Known interactions between the following drugs: Dihydroergotamine Nasal Spray, Meridia

Both sibutramine and dihydroergotamine have an effect on serotonin, a chemical that is found in the brain. Excess levels of serotonin in the brain may cause serious or potentially life-threatening side effects. Early signs of this problem include increased confusion and restlessness. Other possible symptoms may include weakness, fever, nausea, and anxiety. In rare cases, high levels of serotonin in the brain may cause severe complications like seizures, stroke, and even death. Sibutramine and dihydroergotamine should generally not be used at the same time. However, if you must use these drugs together, your doctor may want to monitor you closely for side effects. Ask your healthcare provider about these drugs and this potential interaction as soon as possible.