Known interactions between the following drugs: Captopril, Magan

Magnesium salicylate blocks the production of chemicals known as prostaglandins. Certain types of prostaglandins cause the muscles inside of blood vessels to relax and also promote the elimination of sodium and water by the kidneys, both of which contribute to a decrease in blood pressure. Although it does not seem to directly prevent vasodilation or alter the blood pressure-lowering ability of captopril, magnesium salicylate may lessen the overall benefit of using captopril because of its effect on the prostaglandins. Based on information from one study involving a small number of people who took captopril and a drug that is similar to magnesium salicylate at the same time, this does not appear to cause any harmful effects. However, this interaction may be more significant in people with heart disease. If magnesium salicylate and captopril are taken together on a regular basis, your doctor may want to check your blood pressure more often and make sure that your heart is functioning properly. If you are experiencing problems, you may consider using a non-aspirin pain reliever as an alternative to magnesium salicylate. Your doctor may also consider switching to a drug that is similar to captopril but that is less likely to cause problems with magnesium salicylate. You may want to ask your healthcare provider about this potential interaction if you think you are having problems.