Known interactions between the following drugs: Celexa, Combunox

A possible side effect from ibuprofen (especially with chronic use and the use of high doses) is gastrointestinal bleeding or the development of ulcers. Although the cause of this interaction is not clearly understood, citalopram, when taken with ibuprofen, may increase this risk of gastrointestinal bleeding. If possible, avoid taking citalopram with ibuprofen. If you must take these medications together, your doctor should monitor you closely for gastrointestinal side effects and adjust the dose of these medications if needed. Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems.

Both citalopram and oxycodone have an effect on serotonin, a chemical that is found in the brain. Excess levels of serotonin in the brain may cause serious or potentially life-threatening side effects. Early signs of this problem include increased confusion and restlessness. Other possible symptoms may include weakness, fever, nausea, abdominal cramping, and anxiety. In rare cases, high levels of serotonin in the brain may cause severe complications like seizures, stroke, and even death. If these drugs are used together, your doctor may want to monitor you closely when therapy with citalopram is started or stopped. If you are experiencing problems, it may be necessary to adjust the dose of oxycodone or to stop therapy with either drug. Ask your healthcare provider about these drugs and this potential interaction as soon as possible.