Known interactions between the following drugs: Crestor, Diflucan Oral

Fluconazole may block the breakdown of rosuvastatin by the liver. If this happens, blood levels of rosuvastatin could be increased. This could cause a serious and potentially life threatening side effect that involves the destruction of muscle tissue and could lead to kidney failure. Avoid using these drugs together if possible. However, if it is necessary to take fluconazole and rosuvastatin together, you may be advised to watch for symptoms like unexplained muscle pain, tenderness, or weakness. Your doctor may consider adjusting the dose of rosuvastatin if needed or switching you to another drug to lower your cholesterol. Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems.