1 interaction was found for the drugs you selected.
SIMVASTATIN in Zocor
may interact with DILTIAZEM in Cardizem LA
Diltiazem may block the breakdown of simvastatin in the body. If this happens, blood levels of simvastatin could be increased. This could cause a serious or potentially life-threatening side effect that involves the destruction of muscle tissue and could lead to kidney failure. Avoid using these drugs together if possible. However, if it is necessary to take diltiazem and simvastatin at the same time, you should be advised to watch for symptoms like unexplained muscle pain, tenderness, or weakness. If you are experiencing problems, your doctor may consider using an alternative to simvastatin for reducing cholesterol. Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems.
This interaction is well-documented and is considered moderate in severity.