used in treating arthritis and other conditions.

When should I be careful taking it?

In studies of female animals, juniper has caused the muscles of the uterus to tighten. In addition, it appears to interfere with fertility. Therefore, juniper should not be taken, applied, or inhaled by women who are pregnant or trying to become pregnant.

Juniper may cause irritation to the stomach in individuals who have gastroesophageal reflux disease (GERD), stomach ulcers, and other gastrointestinal (GI) disorders that result from excess acid secretion. Therefore, juniper should be avoided by individuals with GI conditions. Juniper can also cause irritation to the kidneys, so it should be avoided in individuals with kidney disorders.

Precautions

Very little information is available on how juniper might affect an infant or a small child. Therefore, its use is not recommended while breast-feeding or during childhood.

Allergic reactions such as rashes and breathing difficulties have been reported after using juniper products, handling juniper plants, or inhaling juniper pollen. Limited scientific literature suggests that individuals of Oriental heritage may be more likely to have juniper allergies than Europeans or Americans.

Because juniper has been shown to reduce blood levels of sugar in both diabetic and non-diabetic laboratory animals, individuals who have diabetes should monitor their blood sugar levels more closely while taking juniper.

A tar derived from juniper oil occasionally is used to treat inflammatory skin conditions such as psoriasis. It should be used only with medial supervision, though, due to a possible association with skin cancers.

What side effects should I watch for?

Kidney damage or seizures have been reported in some individuals who took more than 10,000 mg (10 grams) of juniper per day or who took high doses of juniper for longer than 4 weeks.

Less Severe Side Effects

Purplish or red-tinted urine may result if large amounts of juniper are taken by mouth.

Using juniper on the skin may result in:

  • Irritation
  • Redness
  • Swelling

Rarely, breathing juniper vapors or steam may cause stomach cramps.

What interactions should I watch for?

Prescription Drugs

The possible mild diuretic effect of juniper could increase the effectiveness of diuretics, also called "water pills". If you take a diuretic drug, such as furosemide, or hydrochlorothiazide, talk to your doctor or pharmacist before using juniper.

Diuretics may also promote the loss of potassium from the body. Since taking juniper may lead to potassium loss, as well, the levels of potassium in the blood may become too low if juniper is taken at the same time as a diuretic. Low blood potassium is called hypokalemia. Symptoms of hypokalemia can include:

  • Abdominal cramps
  • Constipation
  • Low blood pressure
  • Muscle weakness
  • Nausea
  • Vomiting
  • Hallucinations
  • Respiratory failure
  • Cardiac arrest

Individuals with diabetes should avoid taking large amounts of juniper because it can lower blood sugar levels, potentially resulting in hypoglycemia (blood sugar that is too low). Symptoms of low blood sugar may include shakiness, sweating, confusion, distorted speech, and loss of muscle control. If not corrected, low blood sugar can lead to unconsciousness and even death. Taking juniper may interfere with insulin and oral drugs for diabetes, such as:

  • Actos
  • Amaryl
  • Avandia
  • glipizide (Glucotrol XL)
  • glyburide (Glynase)
  • Glyset
  • metformin (Glucophage)
  • Prandin
  • Precose

Herbal Products

Because juniper may decrease blood sugar levels, taking it with other blood sugar-lowering herbal products may result in hypoglycemia — blood sugar that is too low. Herbals that may reduce blood sugar include:

  • Eleuthero
  • Fenugreek
  • Ginger (in high amounts)
  • Kudzu
  • Panax ginseng

The potential loss of water from juniper's diuretic effect may decrease blood levels of potassium, as well. When juniper is taken with other potassium-depleting herbals such as horsetail or true licorice, the chances of potassium deficiency increase. Low potassium levels may result in symptoms such as drowsiness, heart rhythm changes, nausea, and vision disturbances.

Some interactions between herbal products and medications can be more severe than others. The best way for you to avoid harmful interactions is to tell your doctor and/or pharmacist what medications you are currently taking, including any over-the-counter products, vitamins, and herbals.

Should I take it?

The juniper family includes more than 60 species of generally slow-growing evergreens. Some species are ground covers; others get as tall as 30 feet. They grow well in most cool climates of the Northern Hemisphere. Since junipers are fragrant and low-maintenance, they are used frequently in gardens and landscaping. Female plants bear pale blue flowers in the late spring. Green berries or tiny pine-cone-shaped fruits develop, but they do not mature into a dark blue or purple color until the second year.

Mature juniper berries are collected in the fall to be used fresh, dried, or crushed to extract their oil. With a spicy, slightly bitter taste, juniper berries are used to flavor foods and beverages — for example, they give the alcoholic drink gin its distinctive taste. They are also used as a spice or a food preservative in some parts of the world. Juniper oil provides a fragrance for bath salts, candles, cosmetics, perfumes, and soaps. For medicine, juniper berries are usually taken by mouth in their dried form. The oil is applied to the skin surface. Either the berries or the oil can be added to boiling water and the steam inhaled.

Dosage and Administration

Note: Juniper should never be used for longer than 4 weeks at a time due to the possibility of kidney damage. Doses should be limited to a maximum of 10,000 mg (10 grams) of dried juniper berries by mouth or 100 mg of topical juniper oil per day. Juniper oil should not be taken by mouth.

Juniper tea may be made by soaking one teaspoonful of dried juniper berries in about 6 ounces of boiling water for 10 to 15 minutes and then straining out the solid parts before drinking. Juniper tea may be taken one to four times a day. A usual dose of dried juniper berries is 1,000 mg to 2,000 mg (one gram to 2 grams) up to three times a day. Juniper is also available in other oral dose forms, with different recommended doses. If you decide to use juniper, follow the directions on the package of the product you purchase. Do not take more than the recommended amounts.

