Known interactions between the following drugs: Oxycodone, Paxil CR

1 interaction was found for the drugs you selected.

OXYCODONE in Oxycodone may interact with PAROXETINE HYDROCHLORIDE in Paxil CR
Both paroxetine and oxycodone have an effect on serotonin, a chemical that is found in the brain. Excess levels of serotonin in the brain may cause serious or potentially life-threatening side effects. Early signs of this problem include increased confusion and restlessness. Other possible symptoms may include weakness, fever, nausea, abdominal cramping, and anxiety. In rare cases, high levels of serotonin in the brain may cause severe complications like seizures, stroke, and even death. If these drugs are used together, your doctor may want to monitor you closely when therapy with paroxetine is started or stopped. If you are experiencing problems, it may be necessary to adjust the dose of oxycodone or to stop therapy with either drug. Ask your healthcare provider about these drugs and this potential interaction as soon as possible.

This interaction is poorly documented and is considered moderate in severity.

(Note: Not all drug interactions are known or reported in the literature, and new drug interactions are continually being reported. This information is provided only for your education and for you to discuss with your personal healthcare provider.)

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