Known interactions between the following drugs: Coumadin Injection, Naproxen

Blood clotting normally occurs in response to a cut or other types of injuries to protect the body from excessive bleeding. Platelets, a type of cell found in the blood, are involved in helping the blood to clot when it is needed. Naproxen may interfere with the platelets' ability to work properly. It may also damage the lining of the stomach, particularly when used for a long period of time, and this may increase the risk of developing a bleeding ulcer. Warfarin is generally used to prevent your blood from "coagulating" or forming blood clots. When naproxen and warfarin are used at the same time, your blood may be much less likely to clot and this may increase the risk of excessive bleeding. If it is necessary to use naproxen while you are taking warfarin, your doctor may want to monitor you closely for signs of bleeding. Let your doctor know if your bowel movements appear black or tarry, or if you are having any stomach pain. Blood tests can be used to make sure that you are getting the right amount of warfarin. If you are experiencing problems, it may be necessary to adjust the dose of warfarin. Your doctor may also consider stopping therapy with naproxen. Ask your healthcare provider about these drugs and this potential interaction as soon as possible.