For application to the skin, juniper oil should be used sparingly. A small amount may be applied to minor skin irritations once or twice a day for a few days, at the most. Juniper tar (cade oil) should not be used topically unless a healthcare professional oversees its use.

Juniper berries or oil may be added to warm bath water to help relieve the pain of arthritis or muscle aches. The berries may also be boiled in water and the resulting steam may be inhaled to treat bronchitis and other upper respiratory complaints. Care should be taken to see that the steam is not hot enough to cause burns on the face or in the respiratory tract.

Summary

Juniper berries or tea may be taken orally to treat stomach conditions. They may also promote water loss from the body. On the skin, juniper oil may be used for minor skin injuries. Vapors from the oil or steam from the boiling berries may be inhaled to relieve lung congestion.

Risks

Pregnant women and women attempting to become pregnant should not use juniper because it may cause uterine spasms and it may decrease fertility. Due to irritating effects on the stomach and kidneys, juniper should also be avoided by individuals who have stomach or kidney diseases.

Not enough is known about juniper's effects to recommend it for children or breast-feeding women. Individuals with diabetes should watch their blood sugar levels closely if they take juniper due to its possible reducing effect on blood sugar.

Side Effects

Oral doses of juniper over 10,000 mg (10 grams) per day or for longer than 4 weeks have caused kidney damage and seizures. Topical juniper oil may result in irritation and swelling at the sites where it is applied. Juniper tar (cade oil) has been linked to skin damage that eventually may lead to skin cancer.

Interactions

Orally, juniper may interfere with diuretics and drugs or herbals used to treat diabetes.

Last Revised June 3, 2004

References

Anon. Final report on the safety assessment of Juniperus communis extract, Juniperus oxycedrus extract, Juniperus oxycedrus tar, Juniperus phoenicea extract, and Juniperus virginiana extract. International Journal of Toxicology. 2001;20(Suppl 2):41-56.

Anon: Juniper. In: DerMarderosian A, Beutler JA, eds. Facts and Comparisons: The Review of Natural Products. St. Louis, MO, Facts and Comparisons. February 1997.

Argento A, Tiraferri E, Marzaloni M. Oral anticoagulants and medicinal plants. An emerging interaction. [article in Italian] Annales Italian Medica Internationale. 2000;15(2):139-143.

Ashley K. Juniper Berry. Ethnobotanical Leaflet. Southern Illinois University, Carbondale. May 7, 2000. Available at: http://www.siu.edu/~ebl/leaflets/juiper.htm. Accessed June 19, 2003.

Bayazit V. Cytotoxic effects of some animal and vegetable extracts and some chemicals on liver and colon carcinoma and myosarcoma. Saudi Medical Journal. 2004;25(2):156-163.

Butani L, Afshinnik A, Johnson J, et al. Amelioration of tacrolimus-induced nephrotoxicity in rats using juniper oil. Transplantation. 2003;76(2):306-311.

Cosentino S, Barra A, Pisano B, Cabizza M, Pirisi FM, Palmas F. Composition and antimicrobial properties of Sardinian Juniperus essential oils against foodborne pathogens and spoilage microorganisms. Journal of Food Protection. 2003;66(7):1288-1291.

Filipowicz N, Kaminski M, Kurlenda J, Asztemborska M, Ochocka JR. Antibacterial and antifungal activity of juniper berry oil and its selected components. Phytotherapy Research. 2003;17(3):227-231.

Gardner DR, Panter KE, James LF, Stegelmeier BL. Abortifacient effects of lodgepole pine (Pinus contorta) and common juniper (Juniperus communis) on cattle. Veterinary and Human Toxicology. 1998;40(5):260-263.

Grieve M. Juniper berries. In: A Modern Herbal. New York: Dover Publishers, 1971. Available at: http://www.botanical.com/botanical/mgmh/mgmh.html Posted 1995. Accessed June 6, 2003.

Haughton C. Juniperis communis. Revised September 23, 2002. Available at: http://www.purplesage.org.uk/profiles/juniper.htm. Accessed June 6, 2003.

Jellin JM, Gregory P, Batz F, Hitchens K, et al, eds. Pharmacist's Letter/Prescriber's Letter. Natural Medicines Comprehensive Database, 3rd Edition. Stockton CA: Therapeutic Research Facility, 2000.

Moreno L, Bello R, Beltran B, Calatayud S, Primo-Yufera E, Esplugues J. Pharmacological screening of different Juniperus oxycedrus L. extracts. Pharmacology and Toxicology. 1998;82(2):108-112.

Sanchez de Medina F, Gamez MJ, Jimenez I, Jimenez J, Osuna JI, Zarzuelo A. Hypoglycemic activity of juniper "berries". Planta Medica. 1994;60(3):197-200.

Schoket B, Horkay I, Kosa A, Paldeak L, Hewer A, Grover PL, Phillips DH. Formation of DNA adducts in the skin of psoriasis patients, in human skin in organ culture, and in mouse skin and lung following topical application of coal-tar and juniper tar. Journal of Investigational Dermatology. 1990;94(2):241-246.

Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetologia. 1990;33(8):462-464.

Topcu G, Erenler R, Cakmak O, Johansson CB, Celik C, Chai HB, Pezzuto JM. Diterpenes from the berries of Juniperus excelsa. Phytochemistry. 1999;50(7):1195-1199.

Yarnell E. Botanical medicines for the urinary tract. World Journal of Urology. 2002;20(5):285-293.


(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

© 2006-2019 LetsDrug.com Contact