Known interactions between the following drugs: Children's Kaopectate, Lisinopril

Bismuth subsalicylate blocks the production of chemicals known as prostaglandins. Certain types of prostaglandins cause the muscles inside of blood vessels to relax and also promote the elimination of sodium and water by the kidneys, both of which contribute to a decrease in blood pressure. Although it does not seem to directly prevent vasodilation or alter the blood pressure-lowering ability of lisinopril, bismuth subsalicylate may lessen the overall benefit of using lisinopril because of its effect on the prostaglandins. Based on information from one study involving a small number of people who took drugs that are similar to bismuth subsalicylate and lisinopril at the same time, this does not appear to cause any harmful effects. However, this interaction may be more significant in people with heart disease. If bismuth subsalicylate and lisinopril are taken together on a regular basis, your doctor may want to check your blood pressure more often and make sure that your heart is functioning properly. If you are experiencing problems, it may be necessary to stop therapy with bismuth subsalicylate. Your doctor may also consider switching to a drug that is similar to lisinopril but that is less likely to cause problems with bismuth subsalicylate. You may want to ask your healthcare provider about this potential interaction if you think you are having problems.