1 interaction was found for the drugs you selected.
SERTRALINE HYDROCHLORIDE in Zoloft
may interact with NAPROXEN in Aleve
A possible side effect from naproxen (especially with chronic use and the use of high doses) is gastrointestinal bleeding or the development of ulcers. Although the cause of this interaction is not clearly understood, sertraline, when taken with naproxen, may increase this risk of gastrointestinal bleeding. If possible, avoid taking sertraline with naproxen. If you must take these medications together, your doctor should monitor you closely for gastrointestinal side effects and adjust the dose of these medications if needed. Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems.
This interaction is poorly documented and is considered moderate in severity.