Known interactions

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Application of Wogon

Scientific Name: Baikal Scullcap

Other Names: Baikal Skullcap Root, Huang Qin, Hwanggum, Ogon, Scute, Scutellaria baicalensis, Wogon

Who is this for?

Note: Baikal or Chinese scullcap (Scutellaria baicalensis) is different from a related plant called American scullcap (Scutellaria laterifolia).

Baikal scullcap was among seven ingredients in a combination oral herbal product known as PC-SPES that was used to treat prostate cancer. The U.S. Food and Drug Administration (FDA) initiated a nationwide recall of all PC-SPES in 2002 because the capsules were found to contain varying amounts of prescription drugs.

Other combination formulas containing Baikal scullcap are used in Asian medicine to improve impaired brain function and to treat headaches.

Baicalin, one chemical found in Baikal scullcap, is known to be anti-inflammatory. It is also antifungal, particularly for Candida, and it also seems to have antiviral properties; including possible effectiveness against HIV, the virus that causes AIDS. In animal studies, Baikal scullcap also has shown some effectiveness against diabetes and high blood pressure, but none of these effects has been studied in humans.

When should I be careful taking it?

PC-SPES should not be used.

Due to unpredictable effects on stomach function, individuals with stomach or spleen disorders should not take Baikal scullcap.

Individuals with diabetes should avoid using Baikal scullcap because it blocks an enzyme that breaks down starches in the intestines. As a result, sugars are absorbed more slowly and blood sugar levels do not fluctuate as much. Potentially hypoglycemia (blood sugar that is too low) could occur. Symptoms of low blood sugar may include shakiness, sweating, confusion, distorted speech, and loss of muscle control. If not corrected, low blood sugar can lead to unconsciousness and even death.


Very little information is available on how Baikal scullcap might affect a developing fetus, an infant, or a small child. Therefore, its use is not recommended during pregnancy, breast-feeding, or early childhood.

What side effects should I watch for?

A few reports of liver damage have been associated with taking Baikal scullcap. The individuals involved, however, were taking products that could have been contaminated with other herbal products or chemicals.

Less Severe Side Effects

Baikal scullcap could cause drowsiness.

What interactions should I watch for?

Prescription Drugs

In animal studies, chemicals in Baikal scullcap have been shown to block an enzyme that digests starches from food. As a result, blood sugar levels may be lower than expected. If Baikal scullcap is taken at the same time that insulin or oral antidiabetic drugs are used to control diabetes, the effects of the drugs could be increased. Blood sugar levels could become too low, resulting in a condition called hypoglycemia. Signs of hypoglycemia include shakiness, sweating, confusion, distorted speech, and loss of muscle control. If not corrected, low blood sugar can lead to unconsciousness and even death.

When Baikal scullcap is used with prescription drugs that promote sleepiness, the effects of the drug may be exaggerated, resulting in sedation or mental impairment. Prescription drugs that can cause sleepiness include:

  • Anticonvulsants such as carbamazepine, phenytoin and valproic acid
  • Barbiturates such as phenobarbital
  • Benzodiazepines such as alprazolam and diazepam
  • Drugs for insomnia such as zaleplon and zolpidem
  • Tricyclic antidepressants such as amitriptyline, amoxapine, doxepin and nortriptyline

Non-prescription Drugs

The sleep-producing effects of over-the-counter products containing diphenhydramine can be enhanced by taking Baikal scullcap at the same time. Diphenhydramine is contained in many over-the-counter sleep aids as well as in some cough and cold products, therefore caution should be used when taking these medications with Baikal scullcap because excessive drowsiness may result.

Herbal Products

Baikal scullcap may cause excessive sedation if taken with other sedating herbs such as:

  • Catnip
  • Hops
  • Kava
  • St. John's Wort
  • Valerian


No interactions between Baikal scullcap and foods have been reported, but drinking alcohol at the same time as using Baikal scullcap by mouth may result in increased drowsiness.

Some interactions between herbal products and medications can be more severe than others. The best way for you to avoid harmful interactions is to tell your doctor and/or pharmacist what medications you are currently taking, including any over-the-counter products, vitamins, and herbals.

Should I take it?

A species related to but different from the scullcap that grows in North America, Baikal scullcap originated in eastern Asia, where it has been used for centuries to treat infections of the gastrointestinal and respiratory tracts. It is named for the Lake Baikal region of Russia, where it grows abundantly. Today, in Eastern medicine it is most often combined with other herbs to treat prostate cancer.

The part of Baikal scullcap that is used in medicine is the root, which is dug in the fall or spring of the year and then dried. Often the dried root is roasted, much like coffee beans are roasted, to improve the flavor. Plants are allowed to grow for 3 to 4 years before the roots are harvested.

Dosage and Administration

Note: PC-SPES, a combination product that contained Baikal scullcap, has been removed from the U.S. market. It is very important not to take any PC-SPES capsules until they are re-formulated. Please discard any PC-SPES capsules that you might have.

Baikal scullcap is often combined with other herbals. Dosing for Baikal scullcap and the combinition products that contain it varies according to the condition being treated and the combination product being used. If you decide to use it, follow the directions on the package that you purchase.


Most frequently combined with other herbals in a product known as PC-SPES, Baikal scullcap is used to treat prostate cancer. PC-SPES has been recalled in the United States, however, due to contamination with prescription drugs. Therefore, do not take PC-SPES.

Baikal scullcap may also be antifungal, antiviral, and anti-inflammatory. It may be beneficial in treating diabetes and high blood pressure, but these uses need much more study before any of them can be recommended.


Individuals who have diabetes, stomach conditions, or spleen disorders should avoid taking Baikal scullcap. Its use is not recommended for small children, or breast-feeding or pregnant women.

Side Effects

Baikal scullcap could cause drowsiness. In addition, some cases of liver damage have been associated with the use of Baikal scullcap. It is believed, however, that contamination with other substances was involved.


Because it promotes sleepiness, Baikal scullcap can increase the sedation associated with certain prescription drugs, non-prescription drugs, other dietary supplements, and alcohol. It should be used carefully, if at all while drugs for anxiety, colds and coughs, epilepsy, or insomnia are being taken. Many other medications may cause drowsiness, so a doctor or pharmacist should be consulted before Baikal scullcap is taken with any prescription, non-prescription, or herbal product.

Baikal scullcap may have a lowering effect on blood sugar, therefore it may increase the effectiveness of medications used for the treatment of diabetes. If you are taking insulin or oral drugs for diabetes, talk to your doctor or pharmacist before using Baikal scullcap.

Baikal scullcap may have a lowering effect on blood sugar, therefore it may increase the effectiveness of medications or herbals used for the treatment of diabetes. If you are taking insulin or oral drugs for diabetes, talk to your doctor or pharmacist before using Baikal scullcap.


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(Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.)

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