1 interaction was found for the drugs you selected.
SIMVASTATIN in Zocor
may interact with CHOLESTYRAMINE in Cholestyramine Powder for Suspension
When these drugs are taken at the same time, cholestyramine may combine with simvastatin in the stomach and prevent it from being absorbed properly into the body. If this happens, then potentially less simvastatin would be available for the body to use. This could make simvastatin less effective. If these drugs are used together, avoid taking simvastatin within 4 hours after a dose of cholestyramine. To make this schedule easier to follow, consider taking cholestyramine before meals and then take simvastatin in the evening before bedtime. Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems.
This interaction is poorly documented and is considered moderate in severity.