1 interaction was found for the drugs you selected.
St. John's Wort in Hypericum perforatum
may interact with OMEPRAZOLE in Prilosec OTC
St. John's Wort may speed up the breakdown of omeprazole in the body which could decrease the effectiveness of omeprazole. If possible, avoid taking these products together. If St. John's Wort and omeprazole must be used together, your doctor should monitor your response to omeprazole and increase the dose if needed. Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems.
This interaction is poorly documented and is considered moderate in severity.
(Note: Not all drug interactions are known or reported in the literature, and new drug interactions are continually being reported. This information is provided only for your education and for you to discuss with your personal healthcare provider.)