1 interaction was found for the drugs you selected.
NAPROXEN in Naproxen
may interact with METOPROLOL in Toprol XL
Naproxen can block the blood pressure-lowering effect of metoprolol. Clinical studies have shown that a small increase in blood pressure may occur when these two drugs are taken at the same time. It is generally recommended to avoid using naproxen and metoprolol together, if possible. However, if these drugs must be used at the same time, your doctor may want to closely monitor your blood pressure and adjust the dose of metoprolol if needed. Your doctor may also consider switching to a different drug that is less likely to interact with metoprolol. Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems.
This interaction is well-documented and is considered moderate in severity.