Known interactions between the following drugs: Crestor, Neoral

Rosuvastatin is broken down into active and inactive by-products by the liver--a process referred to as "drug metabolism". Cyclosporine may interfere with the liver's ability to metabolize rosuvastatin. As a result, blood levels of rosuvastatin may become elevated. This could cause a serious or potentially life-threatening side effect that involves the destruction of muscle tissue and may lead to kidney failure. Cyclosporine and rosuvastatin should generally not be taken together. However, if it is necessary to use these drugs at the same time, your doctor may adjust your dose of rosuvastatin and advise you to watch for symptoms like unexplained muscle pain, tenderness, or weakness. Ask your healthcare provider about these drugs and this potential interaction as soon as possible.