Known interactions between the following drugs: Demerol Oral, L-tryptophan

1 interaction was found for the drugs you selected.

Tryptophan in L-tryptophan may interact with MEPERIDINE HYDROCHLORIDE in Demerol Oral
Currently, tryptophan is not recommended for use as a dietary supplement. In the body, tryptophan is converted to serotonin, which is a neurotramsmitter (a natural chemical that carries signals between nerve cells) that affects appetite, mood, and sleep. Because meperidine may raise serotonin levels in the body, taking it with tryptophan may increase serotonin to potentially unsafe levels. The risk of developing serotonin syndrome, a rare but potentially dangerous condition, may also increase. Early symptoms of serotonin syndrome may include confusion, fever, hallucinations, nausea, or trembling - mainly in the feet and legs. If it is not controlled, serotonin syndrome may result in coma, seizures, and death. Tryptophan is not recommended for use - especially while meperidine is taken. Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems.

This interaction is poorly documented and is considered minor in severity.

(Note: Not all drug interactions are known or reported in the literature, and new drug interactions are continually being reported. This information is provided only for your education and for you to discuss with your personal healthcare provider.)

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