1 interaction was found for the drugs you selected.
SIBUTRAMINE HYDROCHLORIDE in Meridia may interact with
DEXTROMETHORPHAN in Cheracol D Cough Liquid
Both sibutramine and dextromethorphan have an effect on serotonin, a chemical that is found in the brain. Excess levels of serotonin in the brain may cause serious or potentially life-threatening side effects. Early signs of this problem include increased confusion and restlessness. Other possible symptoms may include weakness, fever, nausea, and anxiety. In rare cases, high levels of serotonin in the brain may cause severe complications like seizures, stroke, and even death. These drugs should generally not be used at the same time. However, if these drugs must be used together, your doctor may want to monitor you closely for side effects. Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems.
This interaction is well-documented and is considered major in severity.