Known interactions between the following drugs: Clozaril, Lisinopril

Although the cause of this potential interaction is not clearly understood, the side effects of clozapine may be increased if taken together with lisinopril. These side effects include drowsiness, dry mouth, abdomnial pain, nausea, headache, and constipation. Because only a limited amount of information is available on this potential interaction, more clinical studies will be needed to determine the safety of using these drugs together. If these drugs are taken together, your doctor may want to monitor you more closely for your response to clozapine, especially when therapy with lisinopril is either started or stopped or the dose of lisinopril is adjusted. If you are experiencing problems, it may be necessary to decrease the dose of clozapine. Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems.