Known interactions between the following drugs: Celexa, Demerol Injection

Both citalopram and meperidine have an effect on serotonin, a chemical that is found in the brain. Excess levels of serotonin in the brain may cause serious or potentially life-threatening side effects. Early signs of this problem include increased confusion and restlessness. Other possible symptoms may include weakness, fever, nausea, abdominal cramping, and anxiety. In rare cases, high levels of serotonin in the brain may cause severe complications like seizures, stroke, and even death. If these drugs are used together, your doctor may want to monitor you closely when therapy with citalopram is started or stopped. If you are experiencing problems, it may be necessary to adjust the dose of meperidine or to stop therapy with either drug. Ask your healthcare provider about these drugs and this potential interaction as soon as possible.