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Known interactions between the following drugs: Activella, Synthroid

1 interaction was found for the drugs you selected.

LEVOTHYROXINE in Synthroid may interact with ESTRADIOL in Activella
Estrogens may increase the thyroxine-binding globulin (protein substances in the blood that attach to thyroid hormones) concentrations causing levothyroxine to decrease in the blood. This may lead to an increase in signs and symptoms of hypothyroidism. When starting estrogens while on levothyroxine it may be necessary for your doctor to increase the dose of the levothyroxine. Your doctor may want to closely monitor your blood while starting the estrogens to see if the levothyroxine needs adjusting. Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems.

This interaction is well-documented and is considered moderate in severity.


(Note: Not all drug interactions are known or reported in the literature, and new drug interactions are continually being reported. This information is provided only for your education and for you to discuss with your personal healthcare provider.)

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