Known interactions between the following drugs: Celexa, Erythrocin

Erythromycin may block the breakdown of citalopram by the liver. If this happens, blood levels of citalopram could be increased and this could increase the risk of side effects including nausea, dizziness, headaches, and sleep disturbances. Other more serious side effects may occur due to citalopram's effect on serotonin, a chemical that is found in the brain. Initially, excess levels of serotonin in the brain may cause increased confusion and restlessness. Other possible symptoms may include weakness, fever, nausea, and anxiety. In rare cases, high levels of serotonin in the brain may cause severe complications like seizures, stroke, and even death. If these drugs are used together, your doctor may want to monitor you closely when therapy with erythromycin is started or stopped, or when the dose of erythromycin is changed. If you are experiencing problems, it may be necessary to adjust the dose of citalopram. You may want to ask your healthcare provider about this potential interaction if you think you are having problems.